Prognostic Value of Circular RNA ciRS-7 in Various Cancers: A PRISMA-Compliant Meta-Analysis

Abstract

Background. Circular RNAs (circRNAs) have been shown to be involved in tumorigenesis. As a member of circRNAs, ciRS-7 is thought to be a negative prognostic indicator in multiple types of cancer. The present study aimed to comprehensively explore the value of ciRS-7 in tumor malignancy. Materials and Methods. A systematic review of PubMed, Web of Science, and the Cochrane library was carried out to examine the related studies. The pooled odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated from the available publications by STATA 12.0. Subgroup analysis, publication bias, sensitivity analysis, and meta-regression were conducted. Results. This meta-analysis included 1,714 patients from 13 cohorts. The results suggested that high ciRS-7 expression was significantly associated with overall survival (OS) (HR = 2.17, 95% CI = 1.50–3.15, P<0.001) in various cancers. Stratified analyses indicated that elevated levels of ciRS-7 appeared to be a powerful prognostic biomarker for patients with non-small-cell lung cancer (NSCLC) (HR: 2.50, 95% CI: 1.07–6.07, P=0.035), colorectal cancer (CRC) (HR: 1.95, 95% CI: 1.34–2.84, P<0.001), and gastric cancer (GC) (HR: 2.32, 95% CI: 1.48–3.64, P<0.001). A similar effect was also observed in subgroup of sample size, analysis method, and cutoff value, except for ethnicity. The increased ciRS-7 expression was associated with a higher tumor stage (OR = 2.30, 95% CI: 1.69–3.13, P<0.001). Conclusions. High expression of ciRS-7 has a significant correlation with the high stage in various cancers, and ciRS-7 is intimately associated with an adverse OS in numerous cancers. Thus, ciRS-7 may act as a potential biomarker for the development of malignancies.

Circular RNA circSMARCA5 is a prognostic biomarker in patients with malignant tumor: a meta-analysis

“…Yuan et al claimed that circRNAs might serve as potential biomarkers for colorectal cancer [ 24 ]. In addition, 2 independent meta-analyses suggested that circRNA CDR1as could act as diagnostic and prognostic biomarkers in various malignant tumors [ 10 , 25 ]. Exploring the value of circRNAs as biomarkers will provide promising guidance for clinical decision.…”

“…Furthermore, circRNAs can be used as diagnostic and prognostic markers for malignant tumors [ 8 , 9 ]. Previous meta-analyses have verified the prognostic values of ciRS-7 [ 10 ] and circHIPK3 [ 11 ] in malignant tumor patients.…”

Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysis

“…Its predictive value in diagnosis and prognosis for malignancy has been gradually explored. Several circRNAs have been certified to be associated with the development and progression of various tumors, such as ciRs-7 [ 34 ]. The predictive role of circRNA in different malignancies, including lung cancer, colorectal cancer, and laryngeal cancer, has also been reported recently [ 35 – 37 ].…”

The Emerging Picture of the Roles of CircRNA-CDR1as in Cancer

“…Many studies have demonstrated that CDR1as is expressed abnormally in many cancer types (Pan et al, 2018;Su et al, 2018;Tanaka et al, 2019;Lin et al, 2020;Tian et al, 2020;Zhou et al, 2020). The expression of CDR1as is upregulated in most tumors, such as colorectal cancer, hepatocellular carcinoma and breast cancer, and it exerts a tumor-promoting effect (Tang et al, 2017;Weng et al, 2017;Xu et al, 2017;Yuan et al, 2019;Zhang Z. et al, 2020;Zhao Y. H. et al, 2020).…”