Prognostic and Diagnostic Significance of circRNA Expression in Esophageal Cancer: A Meta-analysis

Abstract

Background and Aims. Circular RNA (circRNA) demonstrates potential biological application in various solid tumors. We intended to evaluate the diagnostic, prognostic, and clinicopathological value of circRNA for esophageal cancer (EC). Methods. We screened relative studies from Pubmed, Embase, Web of Science, and Cochrane Library. The diagnostic role of circRNAs was testified by pooled sensitivity and specificity. Pooled odds ratio (OR) and pooled hazard ratio (HR) were computed to appraise the clinicopathological and prognostic value, respectively. Results. There were total 15 articles suitable with our included criteria, in which 7 for diagnosis, 8 for prognosis, and 9 for clinicopathological features. The pooled sensitivity and specificity were 0.77 and 0.80, respectively, while the AUC was 0.85. Patients with aberrant expression of circRNAs had a 2.92-fold increased risk of developing EC. The proportion of EC patients with normal circRNA expression only accounted for 29%. Upregulated expression of oncogenic circRNA was correlated with poor clinicopathological features, including lymph node metastasis, tumor size, and T classification, while downregulation of tumor-suppressor circRNA was contributed to worse TNM stage. As for prognosis, upregulated expression of circRNA carried out a diverse survival outcome, with a pooled HR of 2.76 for tumor promoter and that of 0.21 for tumor suppressor. High expression of oncogenic circRNA in both plasma and tumor tissue would lead to a shorter survival duration. Conclusion. circRNAs might be a promising biomarker for diagnosis, prognosis, and clinicopathological features of EC.

Diagnostic and prognostic value ofcircRNAsexpression in head and neck squamous cell carcinoma: A meta‐analysis

“…Four previous meta‐analyses by Wang 80 , Ding 81 , Li 82 , and Tan 83 examined the association between circRNAs and cancer, and confirmed that circRNAs might play an important role in the diagnosis and prognosis of human cancer. The predictive role of circRNAs in different malignancies, including esophageal cancer 84 , lung cancer 85 , and colorectal cancer 86 , has also been confirmed recently. However, there are few articles on HNSCC tumors in these meta‐analyses.…”

Circular_0086414 induces SPARC like 1 (SPARCL1) production to inhibit esophageal cancer cell proliferation, invasion and glycolysis and induce cell apoptosis by sponging miR-1290

“…CircRNA is an endogenous noncoding RNA that plays roles in transcription, methylation modification, and information transport [ 28 ]. Recently, multiple research data have suggested that circRNA is abnormally expressed in EC [ 29 ], providing a crucial reference for treating EC. Based on the lacking data on the function of circ_0086414 in EC development, the study was organized to analyze the role of circ_0086414 in EC development.…”

New Circulating Circular RNAs with Diagnostic and Prognostic Potential in Advanced Colorectal Cancer

“…By Cox regression analysis, left primary tumor location (HR = 0.57, 95% CI: 0.36-0.91, p = 0.019; HR = 0.61, 95% CI: 0.38-0.97, p = 0.036, Table 3) and CEA ≤2 ULN (HR = 0.51, 95% CI: 0.32-0.80, p = 0.003; HR = 0.52, 95% CI: 0.33-0.80, p = 0.004, Table 3) were defined as independent predictors for longer overall survival of our metastatic CRC patients. 2018), miR-106a and miR-181b are sponged by hsa_circ_0007915 and hsa_circ_0001445, respectively [9,17]. If these miRNAs are targets for circRNAs, their levels would be dysregulated.…”

“…Comparing the two miRNAs we found that miR-181b exhibited greater diagnostic power with an AUC value of 0.891 (95% CI: 0.84-0.94, p < 0.0001, Figure 5c), with 88.24% sensitivity, and with 83.33% specificity at Youden Index 0.716 than the miR-106a with an AUC = 0.774 (95% CI: 0.70-0.85, p < 0.0001, Figure 5d), with 84.38% sensitivity and 64.44% specificity at larger Youden Index 0.488. 2018) , miR-106a and miR-181b are sponged by hsa_circ_0007915 and hsa_circ_0001445 , respectively [9,17]. If these miRNAs are targets for circRNAs, their levels would be dysregulated.…”

“…The best biomarkers, however, remain to be found. Following miRNA studies, the clinical relevance of long non-coding RNAs (lncRNAs) has also been posited in multiple cancer types regarding their applicability, not only as a new way to understand the fundamental mechanisms of oncogenesis, but mainly as diagnostic, prognostic and predictive tools [7][8][9].…”