Prognostic Value of Carbonic Anhydrase IX and Ki-67 Expression in Squamous Cell Carcinoma of the Tongue

Kim, Seok Jin; Shin, Hye Jin; Jung, Kwang‐Yoon; Baek, Seung Kuk; Shin, Bong Kyung; Choi, Juwhan; Kim, Byung Soo; Shin, Sang Won; Kim, Yeul Hong; Kim, Jun Suk; Oosterwijk, Egbert

doi:10.1093/jjco/hym121

Cited by 55 publications

(60 citation statements)

References 23 publications

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“…Ki-67 expression did not correlate with overall survival in any other stage, possibly because Ki-67 expression below 33% was generally observed in only stage I OTSCC. Other studies in oral cancer investigating the correlation between Ki-67 expression and overall survival in patients found conflicting results although several studies confirmed that a lower Ki-67 expression exhibited better patient survival (Gonzalez-Moles et al, 1996;Piffko et al, 1996;Stoll et al, 2000;Myoung et al, 2006;Kim et al, 2007). One study by Kim et al (2007) observed a significantly longer patient survival when Ki-67 expression was below 10% in OTSCC patients.…”

Section: Discussionmentioning

confidence: 99%

“…This study was limited by our small population size; however, OTSCC is a sub-site specific cancer with very few published articles. Methodologically, different approaches in Ki-67 immunohistochemical evaluation were used, making comparison difficult due to lack of one standardised assessment method (Pich et al, 2004;Kim et al, 2007). In addition, a limitation of the study is the heterogeneity of treatment modalities among the different stages of OTSCC.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have shown that aneuploid tumours are more aggressive than diploid tumours in head and neck cancers (Hogmo et al, 1994;Rubio Bueno et al, 1998). Proliferative activity, as determined by expression levels of the Ki-67 nuclear antigen, has been linked to prognosis and treatment prediction with varying results in oral cancer, with few studies performed exclusively in OTSCC (Xie et al, 1999;Pich et al, 2004;Lothaire et al, 2006;Kim et al, 2007). The use of immunohistochemistry and DNA cytometry are cost-effective and robust clinical tests.…”

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confidence: 99%

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Ki-67 expression predicts locoregional recurrence in stage I oral tongue carcinoma

et al. 2008

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Oral tongue squamous cell carcinoma (OTSCC) is an aggressive cancer associated with poor prognosis. Methods for determining the aggressiveness of OTSCC from analysis of the primary tumour specimen are thus highly desirable. We investigated whether genomic instability and proliferative activity (by means of Ki-67 activity) could be of clinical use for prediction of locoregional recurrence in 76 pretreatment OTSCC paraffin samples (stage I, n ¼ 22; stage II, n ¼ 33; stage III, n ¼ 8; stage IV, n ¼ 13). Eleven surgical tumour specimens were also analysed for remnants of proliferative activity after preoperative radiotherapy. Ninety-seven percent of cases (n ¼ 72) were characterised as being aneuploid as measured by means of image cytometry. Preoperative radiotherapy (50 -68 Gy) resulted in significant reduction of proliferative activity in all patients for which post-treatment biopsies were available (P-value ¼ 0.001). Proliferative activity was not associated with response to radiation in stage II patients. However, we report a significant correlation between high proliferation rates and locoregional recurrences in stage I OTSCC patients (P-value ¼ 0.028). High-proliferative activity is thus related to an elevated risk of recurrence after surgery alone. We therefore conclude that Ki-67 expression level is a potentially useful clinical marker for predicting recurrence in surgically treated stage I OTSCC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Ki-67 expression predicts locoregional recurrence in stage I oral tongue carcinoma

et al. 2008

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“…Bettendorf et al (14) concluded that Ki-67 staining alone cannot be used to predict prognosis in patients with oral cancer. Kim et al (17) reported that presence of the Ki-67 bio-marker determines the worst prognosis for patients with OSCC. About 93% of our samples did not stain for the bcl-2 marker and only 6.7% expressed bcl-2 weakly.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Clinical, Demographic, Pathological, and Molecular Factors with Survival Rate of Patients with Oral Squamous cell Carcinoma in Yazd city During 1998–2008

Tabatabaei

Tafti

Hossini

et al. 2015

3dj

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Introdouction:Squamous cell carcinoma is the most common oral cancer and the prognosis because of a late diagnosis remains poor despite numerous treatments. Therefore, we conducted a cross-sectional study to investigate the relationships between survival rate(SR) of oral squamous cell carcinoma (OSCC) and clinical,demographic, pathological, and molecular factors in Yazd city during 1998-2008. Materials and methods:Data related to 30 Yazdian patients with OSCC who were referred to Shahid Sadoughi Dental School and Hospital during 1998-2008 were evaluated according to census data. Clinical and histopathological data were gathered via phone calls, and archived specimens were immunohistochemically stained to examine the cell proliferation index (Ki-67), the anti-apoptotic index (bcl2), and a tumor suppressor indicator(p53). The data were analyzed using SPSS statistical software (V.17) via a Kaplan-Meier analysis, and p <0.05 was considered significant. Results:Eighteen cases (60%) were females and 12(40%) were males. The mean 5-year SR was lower in men than women and in patients >50 years of age than <50 years, the mean SR from lowest to highest were record to labial, lingual and intraoral involvement respectively and for smokers and patients with a moderate disease grade(II) and intense p53 staining tended to be lower than other categories; however, the differences were not significant. The overall 5-year SR of patients was 55% in this study, and the mean survival was 6.6 years. Conclusion:The SR was lower in older men and smokers Therefore, a more radical treatment and longer follow-upafter treatment for older male smokers are recommended.

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“…Cyclin B1 is useful in predicting occult cervical lymph-node metastasis in OSCC (Harada et al, 2006). Ki-67 and PCNA are wellestablished cell proliferation markers, and Ki-67 expression increases sharply in early OSCC, but significantly decreases during disease progression (Derka et al, 2006), while that of PCNA was not significantly associated with the survival (Kim et al, 2007;Lim et al, 2005;Myoung et al, 2006). Akt plays a pivotal role in cell survival and proliferation.…”

Section: Cell Cycle Progression and Proliferation Biomarkersmentioning

confidence: 99%

Functional Biomarkers of Oral Cancer

Tsuda¹,

Ohba²

2012

Oral Cancer

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Prognostic Value of Carbonic Anhydrase IX and Ki-67 Expression in Squamous Cell Carcinoma of the Tongue

Abstract: The expression of CA IX and Ki-67 may be useful for predicting prognosis in squamous cell carcinoma of the tongue.

Cited by 55 publications

References 23 publications

Ki-67 expression predicts locoregional recurrence in stage I oral tongue carcinoma

Ki-67 expression predicts locoregional recurrence in stage I oral tongue carcinoma

Evaluation of Clinical, Demographic, Pathological, and Molecular Factors with Survival Rate of Patients with Oral Squamous cell Carcinoma in Yazd city During 1998–2008

Functional Biomarkers of Oral Cancer

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