Prognostic value of admission serum magnesium in acute myocardial infarction complicated by malignant ventricular arrhythmias

Mizuguchi, Yoshifumi; Konishi, Takao; Nagai, Toshiyuki; Sato, Tomoya; Takenaka, Sakae; Tada, Atsushi; Kobayashi, Yuta; Komoriyama, Hirokazu; Kato, Yoshiya; Omote, Kazunori; Sato, Takuma; Kamiya, Kiwamu; Tsujinaga, Shingo; Iwano, Hiroyuki; Kikuchi, Kenjiro; Tanaka, Shinya; Anzai, Toshihisa

doi:10.1016/j.ajem.2021.02.005

Cited by 7 publications

(9 citation statements)

References 28 publications

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“…On the other hand, the level of sodium was not varied significantly between the two groups regarding the level of serum magnesium, and although the mean level of hemoglobin was lower among AMI patients with low serum magnesium levels, there was no significant difference. Therefore, we did not find any association between the level of serum magnesium and hemoglobin and sodium level, and this was in contrast to the previous study [ 9 ].…”

Section: Discussioncontrasting

confidence: 99%

“…A study conducted on 465 consecutive AMI patients complicated with malignant ventricular arrhythmia categorized patients into two groups based on the serum magnesium level. More patients who reported a serum magnesium level of ≤2.3 mg/dL significantly experienced dyslipidemia, higher level of hemoglobin, and lower serum sodium and tended to administrate beta-blockers, angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs), calcium channel blockers, and statin after admission [ 9 ]. These findings showed agreement and contrast with our findings; in agreement with our findings, we found that a higher proportion of AMI patients were suffering from dyslipidemia; however, the significance level was not definite (P=0.05).…”

Section: Discussionmentioning

confidence: 99%

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Serum Magnesium in Patients With Acute Myocardial Infarction and Its Effect on Cardiac Complications and Mortality in Myocardial Infarction Patients

Sabah¹,

Wani²,

Deajim³

et al. 2023

Cureus

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BackgroundMagnesium is an essential micronutrient for people and is crucial in maintaining healthy cardiac function. It functions as a cofactor in a number of the body's enzyme systems, and myocardial cells are one of its target tissues. The upkeep of the myocardium's normal functional integrity depends on a lot of things including magnesium ions.Magnesium plays an important role in the pathophysiology of cardiovascular disorders. AimThis study aims to estimate serum magnesium levels and their correlation with cardiac complications and mortality in patients with acute myocardial infarction (AMI). MethodsPatients with acute myocardial infarction who visited the Prince Faisal Bin Khalid Cardiac Center within 12 hours of the onset of symptoms were the subjects of this study. On the first and fifth days following admission, the level of serum magnesium was assessed. Statistical Package for Social Sciences (SPSS) version 20 (IBM SPSS Statistics, Armonk, NY) was used to analyze the collected data. ResultsThe current study comprised 160 patients with acute myocardial infarction; there were 84 (52.5%) who experienced a low level of serum magnesium on admission. Significantly higher proportions of patients who experienced low magnesium levels had diabetes mellitus (P=0.0072) and a history of diuretics (P=0.03) and were administrated beta-blockers (P=0.01), calcium channel blockers (P=0.04), and statins (P=0.007) after admission. Significantly higher proportions of patients with low serum magnesium experienced atrial fibrillation (P=0.03), angina (P=0.03), and cardiogenic shock (P=0.003). ConclusionLow magnesium levels are associated with poor outcomes in most patients admitted with acute myocardial infarction.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum Magnesium in Patients With Acute Myocardial Infarction and Its Effect on Cardiac Complications and Mortality in Myocardial Infarction Patients

Sabah¹,

Wani²,

Deajim³

et al. 2023

Cureus

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“…Notably, we observed increased rates of myocardial LGE—potential markers of minor myocardial infarction—in participants with high serum magnesium levels. It has been shown that in patients with acute coronary syndrome, there is a higher magnesium leakage from the infarcted myocardium leading to increased magnesium levels, with subsequent development of malignant ventricular arrhythmia and increased in-hospital deaths [ 47 , 48 ]. However, this cannot explain our findings since participants were not in an acute condition.…”

Section: Discussionmentioning

confidence: 99%

Subclinical Cardiovascular Disease Markers in Relation to Serum and Dietary Magnesium in Individuals from the General Population: The KORA-MRI Study

et al. 2022

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Several studies have implied a role of magnesium in the development of cardiovascular disease (CVD). Thus, magnesium might serve as a potential risk marker for early CVD. Therefore, we investigated the association of serum magnesium and dietary magnesium intake with markers of subclinical CVD in a population-based study. We used cross-sectional data from the sub-study of the Cooperative Health Research in the Region of Augsburg (KORA-FF4). Markers of subclinical CVD, namely, left and right ventricular structure and function and carotid plaque and carotid wall thickness, were derived by magnetic resonance imaging (MRI). Multivariable-adjusted regression models were applied to assess the relationship between serum and dietary magnesium and MRI-derived subclinical CVD markers. Among 396 included participants (mean age: 56.3 ± 9.2 years; 57.8% male), 181 (45.7%) had low serum magnesium levels (<2.07 mg/dl). Among 311 subjects with complete dietary data (mean age: 56.3 ± 9.1 years; 56.3% male), 154 (49.5%) had low dietary magnesium intake (≤155.2 mg/1000 kcal/day). Serum and dietary magnesium were not correlated (p-value = 0.5). Serum magnesium was significantly associated with presence of carotid plaque (OR 1.62, p-value 0.033). Dietary magnesium was associated with higher left ventricular end-systolic and end-diastolic volume (0.04 mL/m2, 0.06 mL/m2; p-value 0.011, 0.013, respectively), and also with a decrease in left ventricular remodeling index and mean diastolic wall thickness (−0.001 g/mL/m2, −0.002 mm/m2; p-value 0.004, 0.029, respectively). In summary, there was no consistent association of serum and dietary magnesium with imaging markers of subclinical CVD.

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“… 1 , 2 Malignant VA is one of the most common cause of death in patients with acute myocardial infarction (AMI). 3 , 4 Early revascularization can significantly improve the prognosis of AMI patients. 5 , 6 However, VA may still occur due to reperfusion myocardial injury or no-reflow.…”

Section: Introductionmentioning

confidence: 99%

“… 7–9 Thus, early assessment of VA risk in AMI patients can help clinicians to take active prevention and treatment measures, thus reducing the risk of in-hospital death and improving the prognosis. 4 , 10–12 In this study, we aimed to explore independent predictors of VA in AMI patients during hospitalization, and use them to develop a clinical prediction model.…”

Section: Introductionmentioning

confidence: 99%

A New Scoring System for Predicting Ventricular Arrhythmia Risk in Patients with Acute Myocardial Infarction

Han¹,

Wang²,

Zhu³

et al. 2023

CIA

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Objective In this study, a risk score for ventricular arrhythmias (VA) were evaluated for predicting the risk of ventricular arrhythmia (VA) of acute myocardial infarction (AMI) patients. Methods Patients with AMI were divided into two sets according to whether VA occurred during hospitalization. Another cohort was enrolled for external validation. The area under the curve (AUC) of receiver operating characteristic (ROC) was calculated to evaluate the accuracy of the model. Results A total of 1493 eligible patients with AMI were enrolled as the training set, of whom 70 (4.7%) developed VA during hospitalization. In-hospital mortality was significantly higher in the VA set than in the non-VA set (31.4% vs 2.7%, P=0.001). The independent predictors of VA in patients with AMI including Killip grade ≥3, STEMI patients, LVEF <50%, frequent premature ventricular beats, serum potassium <3.5 mmol/L, type 2 diabetes, and creatinine level. The AUC of the model for predicting VT/VF in the training set was 0.815 (95% CI: 0.763–0.866). A total of 1149 cases were enrolled from Xuzhou Center Hospital as the external validation set. The AUC of the model in the external validation set for predicting VT/VF was 0.755 (95% CI: 0.687–0.823). Calibration curves indicated a good consistency between the predicted and the observed probabilities of VA in both sets. Conclusion We have established a clinical prediction risk score for predicting the occurrence of VA in AMI patients. The prediction score is easy to use, performs well and can be used to guide clinical practice.

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Prognostic value of admission serum magnesium in acute myocardial infarction complicated by malignant ventricular arrhythmias

Cited by 7 publications

References 28 publications

Serum Magnesium in Patients With Acute Myocardial Infarction and Its Effect on Cardiac Complications and Mortality in Myocardial Infarction Patients

Serum Magnesium in Patients With Acute Myocardial Infarction and Its Effect on Cardiac Complications and Mortality in Myocardial Infarction Patients

Subclinical Cardiovascular Disease Markers in Relation to Serum and Dietary Magnesium in Individuals from the General Population: The KORA-MRI Study

A New Scoring System for Predicting Ventricular Arrhythmia Risk in Patients with Acute Myocardial Infarction

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