Prognostic value of a history of hypertension in 11483 patients with acute myocardial infarction treated with thrombolysis

Fresco, Claudio; Avanzini, Fausto; Bosi, Stefano; Franzosi, Maria Grazia; Maggioni, Aldo P.; Santoro, Luigi; Bellanti, Giancarlo

doi:10.1097/00004872-199606000-00010

Cited by 56 publications

(37 citation statements)

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“…Our study however, was by no means lacking in power compared with previous studies of this relationship before the introduction of ACE inhibitor treatment. The statistical power of our analysis to detect an adverse effect of antecedent hypertension on the mortality risk within the ACE inhibitor treatment arm was larger than all 2-4,6 but one 5 of the milestone studies that confirmed this association in the past.…”

Section: Prognostic Value Of Antecedent Hypertension After Amimentioning

confidence: 66%

“…[2][3][4][5] Of relevance to the AIRE study population is the observation that a history of hypertension increases the mortality risk at all levels of left ventricular ejection fraction and pulmonary congestion after AMI. 6 However, these associations were established by studies that had been conducted before the routine use of ACE inhibitors.…”

Section: Prognostic Value Of Antecedent Hypertension After Amimentioning

confidence: 99%

“…Several studies performed in the previous decade demonstrated that a history of antecedent hypertension is a negative independent prognostic factor after AMI. [2][3][4][5] In addition, the deleterious effect of a history of hypertension in post-AMI patients is highlighted by the fact that it increases the mortality risk at all levels of left ventricular (LV) ejection fraction and pulmonary con-gestion. 6 However, it is unknown whether antecedent hypertension retains its negative prognostic influence in contemporary post-AMI patients routinely treated with angiotensin-converting enzyme (ACE) inhibitor therapy.…”

Section: Introductionmentioning

confidence: 99%

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The prognostic significance of a history of systemic hypertension in patients randomised to either placebo or ramipril following acute myocardial infarction: evidence from the AIRE study

1999

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Background: After acute myocardial infarction (AMI), patients with a history of arterial hypertension (AH) have a worse prognosis than normotensives. Whether this adverse risk is beneficially modulated by treatment with angiotensin-converting enzyme (ACE) inhibitors is unknown. We evaluated the prognostic value of antecedent hypertension in post-AMI patients given ACE inhibitor therapy. Methods: We analysed retrospectively data from the AIRE study (randomised, placebo-controlled trial of ramipril in 2006 post-AMI patients with clinical heart failure). A history of AH was present in 28% of the patients. We examined the prognostic value of antecedent hypertension separately among placebo and ramipril treated patients and also the effect of ramipril on clinical outcomes according to whether or not a history of AH was present.

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Section: Prognostic Value Of Antecedent Hypertension After Amimentioning

confidence: 66%

Section: Prognostic Value Of Antecedent Hypertension After Amimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The prognostic significance of a history of systemic hypertension in patients randomised to either placebo or ramipril following acute myocardial infarction: evidence from the AIRE study

1999

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“…In the GISSI-2 study, in-hospital and 6-month mortality in hypertensive MI patients was significantly higher than for normotensives [10], as was the rate of left ventricular failure, recurrent angina and recurrent MI. In contrast, elevated blood pressure was not an independent prognostic factor for 30-day mortality among MI patients in the GUSTO-1 study [8].…”

Section: Discussionmentioning

confidence: 90%

“…Data on the impact of hypertension in patients with ST elevation myocardial infarction (STEMI) are so far inconsistent, and are mainly related to studies performed in the thrombolytic era [7,[9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Impact of hypertension on short- and long-term prognoses in patients with ST elevation myocardial infarction and without previously known diabetes

et al. 2011

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Hypertension is well established as a risk factor for the development of atherosclerosis. Data on the impact of hypertension in patients with ST elevation myocardial infarction are so far inconsistent, and are mainly related to studies performed in the thrombolytic era. We assessed the impact of hypertension over the short and long term in 560 patients with ST elevation myocardial infarction (STEMI) and without previously known diabetes, all of whom were submitted to mechanical revascularization and consecutively admitted to our Intensive Cardiac Care Unit. Hypertensive patients were older (p \ 0.001), more frequently male (0.005), and they showed a reduced eGFR (p \ 0.001).Smoking was more frequent in nonhypertensive patients (p \ 0.001), while the incidence of three-vessel coronary artery disease was higher in hypertensive patients (p = 0.003). No difference in the in-hospital mortality rates for the two subgroups was detected. At follow-up (median 32.5 months, 25th-75th percentile 16.9-47.3 months), Kaplan-Meier survival analysis detected no differences in mortality between hypertensive and nonhypertensive patients (log rank v 2 0.38, p = 0.538). According to our data, obtained from a large series of consecutive STEMI patients without previously known diabetes, all of whom were submitted to primary PCI, a history of hypertension does not affect mortality over either the short or the long term. Moreover, hypertensive patients showed an altered glucose response to stress, as indicated by higher admission glucose values, poorer in-hospital glucose control, and a higher incidence of acute insulin resistance (as indicated by the HOMA index). Hypertensive patients therefore appear to warrant careful metabolic management during their hospital courses.

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Importance of a history of hypertension for the prognosis after acute myocardial infarction‐‐‐for the bucindolol evaluation in acute myocardial infarction trial (BEAT) study group

Ali

Akman

Bruun

et al. 2004

Clinical Cardiology

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SummaryBackground: Arterial hypertension is a major risk factor for cardiovascular events. The prognosis for hypertensive patients after acute myocardial infarction (MI) is uncertain because of the sparse and somewhat contradictionary data.Hypothesis: Our study aimed to investigate the importance of hypertension to prognosis after an MI in patients receiving contemporary medical therapy.Methods: We performed a retrospective study using a large register from the Bucindolol Evaluation in Acute myocardial infarction Trial (BEAT). The register comprised 3,326 patients admitted between June 1998 and August 1999 with an enzyme-verified MI to 33 Danish coronary care units. Hypertension was considered present when a previous diagnosis of hypertension was accompanied by relevant medical therapy. Survival information for all patients was obtained in January 2002.Results: Of the 3,326 patients studied, 825 were hypertensive. Overall, 28.4% had died by January 2002. The unadjusted hazard ratio associated with hypertension was 1.2 (95% confidence limit [CI] 1.1-1.4, p = 0.004). Hypertensive patients were older, and after adjustment for age the hazard ratio

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Prognostic value of a history of hypertension in 11483 patients with acute myocardial infarction treated with thrombolysis

Cited by 56 publications

References 0 publications

The prognostic significance of a history of systemic hypertension in patients randomised to either placebo or ramipril following acute myocardial infarction: evidence from the AIRE study

The prognostic significance of a history of systemic hypertension in patients randomised to either placebo or ramipril following acute myocardial infarction: evidence from the AIRE study

Impact of hypertension on short- and long-term prognoses in patients with ST elevation myocardial infarction and without previously known diabetes

Importance of a history of hypertension for the prognosis after acute myocardial infarction‐‐‐for the bucindolol evaluation in acute myocardial infarction trial (BEAT) study group

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