Importance of a history of hypertension for the prognosis after acute myocardial infarction‐‐‐for the bucindolol evaluation in acute myocardial infarction trial (BEAT) study group

Ali, Irma; Akman, D; Bruun, Niels Eske; Køber, Lars; Brendorp, Bente; Ottesen, Michael; Møller, Jacob Eifer; Torp‐Pedersen, Christian

doi:10.1002/clc.4960270504

Cited by 13 publications

(8 citation statements)

References 32 publications

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“…The HTrelated results of this study were therefore expected, as similar results regarding early (b 30 days) mortality have been seen in previous studies of non-specific acute MI [23] and non-STEMI [9,10,24] and also in patients with coexisting DM [25].…”

Section: Discussionsupporting

confidence: 76%

“…Although the data from the literature are somewhat contradictory [9], previous studies have shown that hypertensive patients, especially younger individuals [11], run an increased risk of cardiovascular morbidity [21,22] and have a poorer outcome after an acute coronary event [12]. The HTrelated results of this study were therefore expected, as similar results regarding early (b 30 days) mortality have been seen in previous studies of non-specific acute MI [23] and non-STEMI [9,10,24] and also in patients with coexisting DM [25].…”

Section: Discussionmentioning

confidence: 91%

“…A number of studies have described the prognostic impact of a history of HT and a history of DM, mostly in patients with an acute MI [7][8][9][10][11][12][13][14][15]. The characteristics, treatment and outcome in hypertensive patients with and without DM in the full spectrum of ACS are less well known, although addressed in a few papers [16,17].…”

Section: Introductionmentioning

confidence: 96%

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Acute coronary syndromes — The prognostic impact of hypertension, diabetes and its combination on long-term outcome

Lingman¹,

Herlitz²,

Bergfeldt³

et al. 2009

International Journal of Cardiology

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 96%

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Acute coronary syndromes — The prognostic impact of hypertension, diabetes and its combination on long-term outcome

Lingman¹,

Herlitz²,

Bergfeldt³

et al. 2009

International Journal of Cardiology

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“…The literature on the effect of hypertension on short-and long-term mortality is conflicting; many studies have claimed a deleterious effect of hypertension in ACS with an increasing risk of death [11][12][13] while others, including the current study and Gulf RACE-1, failed to show this [6][7][8][9][11][12][13][14][15][16][17][18][19]. Other investigators reported better outcomes in hypertensive patients presenting with ACS [20,21].…”

Section: Discussionmentioning

confidence: 43%

In-hospital complications and 1-year outcome of acute coronary syndrome in patients with hypertension: findings from the 2nd Gulf Registry of Acute Cardiac Events

Ali

Habib²,

Hersi³

et al. 2012

Easter Mediterr Health J

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Using data from the 2nd Gulf Registry of Acute Coronary Events (Gulf RACE-2) in 2008-09 we investigated the in-hospital complications and 1-year outcome of acute coronary syndrome (ACS) in patients with systemic hypertension from 6 Gulf countries. Of 7847 consecutive patients admitted with ACS, 3746 (47.7%) had hypertension. Hypertension was more prevalent in women, in Arabs than non-Arabs and in older age groups. Patients with hypertension were more likely than those without hypertension to present with dyspnoea and advanced Killip class. Among hypertensive patients, the mortality rate was higher only among those admitted with ST-elevation myocardial infarction. After adjustment for baseline variables, hypertension was an independent predictive factor for heart failure (OR = 1.31) and stroke (OR = 2.47). There were no significant differences in mortality in hypertensive ACS patients when stratified by sex, age or ethnicity.1 Department of Cardiology and Cardiovascular Surgery, Hamad General Hospital and Weill Cornell Medical School, Doha, Qatar (Correspondence to J. Al Suwaidi: jalsuwaidi @hotmail.com

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“…Those who had hyperglycemia and DM were 29%. The incidence of hyperglycemia with DM varies in different studies between 23%–41% 12,13. Thirty two percent had history of hypertension, which is higher than those previously reported (28% and 25%) in other studies, respectively 14,15…”

Section: Discussionmentioning

confidence: 70%

The Threshold of Admission Glycemia as a Predictor of Adverse Events in Diabetic and Non-Diabetic Patients with Acute Coronary Syndrome

Garadah

Kassab

Al-Shboul

et al. 2009

Clinical medicine. Cardiology

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Recent studies indicated a high prevalence of hyperglycemia in non-diabetic patients presenting with acute coronary syndrome (ACS). However, the threshold of admission glucose (AG) as a predictor of adverse events in ACS is unclear.Objective: The aim of this study was to assess the threshold of admission glucose (AG) as a predictor of adverse events including Major Acute Cardiac Events (MACE) and mortality, during the fi rst week of admitting patients presenting with ACS. Material and Methods:The data of 551 patients with ACS were extracted and evaluated. Patients were stratifi ed according to their blood glucose on admission into three groups: group 1: Յ7 mmol/L (n = 200, 36.3%) and group 2: Ͼ7 mmol/L and Ͻ15 mmol/L (n = 178, 32.3%) and group 3: Ն15 mmol/L (n = 173, 31.4%). Stress hyperglycemia was arbitrarily defi ned as AG levels Ͼ 7 mmol/L (group 2 and 3). Patients with ACS were sub-divided into two groups: patients with unstable angina (UA, n = 285) and those with ST segment elevation myocardial Infarction (STEMI, n = 266) and data were analyzed separately using multiple regression analysis. Results:The mean age of patients was 59.7 ± 14.8 years and 63% were males. The overall mortality in the population was 8.5% (5.4% in STEMI and 3.1% in UA) patients. In STEMI patients, the odds ratio of stress hyperglycemia as predictor of mortality in group 3 compared with group 1 was 3.3 (CI 0.99-10.98, P Ͻ 0.05), while in group 2 compared with group 1 was 2.4 (CI: 0.75-8.07, P = 0.065) after adjustment for age and sex. Similarly, in UA patients, the odds ratio of stress hyperglycemia in group 3 compared with group 1 was 2.7 (CI 0.37-18.98, P Ͻ 0.05), while in group 2 compared with group 1 was 2.4 (CI: 0.4-15.2, P = 0.344) after adjustment for age and sex. The incidence of more than 2 MACE in both STEMI and UA patients was higher in group 3 compared with the other two groups. Regression analysis showed that history of DM, high level of LDL cholesterol, high level of HbA1c, and anterior infarction were signifi cant predictors of adverse events while other risk factors such as BMI, history of hypertension and smoking were of no signifi cance. Conclusion:This study indicates that the stress hyperglycemia on admission is a powerful predictor of increased major adverse events and hospital mortality in patients with acute coronary syndrome.

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Importance of a history of hypertension for the prognosis after acute myocardial infarction‐‐‐for the bucindolol evaluation in acute myocardial infarction trial (BEAT) study group

Cited by 13 publications

References 32 publications

Acute coronary syndromes — The prognostic impact of hypertension, diabetes and its combination on long-term outcome

Acute coronary syndromes — The prognostic impact of hypertension, diabetes and its combination on long-term outcome

In-hospital complications and 1-year outcome of acute coronary syndrome in patients with hypertension: findings from the 2nd Gulf Registry of Acute Cardiac Events

The Threshold of Admission Glycemia as a Predictor of Adverse Events in Diabetic and Non-Diabetic Patients with Acute Coronary Syndrome

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