Prognostic study for overall survival in patients with newly diagnosed POEMS syndrome

Abstract

POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) is a multisystem disorder with a good long-term prognosis. In its dozens of clinical features, those with independent prognostic value are still not well characterized. We retrospectively included 362 patients with newly diagnosed POEMS syndrome at our institute from 2000 to 2015. On the basis of a randomized sample splitting, we first identified four baseline clinical variables, including age >50 years (hazards ratio (HR) 4.07, 95% confidence interval (CI) 1.41-11.76, P=0.009), pulmonary hypertension (HR 3.99, 95% CI 1.44-11.04, P=0.008), pleural effusion (HR 3.81, 95% CI 1.23-11.79, P=0.02) and estimated glomerular filtration rate <30 ml/min/1.73 m (HR 8.25, 95% CI 2.18-31.25, P=0.002), associated with inferior overall survival in the derivation cohort, with the use of multivariate Cox regression model. These factors were incorporated together to develop a prognostic nomogram. Concordance index calculation (0.727, 95% CI 0.601-0.853, P=0.018) and calibration curve plotting demonstrated its significant predictive and discriminatory capacity in the validation cohort. This nomogram could be a useful and convenient tool in clinical practice to evaluate individualized prognosis in patients with newly diagnosed POEMS syndrome.

High‐dose therapy and autologous transplantation for POEMS Syndrome: effective, but how to optimise?

“…This analysis confirms high rates of overall survival and PFS following transplantation (Karam et al, 2015;Kourelis et al, 2016a;Cook et al, 2017;Ohwada et al, 2018;D'Souza et al, 2012). Our experience confirms that attainment of HR CR following ASCT in POEMS syndrome is associated with a significantly lower rate of relapse (Kourelis et al, 2016b;Wang et al, 2017;Ohwada et al, 2018). The median time to confirmed HR CR was 5Á5 months, demonstrating that the success of ASCT can often be determined soon after therapy and allows for early relapse risk stratification.…”

Circular RNA circMTO1 acts as the sponge of microRNA‐9 to suppress hepatocellular carcinoma progression

“…D). Furthermore, we also used the K ‐adaptive partitioning statistical (kaps) algorithm in R software to calculate the most efficient cut‐off value of circMTO1 expression (76.89), which can most significantly distinguish the outcomes of these HCC patients (Fig. E).…”

A prospective phase II study of low dose lenalidomide plus dexamethasone in patients with newly diagnosed polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome

“…Patients were stratified into different risk categories . Patients were assigned one point for each of the following: age > 50 years, presence of PAH, presence of pleural effusions and two points for eGFR< 30 mL/min/1.73 m 2 .…”