Prognostic significance of vascular invasion and cell-proliferation activity in widely invasive follicular carcinoma of the thyroid

Ito, Yasuhiro; Hirokawa, Mitsuhiro; Fujishima, Makoto; Masuoka, Hiroo; Higashiyama, Takuya; Kihara, Minoru; Onoda, Naoyoshi; Miya, Akihiro; Miyauchi, Akira

doi:10.1507/endocrj.ej21-0064

Cited by 6 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Due to the vascular invasiveness of FTC, it is more likely to metastasize to distant organs and not only to regional lymph nodes 25 . Some studies have indicated that WIFTC is a poorer prognosis than MIFTC, which is consistent with our study 26,27 . Other research has found no significant difference in disease‐free survival between patients with MIFTC who underwent thyroidectomy alone and those who received thyroidectomy and radioiodine therapy after thyroidectomy 28 .…”

Section: Discussionsupporting

confidence: 87%

“… 25 Some studies have indicated that WIFTC is a poorer prognosis than MIFTC, which is consistent with our study. 26 , 27 Other research has found no significant difference in disease‐free survival between patients with MIFTC who underwent thyroidectomy alone and those who received thyroidectomy and radioiodine therapy after thyroidectomy. 28 This is another evidence of the better prognosis of MIFTC.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prognosis and influencing factors of follicular thyroid cancer

Shen,

Yan,

Chen

et al. 2023

Cancer Medicine

View full text Add to dashboard Cite

ObjectivesFollicular thyroid cancer (FTC) is prone to distant metastasis, and patients with distant metastasis often have poor prognosis. In this study, the impact of metastasis and other relevant factors on the prognosis of follicular thyroid carcinoma was examined.MethodsThis was a retrospective study. Data were obtained from Zhejiang Cancer Hospital, Sun Yat‐sen University Cancer Center and Hangzhou First People's Hospital affiliated with Zhejiang University School of Medicine, from January 2009 to June 2021 for 153 FTC patients. The patients were assigned into three groups according to their distant metastasis: distant metastasis at initial diagnosis (M1), distant metastasis during follow‐up (M2), and no evidence of distant metastasis over the course of the study (M0). Data were collected and summarized on clinical data, laboratory parameters, imaging features, postoperative pathologic subtypes, and metastases. The Cox proportional hazard model was used to perform the univariate and multivariate analysis. Kaplan–Meier curves were used to evaluate cancer‐specific survival (CSS).ResultsBased on metastasis, the patients were assigned into three groups, including 31 in the M1 group, 15 in the M2 group, and 107 in the M0 group. These individuals were followed up for an average of 5.9 years, and the group included 46 patients with distant metastasis (31 confirmed at diagnosis and 15 found during follow‐up). Univariate Cox regression analysis showed that age, Hashimoto's thyroiditis (HT), surgery method, postoperative adjuvant therapy, histologic subtype, nodule size, calcification, TSH, and distant metastasis all impacted prognosis. Multivariate Cox regression analysis suggested that histologic subtype (widely invasive; HR: 7.440; 95% CI: 3.083, 17.954; p < 0.001), nodule size (≥40 mm; HR: 8.622; 95% CI: 3.181, 23.369; p < 0.001) and distant metastasis (positive; HR: 6.727; 95% CI: 2.488, 18.186; p < 0.001) were independent risk factors affecting the prognosis of follicular thyroid cancer.ConclusionsHistologic subtype, nodule size, and distant metastasis are important risk factors for the prognosis of follicular thyroid cancer. Patients with metastatic follicular thyroid cancer have a poor prognosis, especially with metastasis at the time of initial diagnosis. As a result, this group of patients requires individualized treatment and closer follow‐up.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Prognosis and influencing factors of follicular thyroid cancer

Shen,

Yan,

Chen

et al. 2023

Cancer Medicine

View full text Add to dashboard Cite

show abstract

“…On the contrary, the impact of VI in WI‐FTC is yet to be fully investigated. Ito et al reported that the WI‐FTC patients with VI showed a significantly poorer RFS rate than those without VI [16]. Furthermore, no statistical difference in distant RFS between MI‐FTC and WI‐FTC without VI was present [12].…”

Section: Discussionmentioning

confidence: 99%

New Insights on the Importance of the Extent of Vascular Invasion in Widely Invasive Follicular Thyroid Carcinoma

et al. 2023

View full text Add to dashboard Cite

Background This study aimed to investigate the association between the extent of vascular invasion (VI) and the outcome of widely invasive follicular thyroid carcinoma (WI-FTC). Methods The records of 107 patients with WI-FTC confirmed by surgical specimens from January 2005 to December 2016 were retrospectively reviewed. Results Among the 107 patients with WI-FTC, those with a VI of \ 4 (n = 62) and C 4 (n = 45) had a 10 year cause-specific survival (CSS) rate of 97.7% and 89.4% (p = 0.008), respectively. Univariate analysis identified M1 (p = 0.001), and the number of VI of C 4 as significant negative prognostic factors for CSS. Multivariate analysis identified M1 (hazard ratio [HR] = 9.366) as independent negative prognostic factor for CSS. Among the 72 patients with M0 WI-FTC, those with a VI of \ 2 (n = 33) and C 2 (n = 39) had a 10-year distant metastasis-free survival (DMFS) rate of 96.8% and 56.8% (p = 0.001), respectively. Univariate analysis identified age C 55 years (p = 0.011), presence of VI, the number of VI of C 2, and resection margin status (p \ 0.001) as significant negative prognostic factors for DMFS. Multivariate analysis identified the number of VI C 2 (HR = 9.137), and resection margin status (HR = 5.853) as independent negative prognostic factors for DMFS. Conclusions It may be unnecessary that WI-FTC with curative resection margin status and a VI of \ 2, especially in capsular invasion only, routinely undergo completion thyroidectomy and postoperative ablation.

show abstract

“…The prognostic role of Ki67 index in widely invasive follicular carcinoma has been explored as well. Although Ki67 index > 5% seems associated with high risk of recurrence, there are not sufficient data supporting its powerful when compared with other markers such as vascular invasion [35].…”

Section: Thyroid Tumorsmentioning

confidence: 96%

Diagnostic, Prognostic, and Predictive Role of Ki67 Proliferative Index in Neuroendocrine and Endocrine Neoplasms: Past, Present, and Future

Rosa

2023

Endocr Pathol

View full text Add to dashboard Cite

The introduction of Ki67 immunohistochemistry in the work-up of neuroendocrine neoplasms (NENs) has opened a new approach for their diagnosis and prognostic evaluation. Since the first demonstration of the prognostic role of Ki67 proliferative index in pancreatic NENs in 1996, several studies have been performed to explore its prognostic, diagnostic, and predictive role in other neuroendocrine and endocrine neoplasms. A large amount of information is now available and published results globally indicate that Ki67 proliferative index is useful to this scope, although some differences exist in relation to tumor site and type. In gut and pancreatic NENs, the Ki67 proliferative index has a well-documented and accepted diagnostic and prognostic role and its evaluation is mandatory in their diagnostic work-up. In the lung, the Ki67 index is recommended for the diagnosis of NENs on biopsy specimens, but its diagnostic role in surgical specimens still remains to be officially accepted, although its prognostic role is now well documented. In other organs, such as the pituitary, parathyroid, thyroid (follicular cell-derived neoplasms), and adrenal medulla, the Ki67 index does not play a diagnostic role and its prognostic value still remains a controversial issue. In medullary thyroid carcinoma, the Ki67 labelling index is used to define the tumor grade together with other morphological parameters, while in the adrenal cortical carcinoma, it is useful to select patients to treated with mitotane therapy. In the present review, the most important information on the diagnostic, prognostic, and predictive role of Ki67 proliferative index is presented discussing the current knowledge. In addition, technical issues related to the evaluation of Ki67 proliferative index and the future perspectives of the application of Ki67 immunostaining in endocrine and neuroendocrine neoplasms is discussed.

show abstract

Prognostic significance of vascular invasion and cell-proliferation activity in widely invasive follicular carcinoma of the thyroid

Cited by 6 publications

References 15 publications

Prognosis and influencing factors of follicular thyroid cancer

Prognosis and influencing factors of follicular thyroid cancer

New Insights on the Importance of the Extent of Vascular Invasion in Widely Invasive Follicular Thyroid Carcinoma

Diagnostic, Prognostic, and Predictive Role of Ki67 Proliferative Index in Neuroendocrine and Endocrine Neoplasms: Past, Present, and Future

Contact Info

Product

Resources

About