Prognostic significance of the right ventricular function in patients with CHF

Сумин, А. Н.; Arkhipov, O. G.

doi:10.18087/rhfj.2017.3.2340

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…По данным ЭхоКГ у пациентов 2 группы исходно были отмечены большие размеры ПЖ, прогностическая значимость которого обсуждается в литературе [13], а также были выявлены значимо более высокие цифры СДЛА исходно и в динамике. На фоне СРТ степень изменения объема ПП была противоположной в группах -уменьшалась в 1 группе и увеличивалась во 2 группе.…”

Section: обсуждение полученных результатовunclassified

Multimarker approach for assessing efficiency of cardiac resynchronization therapy in patients with sinus rhythm

Кузнецов

Enina

Солдатова

et al. 2020

Vestnik aritmologii

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Purpose: to design mathematical model, that can predict positive response to cardiac resynchronization therapy (CRT) in patients with congestive heart failure (CHF) and sinus rhythm, according to complex analysis of neurohumoral and immune activation biomarkers, fibrosis, renal dysfunction, echocardiography.Material and methods: parameters of echocardiography, plasma levels of NT-proBNP, interleukins-1β, 6, 10, tumor necrosis factor α, С-reactive protein (СRP), matrix metalloproteinase-9 (ММР-9), tissue inhibitors of metalloproteinase 1 and 4, cystatin С (CYSTATIN) were studied in 40 CHF patients with sinus rhythm (65% coronary artery disease patients, 75% males, mean age 54.8±10.6 years old) during the period of maximum decrease of left ventricular end-systolic volume (LVESV) (mean duration 27.5 [11.1; 46.3] months). Responders (decrease in LVESV ≥15%) and non-responders (decrease in LVESV ˂15%) were identified.Results: the number of responders was 26 (65%). Initial set of variables included: age, left ventricular ejection fraction (EF), systolic pressure in the pulmonary artery, right ventricle size and NT-proBNP, СRP, ММР-9, CYSTATIN. According to logistic regression analysis, a model was created: F=3.231 + 0.344 х EF - 3.479 x CYSTATIN - 0.039 х ММР-9 - 0.638 х CRР. Prediction of response to CRT (P) was carried out using the equation: Р=1/(1+е(-F)); a less than 0.696 p-value was associated with membership of non-responders group; p-value greater than or equaled to 0.696 was associated with group of responders. The specificity of the model was 92.9%, sensitivity - 83.3%, AUC=0.952 (р˂0.001).Conclusions: the proposed model, based on assessment of left ventricular EF and laboratory data, that reflect key mechanisms of development and progression of CHF - immune inflammation, fibrosis, renal dysfunction, suggests a possible response to CRT.

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Section: обсуждение полученных результатовunclassified

Multimarker approach for assessing efficiency of cardiac resynchronization therapy in patients with sinus rhythm

Кузнецов

Enina

Солдатова

et al. 2020

Vestnik aritmologii

View full text Add to dashboard Cite

show abstract

Multimarker approach for assessing efficiency of cardiac resynchronization therapy in patients with sinus rhythm

Кузнецов

Enina

Солдатова

et al. 2021

Vestnik aritmologii

View full text Add to dashboard Cite

Purpose. To design a mathematical model, that can predict a positive response to cardiac resynchronization therapy (CRT) in patients with congestive heart failure (CHF) and sinus rhythm, according to complex analysis of neurohumoral and immune activation biomarkers, fibrosis, renal dysfunction, echocardiography.Methods. Parameters of echocardiography, plasma levels of NT-proBNP, interleukins-1β, 6, 10, tumor necrosis factor α, С-reactive protein (СRP), matrix metalloproteinase-9 (ММР-9), tissue inhibitors of metalloproteinase 1 and 4, cystatin С (CYSTATIN) were studied in 40 CHF patients with sinus rhythm (65% coronary artery disease patients, 75% males, mean age 54.8±10.6 years old) during the period of maximum decrease of left ventricular end-systolic volume (LVESV) (mean duration 27.5 [11.1; 46.3] months). Responders (decrease in LVESV ≥15%) and non-responders (decrease in LVESV <15%) were identified.Results. The number of responders was 26 (65%). The initial set of variables included: age, left ventricular ejection fraction (EF), pulmonary artery systolic pressure, right ventricle size and NT-proBNP, СRP, ММР-9, CYSTATIN. According to logistic regression analysis, a prediction model of positive CRT response was created. The specificity of the model was 92.9%, sensitivity - 83.3%, AUC=0.952 (р˂0.001).Conclusion. The proposed model, based on the assessment of left ventricle EF and circulating biomarkers of inflammation, fibrosis, and renal function, strongly suggests a higher possibility of response to CRT.

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Prognostic significance of the right ventricular function in patients with CHF

Cited by 2 publications

References 24 publications

Multimarker approach for assessing efficiency of cardiac resynchronization therapy in patients with sinus rhythm

Multimarker approach for assessing efficiency of cardiac resynchronization therapy in patients with sinus rhythm

Multimarker approach for assessing efficiency of cardiac resynchronization therapy in patients with sinus rhythm

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