Prognostic significance of the lymphocyte-to-monocyte ratio in patients with malignant pleural mesothelioma

Yamagishi, Tomoko; Fujimoto, Nobukazu; Nishi, Hideyuki; Miyamoto, Yukio; Hara, Naofumi; Asano, Michiko; Fuchimoto, Yasuko; Wada, Sae; Kitamura, K.; Ozaki, Shinji; Kishimoto, Takumi

doi:10.1016/j.lungcan.2015.07.014

Cited by 58 publications

(42 citation statements)

References 32 publications

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“…Therefore, NLR may represent an innovative, precise, and repeatable laboratory parameter to identify TNBC patients with poorer prognosis. Our data confirmed previous reports in which NLR was shown to have prognostic value in various other cancers, such as non‐small‐cell lung, gynecological, urological, and gastrointestinal cancers, and soft‐tissue sarcoma, .…”

Section: Discussionsupporting

confidence: 91%

Increased neutrophil–lymphocyte ratio independently predicts poor survival in non‐metastatic triple‐negative breast cancer patients

et al. 2018

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Inflammation plays an important role in tumor initiation, progression, and metastasis. The neutrophil-lymphocyte ratio (NLR) is widely used to evaluate global inflammation in various tumor types. However, the prognostic role of NLR in non-metastatic triple-negative breast cancer (TNBC) patients was poorly known. The aim of this study was to explore the association between pre-treatment NLR and survival in TNBC patients. Data were collected for patients with stages I-III TNBC from 2006 to 2013 at Linyi Central Hospital to analyze pre-treatment NLR and survival. Overall survival (OS) and disease-free survival (DFS) were estimated by the Kaplan-Meier method, and Cox analysis was performed to determine clinicopathological parameters for their prognostic relevance. A total of 406 patients were eligible. Patients with NLR lower than 2.85 exhibited significantly higher OS (P < 0.001) and DFS (P < 0.001) than patients with higher NLR. Higher pre-treatment NLR was independently correlated with poor OS and DFS, with hazard ratios of 2.69 (95% confidence interval [CI]: 1.94-3.72, P = 0.001) and 2.13 (95% CI: 1.68-2.65, P = 0.008), respectively, in the Cox proportional multivariate hazard model. In conclusion, our results indicate that pre-treatment NLR may be correlated with OS and DFS in early-stage TNBC patients, and that it may have considerable clinical applications. © 2018 IUBMB Life, 70(6):529-535, 2018.

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Section: Discussionsupporting

confidence: 91%

Increased neutrophil–lymphocyte ratio independently predicts poor survival in non‐metastatic triple‐negative breast cancer patients

et al. 2018

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“…Similar to our study, comparisons among NLR, PLR, and LMR have been reported for a number of other cancer sites. NLR was considered an independent prognostic factor in patients with gastric cancer, colorectal cancer, and colorectal liver metastasis, whereas LMR was considered an independent prognostic factor in patients with bladder cancer, esophageal cancer, and malignant pleural mesothelioma . Meta‐analysis is required to clarify which inflammatory marker is the most valuable for each cancer site.…”

Section: Discussionmentioning

confidence: 99%

“…NLR was considered an independent prognostic factor in patients with gastric cancer, colorectal cancer, and colorectal liver metastasis, whereas LMR was considered an independent prognostic factor in patients with bladder cancer, esophageal cancer, and malignant pleural mesothelioma. [4][5][6][7][8][9] Meta-analysis is required to clarify which inflammatory marker is the most valuable for each cancer FIGURE 5. Overall survival (OS) curves in 4 groups stratified according to lymphocyte-to-monocyte ratio (LMR) and neutrophilto-lymphocyte ratio (NLR), or LMR and platelet-to-lymphocyte ratio (PLR) level.…”

Section: Discussionmentioning

confidence: 99%

“…Since Virchow noted the presence of leukocytes in neoplastic tissues and made a connection between inflammation and cancer in 1863, the association between oncogenesis and a systemic inflammatory response has been gradually clarified . Recently, it has been reported that inflammatory cells in the peripheral blood are associated with the prognosis in many cancer sites, with the results suggesting that inflammatory cells in the tumor microenvironment play a significant role in tumor development . The peripheral blood neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), and lymphocyte‐to‐monocyte ratio (LMR) have been widely investigated as useful predictors of prognosis for various cancers, including head and neck cancers.…”

Section: Introductionmentioning

confidence: 99%

“…3 Recently, it has been reported that inflammatory cells in the peripheral blood are associated with the prognosis in many cancer sites, with the results suggesting that inflammatory cells in the tumor microenvironment play a significant role in tumor development. [4][5][6][7][8][9] The peripheral blood neutrophil-tolymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) have been widely investigated as useful predictors of prognosis for various cancers, including head and neck cancers. However, most of the studies on inflammatory markers in head and neck cancers have targeted cancers of the nasopharynx or oral cavity, with few studies conducted on other head and neck cancers, including oropharyngeal, hypopharyngeal, and laryngeal cancers.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pretreatment lymphocyte‐to‐monocyte ratio as an independent prognostic factor for head and neck cancer

et al. 2016

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Diagnostic and prognostic value of preoperative systemic inflammatory markers in anaplastic thyroid cancer

Zhang

Luo

Wang

et al. 2020

Journal of Surgical Oncology

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Background Easily accessible, generalized, and inexpensive methods are expected to differentiate anaplastic thyroid carcinoma (ATC) from advanced differentiated thyroid cancer (aDTC). We aimed to explore potential diagnostic and prognostic value of systematic inflammatory markers (SIMs) in ATC and aDTC. Methods About 22 ATC, 101 aDTC, and 100 matched early DTC patients were analyzed retrospectively. SIMs included the comprehensive index, neutrophil‐monocyte‐platelet‐to‐lymphocyte ratio (NMPLR) and the previously reported ones. Receiver operating characteristic, Kaplan‐Meier, and COX regression analyses were mainly conducted. Results NMPLR exhibited the highest area under the curve value 0.806 (P < .0001) to diagnose ATC from aDTC. NMPLR was identified as an independent risk factor for overall survival (OS) (hazard ratio [HR]: 47.821, 95% confidence interval [CI], 2.863‐798.765, P = .007) in ATC, as well as for OS (HR: 7.360, 95% CI, 1.620‐33.430, P = .010) and recurrence‐free survival (HR: 4.172, 95% CI, 1.139‐15.286, P = .031) in aDTC. Taken both refractory types (ATC and aDTC) together, NMPLR could independently predict OS (HR: 6.470; 95% CI, 2.134‐19.616; P = .001). Conclusion NMPLR is a generalized index. It showed excellent potential in differential diagnosis and survival prediction in refractory thyroid cancer. However, it needs to be validated in larger cohort and clinical practice.

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Prognostic significance of the lymphocyte-to-monocyte ratio in patients with malignant pleural mesothelioma

Cited by 58 publications

References 32 publications

Increased neutrophil–lymphocyte ratio independently predicts poor survival in non‐metastatic triple‐negative breast cancer patients

Increased neutrophil–lymphocyte ratio independently predicts poor survival in non‐metastatic triple‐negative breast cancer patients

Pretreatment lymphocyte‐to‐monocyte ratio as an independent prognostic factor for head and neck cancer

Diagnostic and prognostic value of preoperative systemic inflammatory markers in anaplastic thyroid cancer

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