Prognostic significance of Survivin and CD44v6 in laryngeal cancer surgical margins

Zhao, Hou-Yu; Ren, Jie; Zhuo, Xianlu; Ye, Huiping; Zou, Jian; Liu, Shixi

doi:10.1007/s00432-008-0391-5

Cited by 23 publications

(25 citation statements)

References 15 publications

(16 reference statements)

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“…Recently, Zhao et al reported that immunohistochemical assessment of CD44v6 in a negative surgical margin would be a valuable approach for predicting recurrence and survival after curative surgery for laryngeal cancer (36). Some authors showed that CD44v6 could be associated with cancer progression, metastasis, and recurrence (36,46). Our data indicate that CD44v6 expression is associated with regional lymph node metastasis, POI, NAC, DOI, perineural invasion, and local recurrence in OTSCC.…”

Section: Discussionsupporting

confidence: 52%

“…It was also hypothesized in the mechanism of tumor local recurrence that this elevated risk may be due to undetected tumor cells present in surgical margins thought to be negative by conventional light microscopy (9-11). Recently, to improve the detection of residual cancer cells or tumor-related precursor lesions remaining in histologically negative margins, molecular margin analysis was proposed and has now been used to observe and predict local recurrence of head and neck cancers (9,12,36). We therefore focused on the expression of molecules relevant to CSCs in tumor satellites at the tumor/ host interface.…”

Section: Discussionmentioning

confidence: 99%

“…The variant 6 isoform (CD44v6), in particular, is associated with several cancer types but not in somatic cells (15,(18)(19)(20)(21). Moreover, CD44v6 is widely known as a marker of CSCs (18,21,36,(44)(45)(46). Recently, Zhao et al reported that immunohistochemical assessment of CD44v6 in a negative surgical margin would be a valuable approach for predicting recurrence and survival after curative surgery for laryngeal cancer (36).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, CD44v6 is widely known as a marker of CSCs (18,21,36,(44)(45)(46). Recently, Zhao et al reported that immunohistochemical assessment of CD44v6 in a negative surgical margin would be a valuable approach for predicting recurrence and survival after curative surgery for laryngeal cancer (36). Some authors showed that CD44v6 could be associated with cancer progression, metastasis, and recurrence (36,46).…”

Section: Discussionmentioning

confidence: 99%

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Expression of the cancer stem cell markers CD44v6 and ABCG2 in tongue cancer: Effect of neoadjuvant chemotherapy on local recurrence

Yanamoto

Yamada

Takahashi

et al. 2014

International Journal of Oncology

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Abstract. The efficacy of neoadjuvant chemotherapy (NAC) is controversial, and no report supports NAC with a high evidence level. Recently, we showed that a deep surgical margin was resected very close to the tumor site in many NAC-treated oral squamous cell carcinoma patients, suggesting that NAC may lead to local recurrence and poor outcomes. The purpose of this study was to evaluate the effect of NAC on tumor local recurrence using cancer stem cell marker immunohistochemistry. We retrospectively analyzed 89 patients who underwent radical surgery for tongue cancer, and examined the effect of NAC on tumor local recurrence. Cancer stem cell marker (CD44v6 and ABCG2) expression was detected by immunohistochemistry. In our study, the local recurrence rate was 12.4%. CD44v6 and ABCG2 expression was significantly associated with regional lymph node metastasis, pattern of invasion, depth of invasion, perineural invasion and local recurrence, respectively. Tumor local recurrence was a significant independent predictive factor of the 5-year disease specific survival. CD44v6 or ABCG2 positivity in NAC-treated patients was significantly associated with tumor local recurrence. It was suggested that local recurrence in NAC-treated cases is associated with cancer stem-like cells. We propose that NAC leads to the selection and/or residue of more aggressive cancer stem-like cells.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Expression of the cancer stem cell markers CD44v6 and ABCG2 in tongue cancer: Effect of neoadjuvant chemotherapy on local recurrence

Yanamoto

Yamada

Takahashi

et al. 2014

International Journal of Oncology

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“…Kawano et al found CD44s and CD44v6 staining correlated with prognosis in a series of 57 patients treated with surgery and radiotherapy (35). Zhao et al analyzed margins after surgery for 112 HNSCC patients and found that CD44v6 presence in these margins, detected with immunohistochemistry, was predictive of recurrence (36). Wang et al (37) found that one CD44 isoform (v10) was associated with reduced disease free survival in HNSCC.…”

Section: Discussionmentioning

confidence: 99%

CD44 Expression Predicts Local Recurrence after Radiotherapy in Larynx Cancer

Jong

Pramana

Wal

et al. 2010

Clinical Cancer Research

157

102

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Purpose: To find molecular markers from expression profiling data to predict recurrence of laryngeal cancer after radiotherapy.Experimental Design: We generated gene expression data on pre-treatment biopsies from 52 larynx cancer patients. Patients developing a local recurrence were matched for T-stage, subsite, treatment, gender and age with non-recurrence patients. Candidate genes were then tested by immunohistochemistry on tumor material from a second series of 76 patients. Both series comprised early stage cancer treated with radiotherapy alone. Finally, gene expression data of eight larynx cancer cell lines with known radiosensitivity were analyzed.Results: Nineteen patients with a local recurrence were matched with 33 controls. Gene sets for hypoxia, proliferation and intrinsic radiosensitivity did not correlate with recurrence, whereas expression of the putative stem cell marker CD44 did. In a supervised analysis, probes for all three splice variants of CD44 on the array appeared in the top 10 most significantly correlated with local recurrence. Immunohistochemical analysis of CD44 expression on the independent validation series confirmed CD44's predictive potential. In 8 larynx cancer cell lines, CD44 gene expression did not correlate with intrinsic radiosensitivity although it did correlate significantly with plating efficiency, consistent with a relationship with stem cell content.Conclusions: CD44 was the only biological factor tested which significantly correlated with response to radiotherapy in early stage larynx cancer patients, both at the mRNA and protein levels. Further studies are needed to confirm this and to assess how general these findings are for other head and neck tumor stages and sites. Clin Cancer Res; 16(21); 5329-38. ©2010 AACR.

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Surgical Margins in the Genomic Era

Wolf¹

2012

Arch Otolaryngol Head Neck Surg

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Prognostic significance of Survivin and CD44v6 in laryngeal cancer surgical margins

Abstract: Immunohistochemical assessment of both Survivin and CD44v6 status in negative surgical margin may be a valuable approach for predicting recurrence and survival after curative surgery for laryngeal cancer.

Cited by 23 publications

References 15 publications

Expression of the cancer stem cell markers CD44v6 and ABCG2 in tongue cancer: Effect of neoadjuvant chemotherapy on local recurrence

Expression of the cancer stem cell markers CD44v6 and ABCG2 in tongue cancer: Effect of neoadjuvant chemotherapy on local recurrence

CD44 Expression Predicts Local Recurrence after Radiotherapy in Larynx Cancer

Surgical Margins in the Genomic Era

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