Surgical Margins in the Genomic Era

Wolf, Gregory T.

doi:10.1001/2013.jamaoto.82

Cited by 14 publications

(13 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…EMT is also a characteristic of cancer initiating stem cells that may be responsible for tumor recurrence and treatment resistance [13,14]. The identification of cancer stem cells in HNSCC [15] that are associated with epithelial to mesenchymal transition and tumor invasiveness, metastasis and resistance to therapy prompted us to hypothesize that the degree of EMT in a tumor could reflect the growth characteristics manifest by histologic patterns of invasion and the microenvironment immune response and perhaps overall prognosis and response to therapy [16].…”

Section: Introductionmentioning

confidence: 99%

Histologic pattern of invasion and epithelial-mesenchymal phenotype predict prognosis in squamous carcinoma of the head and neck

et al. 2018

Self Cite

View full text Add to dashboard Cite

Introduction: Disruption of E-cadherin function and increased expression of vimentin and the transcriptional oncogene, SOX2, are thought to characterize epithelial to mesenchymal transition (EMT) in HNSCC that contributes to invasive and metastatic behavior. To determine if such changes relate to prognosis or host immune response, expression of these markers and correlations with clinical characteristics, histologic worst pattern of invasion (WPOI) and tumor infiltrating lymphocytes (TIL) and survival were assessed. Methods: Immunohistologic expression of markers was determined in tissue microarrays from 274 previously untreated HNSCC patients. Expression was correlated with levels of TILs in microcores and WPOI in biopsy specimens. Correlations were assessed by Kruskal-Wallis testing and Spearman correlation coefficients where appropriate. Overall and relapse-free survival were analyzed with Cox proportional hazards models. Median follow up was 60.0 months. Results: Loss of E-cadherin expression was significantly associated with low or absent SOX2 expression (R=0.433, p<0.0001). SOX2 expression and low grade WPOI were significantly associated with favorable overall (OS) and relapse free (RFS) survival in multivariable analysis. E-cadherin expression did not correlate with TILs, however WPOI score correlated indirectly with CD4, CD8, and FoxP3 levels. When grouped by primary treatment, lower grades (1,2) of WPOI predicted improved RFS and OS in patients treated with primary surgery but not for patients treated with chemoradiation. Conclusion: The findings suggest that SOX2 expression and WPOI are significant prognostic factors and that WPOI correlates with decreased T cell infiltration. The combination of markers and TILs might be useful in selecting patients for primary surgery.

show abstract

Section: Introductionmentioning

confidence: 99%

Histologic pattern of invasion and epithelial-mesenchymal phenotype predict prognosis in squamous carcinoma of the head and neck

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Conceitualmente as causas de recidiva locorregional nos tumores orais, foram revistas por Wolf (2012), que propugnou que a adequação da margem cirúrgica se relaciona muito mais com a resposta imune do hospedeiro e com a biologia molecular das células tumorais na frente invasora, do que com qualquer fator anatômico. Ademais, Milovancev & Russel (2017), corroborando com a proposição, aduziram que a recorrência, pode estar intrinsecamente relacionada aos conceitos de campo de cancerização, heterogeneidade intratumoral e microambiente tumoral.…”

Section: Introductionunclassified

Fibrosarcoma oral de bajo grado histológico y elevada agresividad biológica: reporte de un caso

Vasconcellos

2018

Pubvet

View full text Add to dashboard Cite

RESUMO.O objetivo deste relato foi descrever a ocorrência de um fibrossarcoma em uma cadela da raça Golden Retriever, com 12 anos de idade, pesando 42 kg. O animal apresentou histórico clínico de aumento do volume do plano nasal. Ao exame específico da cavidade oral, foi encontrada uma massa aderida à porção rostral do maxilar, encapsulada, medindo cerca de 5 cm de diâmetro, que se estendia cranialmente ao plano nasal, causando sua obstrução. Foi realizada biópsia incisional e o diagnóstico realizado com base na avaliação histopatológica. O animal foi submetido à quimioterapia neoadjuvante citorredutora e maxilectomia rostral bilateral. Até o momento não foi observada recidiva locorregional ou doença metastática. No Brasil, ainda são escassos os relatos de literatura envolvendo cirurgias radicais ou reconstrutivas em tumores oronasais. Palavras chave: cães, tumor, neoplasias da cavidade oralOral fibrosarcoma of low histological grade and high biological aggressiveness: case report ABSTRACT. The objective of this report was to describe the occurrence of a fibrosarcoma in a 12-year-old golden retriever, weighing 42 kg. The animal presented a clinical history of increased nasal plane volume. At the specific examination of the oral cavity, a mass adhered to the rostral portion of the maxilla was found, encapsulated, measuring about 5 cm in diameter, which extended cranially to the nasal plane, causing its obstruction. An incisional biopsy was performed and the diagnosis was made based on the histopathological evaluation. The animal was submitted to neoadjuvant chemoradiotherapy and bilateral rostral maxilectomy. To date no locoregional recurrence or metastatic disease has been observed. In Brazil, reports of literature involving radical or reconstructive surgeries in oronasal tumors are still scarce. Keywords: dogs, tumor, oral cavity neoplasiasFibrosarcoma oral de bajo grado histológico y elevada agresividad biológica: reporte de un caso RESUMEN. El objetivo de este relato fue describir el caso de un fibrosarcoma en una perra de raza Golden Retriever, con 12 años de edad, pesando 42 kg. El animal presentó un historial clínico de aumento del volumen del plano nasal. En el examen específico de la cavidad oral, se encontró una masa adherida a la porción rostral del maxilar, encapsulada, midiendo cerca de 5 cm de diámetro, que se extendía cranealmente al plano nasal, causando su obstrucción. Se realizó biopsia incisional y el diagnóstico realizado con base en la evaluación histopatológica. El animal fue sometido a quimioterapia citorreductora y

show abstract

“…Often, these recurrences and metastases are more resistant to traditional treatment modalities such as chemoradiation. Unfortunately, primary site recurrence occurs in 10-30% of all patients [6].…”

Section: Introductionmentioning

confidence: 99%

The Role of Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma and Its Clinical Implications

Karimnejad¹,

Lindquist²,

Lin³

2016

New Aspects in Molecular and Cellular Mechanisms of Human Carcinogenesis

View full text Add to dashboard Cite

Worldwide, more than , new cases of head and neck squamous cell carcinoma HNSCC are estimated to occur annually, making it the sixth most common human malignancy. Since their discovery in , cancer stem cells CSCs in HNSCC have garnered increased interest secondary to their properties of tumorigenicity, differenti-ation, proliferation, and self-renewal. CSCs are intrinsically more resistant to tradi-tional treatments such as radiation and chemotherapy, contributing to potential metastasis and recurrence of HNSCC. This chapter focuses first on normal head and neck stem cells, providing background for the discussion of a number of topics pertaining to the study of HNSCC CSCs including molecular biomarkers and clinical implications. Continued research to elucidate the properties of CSCs will undoubt-edly expand our knowledge surrounding the pathogenesis, metastasis, and relapse of HNSCC. Ultimately, a better understanding of CSC biomarkers, signaling pathways, and mechanisms of resistance will improve therapies and patient outcomes through targeted interventions.

show abstract

Surgical Margins in the Genomic Era

Cited by 14 publications

References 104 publications

Histologic pattern of invasion and epithelial-mesenchymal phenotype predict prognosis in squamous carcinoma of the head and neck

Histologic pattern of invasion and epithelial-mesenchymal phenotype predict prognosis in squamous carcinoma of the head and neck

Fibrosarcoma oral de bajo grado histológico y elevada agresividad biológica: reporte de un caso

The Role of Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma and Its Clinical Implications

Contact Info

Product

Resources

About