Prognostic significance of smoking and alcohol history in young age oral cavity cancer

Lee, Sung Uk; Moon, Sung Ho; Choi, Sung Rak; Cho, Kwan Ho; Park, Joo Yong; Jung, Y J; Ryu, Junsun; Ryu, Chang Hwan; Yun, Tak; Kim, Hyun Mi; Youn, Sang Hee; Oh, Eunseok

doi:10.1111/odi.13432

Cited by 14 publications

(14 citation statements)

References 37 publications

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“…Altogether, these findings support the hypothesis that the traditional risk factors can be responsible for just a small proportion of cases of oral cancer among young people and that factors other than tobacco and alcohol are implicated (Al‐Amad, Awad, & Nimri, 2014; Dalla Torre et al., 2018; Fan et al., 2014; Guidry, Birdwell, & Scott, 2018; Lee et al., 2020; Llewellyn, Linklater, Bell, Johnson, & Warnakulasuriya, 2003; Llewellyn, Bell, Johnson, & Warnakulasuriya, 2004; Purwanto et al., 2020; Toporcov et al., 2015; Vidal Loustau et al., 2019).…”

Section: Have You Ever Had a Diagnosis Of Genital Herpes? Have You Evsupporting

confidence: 67%

Oral Human Papillomavirus (HPV) and sexual behaviors in a young cohort of oral cancer survivors

et al. 2020

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Section: Have You Ever Had a Diagnosis Of Genital Herpes? Have You Evsupporting

confidence: 67%

Oral Human Papillomavirus (HPV) and sexual behaviors in a young cohort of oral cancer survivors

et al. 2020

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“…Eleven studies compared the treatment outcomes of OCSCC between SD and NSND groups 4,11,13,18,20,22,23,27,28,33,34 . Most patients were treated primarily via surgical intervention with or without adjunctive chemoradiation (Table 4).…”

Section: Resultsmentioning

confidence: 99%

“…Eleven studies compared the treatment outcomes of OCSCC between SD and NSND groups. 4,11,13,18,20,22,23,27,28,33,34 Most patients were treated primarily via surgical intervention with or without adjunctive chemoradiation (Table 4). Overall survival and recurrence-free survival assessed mostly among young OCSCC patients yielded no marked difference in the cumulative rates observed between NSND and SD groups.…”

Section: Treatment Outcomes and Tumor Prognosismentioning

confidence: 99%

“…13,21,23,27 However, two reports from China or Chinese territories observed better overall survival for NSND than SD patients while others from South Korea and Israel only suggested from subgroup analyses that young NSND patients had poorer overall survival compared to young SD patients. 11,13,18,28 Therefore, the disparity in the overall survival between these two patient groups especially for young patients with oral cavity cancer remains very controversial.…”

Section: Treatment Outcomes and Tumor Prognosismentioning

confidence: 99%

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“Fact or fiction?”: Oral cavity cancer in nonsmoking, nonalcohol drinking patients as a distinct entity—Scoping review

Adeoye

Tan

et al. 2021

Head & Neck

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Oral cavity cancer is often described as a lifestyle‐related malignancy due to its strong associations with habitual factors, including tobacco use, heavy alcohol consumption, and betel nut chewing. However, patients with no genetically predisposing conditions who do not indulge in these risk habits are still being encountered, albeit less commonly. The aim of this review is to summarize contemporaneous reports on these nonsmoking, nonalcohol drinking (NSND) patients. We performed database searching to identify relevant studies from January 1, 2000 to March 31, 2021. Twenty‐six articles from 20 studies were included in this study. We found that these individuals were mostly females in their eighth decade with tumors involving the tongue and gingivobuccal mucosa. This review also observed that these patients were likely diagnosed with early stage tumors with overexpression of programmed death‐ligand 1 (PD‐L1) and increased intensity of tumor infiltrating lymphocytes. Treatment response and disease‐specific prognosis were largely comparable between NSND and smoking/drinking patients.

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“…The malignant transformation rate of OL is higher in non-smokers than in smokers [11][12][13][14][15]. However, although some recent reports [16,17] have shown that non-smokers with OSCC may have a worse prognosis, HNSCC is traditionally associated with better overall survival in non-smokers [18]. Non-smoking HNSCC patients had a significantly greater proportion of programmed death-ligand 1 (PD-L1)-positive cells in the microenvironment of HNSCC and had a higher response rate to anti-programmed death 1 (PD-1) checkpoint inhibitors than smoking HNSCC patients [19,20].…”

Section: Introductionmentioning

confidence: 99%

Effect of smoking status and programmed death-ligand 1 expression on the microenvironment and malignant transformation of oral leukoplakia: A retrospective cohort study

et al. 2021

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Tobacco smoking is associated with an increased risk of oral leukoplakia and head and neck cancer. Although it has recently been reported that the establishment of an immunosuppressive microenvironment in oral potentially malignant disorders may lead to malignant transformation, it is unclear whether the microenvironments of oral potentially malignant disorders differ according to smoking status. We examined differences in programmed death-ligand 1 (PD-L1) expression and subepithelial CD163+ TAM and CD8+ cell/lymphocyte counts in the microenvironment of oral leukoplakia of smoking and non-smoking patients and investigated their associations with malignant transformation. Pathology reports and original biopsy request forms from 1995–2015 were retrospectively reviewed. Lesions clinically characterized as white plaques/lesions of the oral mucosa and pathologically diagnosed as oral epithelial dysplasia were included. Immunohistochemistry was performed to evaluate PD-L1 expression and subepithelial CD163+/CD8+ cell counts. The significance of prognostic factors in predicting malignant transformation was determined using Cox regression analysis. Statistical significance was defined as P<0.05. In total, 200 patients with oral leukoplakia were selected. The mean age at diagnosis was higher in non-smoking patients (n = 141; 66.9 years) than in smoking patients (n = 59; 60.5 years). The 5-year cumulative malignant transformation rate was higher in non-smoking patients than in smoking patients (9.3% vs. 3.0%, respectively). Oral leukoplakia was associated with significantly higher PD-L1 expression and increased numbers of subepithelial CD163+ cells in the non-smoking group compared with the smoking group. Non-smoking-related oral leukoplakia with positive PD-L1 expression was associated with a 6.97-fold (95% confidence interval: 2.14–22.7) increased risk of malignant transformation. The microenvironment of oral leukoplakia differed according to smoking status. A combination of smoking status and PD-L1 expression may predict malignant transformation in oral leukoplakia patients. This study highlights the importance of understanding the interaction between smoking and the microenvironment in oral leukoplakia.

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Prognostic significance of smoking and alcohol history in young age oral cavity cancer

Cited by 14 publications

References 37 publications

Oral Human Papillomavirus (HPV) and sexual behaviors in a young cohort of oral cancer survivors

Oral Human Papillomavirus (HPV) and sexual behaviors in a young cohort of oral cancer survivors

“Fact or fiction?”: Oral cavity cancer in nonsmoking, nonalcohol drinking patients as a distinct entity—Scoping review

Effect of smoking status and programmed death-ligand 1 expression on the microenvironment and malignant transformation of oral leukoplakia: A retrospective cohort study

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