Prognostic significance of radiologically determined neck node volume in head and neck cancer: A systematic review

Lodder, Wouter L.; Pameijer, Frank A.; Rasch, Coen R. N.; Brekel, M.W.M. van den; Balm, Alfons J. M.

doi:10.1016/j.oraloncology.2011.11.001

Cited by 25 publications

(21 citation statements)

References 34 publications

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“…Schwartz et al, 16 using the data of Radiation Therapy Oncology Group 0522, analyzed the effectiveness of nodal MTV in patients with head and neck cancer and showed that nodal MTV had no prognostic significance. Conversely, in a systematic review of patients with head and neck tumors treated with CCRT or RT, Lodder et al 29 noted the prognostic significance of node volume, which may confirm the usefulness of MTV-N. From the results of the present study, it can be thought that MTV-T is an essential predictor for patients with large MTV-T, and MTV-N is not as important. Conversely, for patients with small MTV-T, MTV-N is a meaningful predictor, and MTV-T is not as important.…”

Section: Discussionsupporting

confidence: 61%

Prognostic significance of pretreatment 18F‐fluorodeoxyglucose positron emission tomography evaluation using metabolic tumor volume of the primary tumor and lymph nodes in advanced hypopharyngeal cancer

et al. 2018

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Background The purpose of this study was to retrospectively evaluate the usefulness of pretreatment positron emission tomography (PET) using metabolic tumor volume (MTV) of the primary tumor and lymph nodes in advanced hypopharyngeal cancer. Methods From June 2007 to December 2015, consecutive patients with advanced hypopharyngeal cancer who underwent PET and were treated with definitive radiation therapy were retrospectively reviewed. Results A total of 61 patients were eligible for this study. On multivariate analysis, MTV of the primary tumor (MTV‐T) was significantly related to the local control rate and overall survival (OS) (P = .036 and .012, respectively). In patients with lower MTV‐T, MTV of metastatic lymph nodes (MTV‐N) was significantly related to disease‐specific survival and OS (P = .012 and .017, respectively). Conclusion MTV‐T is a significant predictor in patients with advanced hypopharyngeal cancer, and MTV‐N is also significant in patients with lower MTV‐T.

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Section: Discussionsupporting

confidence: 61%

Prognostic significance of pretreatment 18F‐fluorodeoxyglucose positron emission tomography evaluation using metabolic tumor volume of the primary tumor and lymph nodes in advanced hypopharyngeal cancer

et al. 2018

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“…Metabolic tumor volume is a novel PET-specific measure, which incorporates complementary information relevant to both disease burden (akin to clinical stage and CT-derived tumor volume, which are prognostic for outcomes (25, 26)) and tumor metabolic activity. Although the size of our dataset is limited, our findings add to an emerging literature, which suggests that high primary metabolic tumor volume is associated with local-regional relapse and reduced progression-free survival following radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Tumor Volume as a Prognostic Imaging-Based Biomarker for Head-and-Neck Cancer: Pilot Results From Radiation Therapy Oncology Group Protocol 0522

Schwartz

Harris

Yao

et al. 2015

International Journal of Radiation Oncology*Biology*Physics

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Purpose To evaluate candidate FDG-PET/CT imaging biomarkers for head and neck chemoradiotherapy outcomes in the cooperative group trial setting. Methods RTOG 0522 patients consenting to a secondary FDG-PET/CT sub-study were serially imaged at baseline and 8 weeks following radiation. Maximum standardized uptake value (SUVmax), SUV peak (mean SUV within a 1 cm sphere centered on SUVmax), and metabolic tumor volume (MTV) using 40% of SUVmax as threshold were obtained from primary tumor and involved nodes. Results Out of 940 patients entered onto RTOG 0522, 74 were analyzable for this sub-study. Neither high baseline SUVmax nor SUVpeak from primary or nodal disease were associated with poor treatment outcomes. However, primary tumor MTV above the cohort median was associated with worse LRC (HR 4.01, 95% CI [1.28, 12.52], p = 0.02) and PFS (HR 2.34, 95% CI [1.02, 5.37], p = 0.05). Although MTV and T stage appeared to correlate (mean MTV 6.4, 13.2, 26.8 for T2, T3, and T4 tumors, respectively), MTV remained a strong independent prognostic factor for PFS in bivariate analysis that included T stage. Primary MTV remained prognostic in p16-associated oropharyngeal cancer cases, although sample size was limited. Conclusion High baseline primary tumor MTV was associated with worse treatment outcomes in this limited patient subset of RTOG 0522. Additional confirmatory work will be required to validate primary tumor MTV as a prognostic imaging biomarker for patient stratification in future trials.

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“…Until today, however, tumour volumes are not regularly determined, probably as the current methods are time‐consuming. It seems therefore preferable to develop an (semi‐)automated reproducible method for the tumour volume measurements of both the primary and nodal tumour volume …”

Section: Introductionmentioning

confidence: 99%

Semi‐automatic tumour volume measurements on MR‐Imaging using smartbrush^® in oropharyngeal carcinomas; our experience in 5 patients

Lodder

Dorgelo

Lancaster

et al. 2018

Clinical Otolaryngology

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Prognostic significance of radiologically determined neck node volume in head and neck cancer: A systematic review

Cited by 25 publications

References 34 publications

Prognostic significance of pretreatment 18F‐fluorodeoxyglucose positron emission tomography evaluation using metabolic tumor volume of the primary tumor and lymph nodes in advanced hypopharyngeal cancer

Prognostic significance of pretreatment 18F‐fluorodeoxyglucose positron emission tomography evaluation using metabolic tumor volume of the primary tumor and lymph nodes in advanced hypopharyngeal cancer

Metabolic Tumor Volume as a Prognostic Imaging-Based Biomarker for Head-and-Neck Cancer: Pilot Results From Radiation Therapy Oncology Group Protocol 0522

Semi‐automatic tumour volume measurements on MR‐Imaging using smartbrush^® in oropharyngeal carcinomas; our experience in 5 patients

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Prognostic significance of radiologically determined neck node volume in head and neck cancer: A systematic review

Cited by 25 publications

References 34 publications

Prognostic significance of pretreatment 18F‐fluorodeoxyglucose positron emission tomography evaluation using metabolic tumor volume of the primary tumor and lymph nodes in advanced hypopharyngeal cancer

Prognostic significance of pretreatment 18F‐fluorodeoxyglucose positron emission tomography evaluation using metabolic tumor volume of the primary tumor and lymph nodes in advanced hypopharyngeal cancer

Metabolic Tumor Volume as a Prognostic Imaging-Based Biomarker for Head-and-Neck Cancer: Pilot Results From Radiation Therapy Oncology Group Protocol 0522

Semi‐automatic tumour volume measurements on MR‐Imaging using smartbrush® in oropharyngeal carcinomas; our experience in 5 patients

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Semi‐automatic tumour volume measurements on MR‐Imaging using smartbrush^® in oropharyngeal carcinomas; our experience in 5 patients