Prognostic significance of pretreatment 18F‐fluorodeoxyglucose positron emission tomography evaluation using metabolic tumor volume of the primary tumor and lymph nodes in advanced hypopharyngeal cancer

Abstract

Background The purpose of this study was to retrospectively evaluate the usefulness of pretreatment positron emission tomography (PET) using metabolic tumor volume (MTV) of the primary tumor and lymph nodes in advanced hypopharyngeal cancer. Methods From June 2007 to December 2015, consecutive patients with advanced hypopharyngeal cancer who underwent PET and were treated with definitive radiation therapy were retrospectively reviewed. Results A total of 61 patients were eligible for this study. On multivariate analysis, MTV of the primary tumor (MTV‐T) was significantly related to the local control rate and overall survival (OS) (P = .036 and .012, respectively). In patients with lower MTV‐T, MTV of metastatic lymph nodes (MTV‐N) was significantly related to disease‐specific survival and OS (P = .012 and .017, respectively). Conclusion MTV‐T is a significant predictor in patients with advanced hypopharyngeal cancer, and MTV‐N is also significant in patients with lower MTV‐T.

Utility and limitations of metabolic parameters in head and neck cancer: finding a practical segmentation method

“…In the literature, besides Castelli et al [ 32 ] and this study, most papers do not find a statistical association between LNM and survival in HNSCC [ 33 – 40 ], although it may play a role in patients with HPV + oropharyngeal cancer [ 41 – 44 ] and in hypopharyngeal patients with a low MTV [ 35 ]. Hoshikawa et al [ 45 ] share the same findings we obtained in our BLT tumor TLG models, where statistical significance was achieved only after the addition of the LNM.…”

Nodal tumor volume as a prognostic factor for head and neck squamous cell carcinoma: a systematic review

“…Interestingly, the low volumetric cutoff of 11.3 mL, in a study be Fujii and colleagues [20] regarding hypopharyngeal SCC, concerned those patients treated surgically with total laryngectomy and neck dissection. On the other hand, the considerably high volumetric cutoff of 73.5 mL in the study by Okazaki and coworkers [22] concerned patients with low volume (MTV-T <19.9) primary hypopharyngeal tumor treated with definitive radiotherapy +/-chemotherapy. In line with the aforementioned observation the lowest proposed volumetric cutoff in the oropharyngeal SCC studies, according to Kim et al [26], where HPV (+) patients with OPC were again treated surgically with curative resection followed by postoperative radiotherapy or chemoradiotherapy.…”

Prognostic Value of 18F-Fluorodeoxyglucose–Positron Emission Tomography/Magnetic Resonance Imaging in Patients With Hypopharyngeal Squamous Cell Carcinoma

“…Although SUV max may not be representative of the total tumor uptake for the entire tumor, volume-based parameters, such as MTV and TLG, may represent the total volume and total activity of the metabolically active tumor cells. Recent studies have demonstrated the ability of MTV to predict DFS in patients with head and neck cancer 43,44 . Seol et al 31 found that high MTV, but not SUV max , was associated with poor PFS and OS in 59 patients with advanced head and neck cancer.…”