Prognostic significance of pretreatment albumin/globulin ratio in patients with hepatocellular carcinoma

Deng, Yan; Pang, Qing; Miao, Runchen; Chen, Wei; Zhou, Yanyan; Bi, Jianbin; Liu, Sushun; Zhang, Jingyao; Qu, Kai; Liu, Chang

doi:10.2147/ott.s109736

Cited by 64 publications

(51 citation statements)

References 54 publications

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“…The albumin/ globulin ratio (AGR) can be calculated by measuring the total serum protein and albumin concentrations. The AGR can be used for prognostic evaluation of tumors (4,5). Although serum albumin and globulin were thought to correlate with AECOPD progression, few reports have described the application of the AGR to AECOPD (3,6).…”

Section: Original Articlementioning

confidence: 99%

Application of albumin/globulin ratio in elderly patients with acute exacerbation of chronic obstructive pulmonary disease

Qin¹,

Qin²,

Wu³

et al. 2018

J. Thorac. Dis.

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Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) has become an important disease of hospitalized elderly patients, which lack simple and inexpensive indicators for evaluating the condition and prognosis. This study was performed to investigate the clinical significance of the serum albumin/globulin ratio (AGR) in elderly patients with AECOPD.Methods: The data of 252 hospitalized elderly patients with AECOPD, 89 stable COPD patients and 115 elderly healthy individuals were analyzed and compared. The differences in the AGR, logarithm of the serum C-reactive protein (LogCRP) level, prealbumin (PA) level, and immunoglobulin G (IgG) level were compared. AECOPD patients were grouped using the optimal cutoff values of each index to compare the difference in the combined infection rate. The correlation between hospital stays and AGR was analyzed. Results: The AGR, LogCRP, PA level, and IgG level were different among the AECOPD group, stable COPD group and healthy control groups (P<0.05). The AGR, LogCRP, and PA level were different (P<0.05) among the Global Initiative for Chronic Obstructive Lung Disease (GOLD) I, II, II, and IV groups. Age, AGR, LogCRP, and PA level were different (P<0.05) between the infection and non-infection groups. After grouping according to the optimal cutoff values, the combined infection rate was different (P<0.05). The AGR was negatively correlated with the hospital stay (r=−0.583, P<0.001). The hospital stay was longer in patients with an AGR of <1.37 than ≥1.37 (P<0.001). Conclusions: The AGR can be regarded as a reference index for evaluating the condition of elderly patients with AECOPD, determining the presence of combined infection, and predicting the prognosis. Keywords: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD); combined infection; albumin/globulin ratio (AGR); C-reactive protein (CRP); prealbumin (PA) Qin et al. The role of serum AGR in AECOPD J Thorac Dis 2018;10(8):4923-4930 jtd.amegroups.com Qin et al. The role of serum AGR in AECOPD Comparison of each index between AECOPD patients with and without infection

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Section: Original Articlementioning

confidence: 99%

Application of albumin/globulin ratio in elderly patients with acute exacerbation of chronic obstructive pulmonary disease

Qin¹,

Qin²,

Wu³

et al. 2018

J. Thorac. Dis.

View full text Add to dashboard Cite

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“…Numerous factors have been identified as prognostic indicators and are incorporated into various staging systems. These factors include lesion numbers, vascular invasion, portal hypertension, regional lymph node metastases, distant metastases, laboratory examination indicators such as serum albumin and bilirubin, and so on. Tumor size has been included in several staging systems, such as the Liver Cancer Study Group of Japan TNM staging system and the Hong Kong staging system .…”

Section: Introductionmentioning

confidence: 99%

The power of tumor sizes in predicting the survival of solitary hepatocellular carcinoma patients

et al. 2018

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BackgroundVascular invasion, rather than tumor size, was applied into the 7th edition of the AJCC TNM staging system to predict survival of solitary hepatocellular carcinoma (HCC) patients. However, does this mean tumor size is of little value in prognostic prediction? The current study was designed to explore the prognostic ability of tumor sizes in solitary HCC.MethodsA total of 18 591 patients with solitary HCC categorized as T1 and T2 were retrieved from the Surveillance Epidemiology and End Results (SEER) database. The Cox proportional hazards regression model was adopted to evaluate the impact of tumor sizes on overall survival (OS) and disease‐specific survival (DSS) in general and in subgroups stratified by vascular invasion and surgery type.ResultsLarge tumor sizes (>39 mm) were associated with unfavorable clinicopathologic characteristics. Compared with tumors ≤30 mm, tumors between 31‐50 mm and tumors >50 mm showed significantly worse OS and DSS in general using multivariate analysis (all P < 0.001). In subgroup analyses, for patients without vascular invasion, tumor size was a notable prognostic indicator for OS in the radiofrequency ablation group (P < 0.001), rather than in the liver resection or transplantation group. Nevertheless, for patients with vascular invasion, tumor sizes exhibited a notable impact on OS in the liver resection and transplantation group.ConclusionsThe AJCC TNM staging system for solitary HCC would be more comprehensive if tumor sizes were integrated into the T2 classification. Additionally, for T1 patients, tumor sizes play no role in the choice between resection and transplantation.

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“…The association of AGR and mortality had been reported by previous studies on varied populations, including non-ST elevation myocardial infarction [19], colorectal cancer [20,21], hepatocellular carcinoma [22], and early-stage non-small cell lung cancer [23]. Suh et al reported low AGR was a risk factor for cancer incidence and mortality, both in the short-and long terms, in 26,974 healthy patients [24].…”

Section: Discussionmentioning

confidence: 76%

Albumin-globulin ratio and mortality in patients on peritoneal dialysis: a retrospective study

et al. 2020

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Background: Albumin-globulin ratio (AGR), a variable based on serum albumin and non-albumin proteins, has been demonstrated as a predictor of mortality in patients with malignant neoplasm. The aim of this study was to evaluate the prognostic value of AGR on peritoneal dialysis (PD) patients. Methods: We retrospectively analyzed 602 incident PD patients from January 1st, 2008, to December 31st, 2017, at our center and followed them until December 31st, 2018. Kaplan-Meier curves and multivariate Cox regression models were applied to analyze the association between AGR and all-cause of mortality and cardiovascular mortality. Results: The median follow-up time was 32.17 (interquartile range = 32.80) months. During follow-up, 131 (21.8%) patients died, including 57 patients (43.5%) who died due to cardiovascular diseases. Kaplan-Meier curves showed that patients with AGR > 1.26 had better rates of survival than those with AGR ≤ 1.25 (p < 0.001). After adjusting for potential confounders, the lower AGR level was significantly associated with an increased all-cause and cardiovascular mortality [hazard ratio (HR): 1.57, 95% confidence interval (CI): 1.07-2.32, p = 0.022 and HR: 2.01, 95% CI: 1.10-3.69, p = 0.023 respectively]. Conclusions: Patients with a low AGR level had an increased all-cause and cardiovascular mortality. AGR may be a useful index in identifying patients on PD at risk for CVD and all-cause of mortality.

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Prognostic significance of pretreatment albumin/globulin ratio in patients with hepatocellular carcinoma

Cited by 64 publications

References 54 publications

Application of albumin/globulin ratio in elderly patients with acute exacerbation of chronic obstructive pulmonary disease

Application of albumin/globulin ratio in elderly patients with acute exacerbation of chronic obstructive pulmonary disease

The power of tumor sizes in predicting the survival of solitary hepatocellular carcinoma patients

Albumin-globulin ratio and mortality in patients on peritoneal dialysis: a retrospective study

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