Prognostic significance of preoperative serum Krebs von den Lungen-6 level in non-small cell lung cancer

Tomita, Masaki; Ayabe, Takanori; Chosa, Eiichi; Nose, Naohiro; Nakamura, Kunihide

doi:10.1007/s11748-016-0706-4

Cited by 12 publications

(14 citation statements)

References 18 publications

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“…Our previous study also showed the similar findings [9], but the number of patient with IP was very small (only 14 patients).…”

Section: Introductionsupporting

confidence: 77%

“…Therefore, serum KL-6 level can be used to monitor activity of IP. In addition, previous studies showed that serum KL-6 level is an independent prognostic factor in NSCLC patients [6] [7] [8] [9]. The reason why serum KL-6 level can serve as a prognostic biomarker in NSCLC patients who undergo curative surgery has been unknown in detail.…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, only a few study examined the prognostic significance of serum KL-6 level in NSCLC patients with IP [8] [9]. Miyazaki et al [8] reported the prognostic significance of serum KL-6 levels in lung cancer patients with or without IP.…”

Section: Introductionmentioning

confidence: 99%

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Preoperative Serum Krebs Von Den Lungen-6 and Surfactant Protein-D Levels in Non-Small Cell Lung Cancer Patients with Interstitial Pneumonia

Tomita¹,

Ayabe²,

Chosa³

et al. 2017

OJTS

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We retrospectively analyzed the prognostic significance of preoperative serum Krebs von den Lungen-6 (KL-6) surfactant protein-D (SP-D) levels in non-small cell lung cancer (NSCLC) patients with interstitial pneumonia (IP). We enrolled 41 NSCLC patients with IP who have undergone curative surgery. Prognostic significance of serum KL-6 and SP-D levels was examined. We found a significant relationship between serum KL-6 and SP-D levels in NSCLC patients with IP. However, the 5-year survival of patients with high serum KL-6 level was poor, whereas serum SP-D level was not related to patients' survival. Univariate analysis revealed that there was a trend towards an association between serum KL-6 level and patients' prognosis but this did not reach statistical significance. This might be due to small number of study patients. In conclusion, there is a possibility that serum KL-6 level is a prognostic marker regardless of the presence of IP.

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“…Our previous study also showed the similar findings [9], but the number of patient with IP was very small (only 14 patients).…”

Section: Introductionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

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Preoperative Serum Krebs Von Den Lungen-6 and Surfactant Protein-D Levels in Non-Small Cell Lung Cancer Patients with Interstitial Pneumonia

Tomita¹,

Ayabe²,

Chosa³

et al. 2017

OJTS

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“…Eight studies examined the relevance between MUC1 expression and the clinical features of NSCLC [ 16 – 19 , 21 , 22 , 24 , 27 ]. Pooled data revealed that elevated MUC1 expression was significantly related to performance status (≥ 2 vs. < 2; OR = 2.32, 95% CI: 1.13–4.73, P = 0.021).…”

Section: Resultsmentioning

confidence: 99%

MUC1 overexpression predicts worse survival in patients with non-small cell lung cancer: evidence from an updated meta-analysis

et al. 2017

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BackgroundPrevious studies on the prognostic role of MUC1 expression in non-small cell lung cancer (NSCLC) remain controversial. We conducted a meta-analysis to appraise the clinicopathological and prognostic effect of MUC1 in NSCLC patients.Materials and MethodsSearches of PubMed, EMBASE and CNKI (Chinese National Knowledge Infrastructure) were conducted and relevant studies were extracted. The pooled hazard ratio (HR) or odds ratio (OR) with 95% confidence intervals (CIs) were used to estimate effects. Heterogeneity among studies and publication bias were also evaluated.ResultsA total of 15 studies with 1,682 patients were included in this meta-analysis. The pooled HRs indicated that elevated MUC1 expression was associated with poorer overall survival (HR = 2.12, 95% CI: 1.47–3.05; P < 0.001) and progression-free survival (HR = 2.00, 95% CI: 1.53-2.62; P < 0.001) in patients with NSCLC. Significant associations were also found in patients treated with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) (HR = 3.16, 95% CI: 2.21–4.52, P < 0.001) and with a platinum-based regimen (HR = 4.35, 95% CI: 2.45–7.72, P < 0.001). Additionally, MUC1 overexpression was significantly associated with performance status (OR = 2.32, 95% CI: 1.13–4.73, P = 0.021).ConclusionsMUC1 could be a valuable biomarker of the prognoses of NSCLC patients.

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“…Высокие уровни ýтого маркера в сыворотке не всегда обусловлены злокачественным потенциалом опухоли. Уровень РЭА увеличивается с возрастом, что отмечается при многих неопухолевых заболеваниях, в частности при воспалительных заболеваниях кишечника, хроническом гепатите, каротидном атеросклерозе, метаболическом синдроме, а также при курении [18]. Поскольку ýто создает серьезный клинический барьер в гетерогенных выборках, связанный с наличием как неопластических, так и неопухолевых процессов, определение РЭА с использованием известных пороговых значений применяется для мониторинга рецидивов злокачественных опухолей и развития метастазов у больных, получающих неоадъювантную терапию [19].…”

Section: Introductionunclassified

The effect of canceroembryonic antigen on cytokine production by immunocompetent blood cells in patients with breast cancer

et al. 2018

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Aim. Investigation of the influence of canceroembryonic antigen (CEA) on the immune cells in patients with breast tumors.Materials and methods. Peripheral blood of 67 patients with invasive ductal carcinoma (n = 44), fibroadenoma (n = 12) and breast pre-cancer (n = 11). In the supernatants of the blood cells cytokine production induced by CEA was determined by ELISA.Results. It was found that CEA stimulated production of IL-6, IL-8, IL-10, IL-1β, IL-1Ra, TNFα, G-CSF, GM-CSF and the protein MCP-1 by blood immune cells in patients with fibroadenoma compared with groups of patients with invasive ductal carcinoma and precancerous lesions. Stimulation index of CEA on cytokine production by immunocompetent cells in patients in these groups was lower than in groups of patients with fibroadenoma due to initially high levels of spontaneous cytokine production.Results. In patients with fibroadenoma CEA was found to stimulate the production of IL-6, IL-8, IL-10, IL-1β, IL-1Ra, TNFa, G-CSF, GM-CSF and MCP-1 compared with groups of patients with invasive ductal carcinoma and precancerous conditions. Indexes of the influence of CEA on cytokine production by immunocompetent cells in these groups was lower than in the fibroadenoma due to initially high spontaneous production of cytokines.Conclusion. Evident spontaneous cytokine-producing function of immunocompetent blood cells was revealed in patients with invasive ductal carcinoma and precancerous conditions compared to patients with fibroadenoma. The differences between the indices of CEA influence on cytokine production in patients with malignant, benign and precancerous conditions can serve as a basis for the development of methods of differential diagnosis of breast tumors.

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Prognostic significance of preoperative serum Krebs von den Lungen-6 level in non-small cell lung cancer

Abstract: Serum KL-6 level is a prognostic factor for resected NSCLC patients, especially patients without ILD. There is a possibility that serum KL-6 level is a prognostic marker regardless of the presence of ILD.

Cited by 12 publications

References 18 publications

Preoperative Serum Krebs Von Den Lungen-6 and Surfactant Protein-D Levels in Non-Small Cell Lung Cancer Patients with Interstitial Pneumonia

Preoperative Serum Krebs Von Den Lungen-6 and Surfactant Protein-D Levels in Non-Small Cell Lung Cancer Patients with Interstitial Pneumonia

MUC1 overexpression predicts worse survival in patients with non-small cell lung cancer: evidence from an updated meta-analysis

The effect of canceroembryonic antigen on cytokine production by immunocompetent blood cells in patients with breast cancer

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