Prognostic significance of preoperative neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in patients with gallbladder carcinoma

Elevated pre-operative inflammatory markers are inversely related to survival outcomes. They are relatively inexpensive, easy measurable parameters that could aid in the decision making process involved in the management of GBC. Sub-stratification of groups utilizing inflammatory markers may help guide surgical strategy. However, these studies are retrospective and of low to moderate quality. High quality, prospective studies with well-defined inclusion criteria and outcomes are needed to guide the role of inflammatory markers in the management of GBC.

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“…Zhang et al . used receiver operating characteristic curves (ROC) to determine the NLR cut‐off . Ong et al .…”

Section: Resultsmentioning

confidence: 99%

Prognostic significance of pre‐operative inflammatory markers in resected gallbladder cancer: a systematic review

Saqib

Pathak

Smart

et al. 2017

ANZ Journal of Surgery

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“…Similar results have also been reported in other cancers (28,30) where male patients and patients with more advanced TNM stages were associated with a higher risk of cancer-specific mortality. Furthermore, tumor grade, which is also an inherent characteristic of tumors and has been shown in many previous studies (31,32) to be an independent prognostic factor in patients with GBC, was considered when the prognosis was evaluated in patients with GBC after surgery in the present study. The inclusion of the additional variables in the nomograms led to increased accuracy in survival prediction using nomograms compared with the 8th edition TNM staging system.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Model to Predict Cancer-Specific Survival for Patients With Gallbladder Carcinoma After Surgery: A Population-Based Analysis

Cai

Zhang

et al. 2019

Front. Oncol.

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Predicting the prognosis of gallbladder carcinoma (GBC) has always been important for improving survival. The objective of this study was to determine the risk factors of survival for patients with GBC after surgery and to develop predictive nomograms for overall survival (OS) and cancer-specific survival (CSS) using a large population-based cohort. We identified 2,762 patients with primary resectable GBC in the Surveillance, Epidemiology, and End Results (SEER) database for the period of 2004 to 2014 and another 152 patients with GBC after surgery from Sun Yat-sen University Cancer Center (SYSUCC) for the period of 1997 to 2017. The 1-, 2-, and 3-year cancer-specific mortalities were 37.2, 52.9, and 59.9%, while the competing mortalities were 5.8, 7.8, and 9.0%, respectively. Nomograms were developed to estimate OS and CSS, and these were validated by concordance indexes (C-indexes) and evaluated using receiver operating characteristic (ROC) curves. The C-indexes of the nomograms for OS and CSS prediction were 0.704 and 0.732, respectively. In addition, compared with the 8th Tumor-Node-Metastasis staging system, the newly established nomograms displayed higher areas under the ROC curves for OS and PFS prediction. The nomograms are well-validated and could thus aid individual clinical practice.

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“…12 Our previous study showed that preoperative NLR and PLR were prognostic factors for gallbladder carcinoma. 13 And we also demonstrated the prognostic value of NLR for renal cell carcinoma, which was affected by hypertension. 14 Until most recently, the studies of the prognostic values of NLR and PLR in head and neck cancer or oral cancer have just emerged, however, are quite limited and conflicting.…”

Section: Introductionmentioning

confidence: 62%

“…Preoperative platelet lymphocyte ratio (PLR) has also been reported to predict for the survival of the patients with gastric cancer, colorectal cancer, hepatocellular carcinoma, ovarian cancer, and non‐small cell lung cancer . Our previous study showed that preoperative NLR and PLR were prognostic factors for gallbladder carcinoma . And we also demonstrated the prognostic value of NLR for renal cell carcinoma, which was affected by hypertension .…”

Section: Introductionmentioning

confidence: 82%

Preoperative neutrophil lymphocyte ratio but not platelet lymphocyte ratio predicts survival and early relapse in patients with oral, pharyngeal, and lip cancer

Wang

et al. 2019

Head & Neck

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Background To evaluate the prognostic value of preoperative neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) in oral, pharyngeal, and lip cancer for survival and relapse. Methods Clinic‐pathologic and hematological records were retrospectively retrieved. Patients completed follow‐up period were included for survival and relapse analysis. Results The preoperative NLR value was a prognostic factor for both overall survival and relapse‐free survival. The high NLR group demonstrated higher total relapse rate, higher local relapse rate, and higher relapse rate within 12 months. However, the preoperative PLR did not associate with survival or relapse. Conclusions The preoperative NLR, not PLR, is an independent prognostic indicator of survival. It also exhibits predictive value for relapse, particularly early relapse within 12 months. The preoperative NLR value might be recommended as a useful tool for predicting the outcomes and stratifying patients for different management strategies.

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Prognostic significance of preoperative neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in patients with gallbladder carcinoma

Abstract: Preoperative NLR and PLR were closely related to prognosis of patients with GBC and might be useful for the evaluation of prognosis of patients with GBC.

Cited by 51 publications

References 29 publications

Prognostic significance of pre‐operative inflammatory markers in resected gallbladder cancer: a systematic review

Prognostic significance of pre‐operative inflammatory markers in resected gallbladder cancer: a systematic review

Prognostic Model to Predict Cancer-Specific Survival for Patients With Gallbladder Carcinoma After Surgery: A Population-Based Analysis

Preoperative neutrophil lymphocyte ratio but not platelet lymphocyte ratio predicts survival and early relapse in patients with oral, pharyngeal, and lip cancer

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