Prognostic significance of preoperative inflammatory response biomarkers in patients undergoing curative thoracoscopic esophagectomy for esophageal squamous cell carcinoma

Hirahara, Noriyuki; Matsubara, Takeshi; Kawahara, Daisuke; Nakada, Soichi; Ishibashi, Shuichi; Tajima, Yoshitsugu

doi:10.1016/j.ejso.2016.11.018

Cited by 36 publications

(26 citation statements)

References 22 publications

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“…Recent studies have shown that a high PLR might be associated with poor prognosis of esophageal cancer (13,14). However, this result was not confirmed in other studies (15,16). In addition, several inflammatory factors may affect tumor characteristics, such as tumor length and depth of tumor invasion.…”

Section: Original Articlementioning

confidence: 86%

“…We then reviewed the remaining 25 studies and excluded 12 studies for the following reasons: two studies used data with a continuous PLR level for survival analysis, without a clear cutoff value; one study performed the analysis in the samples with a repeated population; four studies did not use OS as an endpoint; two studies did not describe the relationship between PLR and OS; and three studies did not report the HR value. A final 13 studies were included in the meta-analysis, with 4,621 patients ( Figure 1) (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25). These studies were published from 2013 to 2017.…”

Section: Study Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic and clinicopathological significance of platelet to lymphocyte ratio in esophageal cancer: a meta-analysis

Deng¹,

Zhang²,

Sun³

et al. 2018

J. Thorac. Dis.

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Section: Original Articlementioning

confidence: 86%

Section: Study Characteristicsmentioning

confidence: 99%

Prognostic and clinicopathological significance of platelet to lymphocyte ratio in esophageal cancer: a meta-analysis

Deng¹,

Zhang²,

Sun³

et al. 2018

J. Thorac. Dis.

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“…In case of disturbance from the proportions of TG, HDL-c and LDL-c, we included them as confounding factors to avoid interference from them. The reliability of CONUT score was estimated superior than SII which only included indexes re ecting in ammatory response 37,38 in some kinds of carcinoma, but there have been no evidence to prove the advantages of CONUT scores compared with other in ammatory indicators. The prognostic value of CONUT score has been demonstrated in soft-tissue sarcoma 39,40 that the raised score of CONUT indeed improved risk of death.…”

Section: Discussionmentioning

confidence: 90%

Prognostic Value of Various Nutritional Assessment Indicators on Long Term and Short Term Outcomes for Patients with High Grade Osteosarcoma Receiving Surgical Resection

Yang

Ding

2020

Preprint

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Background: Many researchers have focused on exploring the association between patients’ nutritional status and clinical outcomes with some easy-to-reach indicators, especially in some carcinoma with high incidence. However, there was little attention on sarcomas and the objective of this study was to evaluate the prognostic value of some innovative nutrition associated indexes on patients with high grade osteosarcoma receiving surgical excision. Method: We retrospectively included patients’ clinical characteristics diagnosed as high grade osteosarcomas histologically receiving surgical excision from January 2008 to June 2018. Body mass index (BMI), Glasgow prognostic score (GPS), systematic inflammatory index (SII), and controlling nutritional (CONUT) score were calculated as nutritional associated factors to evaluate their prognostic value. The primary outcome was overall survival (OS) while the secondary outcome was the postoperative length of hospitalization. The relationship between clinical features and outcomes were performed by Cox and logistic regression analysis, respectively. The independent prognostic factors were chosen to construct predicted model whose internal and external accuracy were validated by concordance index (C-index), Brier score, and calibration plots.Results: High score of GPS predicted worse OS [HR (95% CI): 3.122 (1.982-4.918) versus 2.208 (1.014-4.804)] and higher rank of CONUT predicted poorer prognosis [HR (95% CI): 2.573 (1.616-4.097)] independently. The CONUT score was selected as the only prognostic factor on the length of hospitalization [HR (95% CI): 2.137 (1.270-3.596)]. The nomogram plots were used to visualize the results of predicted models whose performance was evaluated from the aspects of calibration and discrimination. Conclusion: Our study suggested prognostic value of nutritional assessment indexes including GPS and CONUT score that appropriate preoperative intervention which could optimize patients’ nutrition associated indicators may improve prognosis on patients with high grade osteosarcoma receiving surgical excision.Level of evidence: Level Ⅲ, prognostic study

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“…The significance of the correlation between PLR and tumor prognosis remains controversial. Some studies have shown that pretreatment PLR is an independent prognostic factor for tumor outcome, 38,39 while others report the opposite findings 40,41 . Decreases in platelet count also appear during radiotherapy but are not as significant as lymphocytopenia.…”

Section: Discussionmentioning

confidence: 99%

Peripheral blood cell count ratios are predictive biomarkers of clinical response and prognosis for non‐surgical esophageal squamous cell carcinoma patients treated with radiotherapy

Zhi

Jiang

Shen

et al. 2020

Clinical Laboratory Analysis

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Background Peripheral blood cell count ratios, including the neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), and lymphocyte‐to‐monocyte ratio (LMR), have been reported to be prognostic factors in many malignancies as markers of inflammation and immune status. The aim of this study was to determine whether NLR, PLR, or LMR can be clinical response and prognostic biomarkers of non‐surgical esophageal squamous cell carcinoma (ESCC) patients treated with radiotherapy. Methods 193 non‐surgical ESCC patients who underwent radiotherapy were retrospectively analyzed. The peripheral blood cell count ratios were obtained before, during (weekly) and at the end of the treatment. Then, we compared the subsequent results with the corresponding pretreatment values and computed the rates of change, which were defined as cNLR, cPLR, and cLMR. Univariate and multivariate Cox regression analyses were used for overall survival (OS). Ordinal logistic regression was used to analyze the clinical response. Results In multivariate analysis, cNLR at week 4(P = .026) and week 5(P = .025) during radiotherapy were significantly associated with OS, along with BMI, tumor stage, tumor length, tumor location, and grade of adverse events. Besides, BMI, tumor stage, tumor length, adverse event grade, cNLR at week 4(P = .044) and week 5(P = .013), and cPLR at week 4(P = .034) and week 5(P = .015) were significantly associated with the clinical response in the multivariate logistic regression analysis. Conclusions The cNLR at weeks 4 and 5 was negatively correlated with the OS and clinical response of non‐surgical ESCC patients treated with radiotherapy. The elevated cPLR at weeks 4 and 5 was only related to poor clinical response.

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Prognostic significance of preoperative inflammatory response biomarkers in patients undergoing curative thoracoscopic esophagectomy for esophageal squamous cell carcinoma

Cited by 36 publications

References 22 publications

Prognostic and clinicopathological significance of platelet to lymphocyte ratio in esophageal cancer: a meta-analysis

Prognostic and clinicopathological significance of platelet to lymphocyte ratio in esophageal cancer: a meta-analysis

Prognostic Value of Various Nutritional Assessment Indicators on Long Term and Short Term Outcomes for Patients with High Grade Osteosarcoma Receiving Surgical Resection

Peripheral blood cell count ratios are predictive biomarkers of clinical response and prognosis for non‐surgical esophageal squamous cell carcinoma patients treated with radiotherapy

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