Prognostic significance of pre-resection albumin/fibrinogen ratio in patients with non-small cell lung cancer: A propensity score matching analysis

Chen, Shuaishuai; Yan, Haixi; Du, Jing; Li, Jun; Shen, Bo; Hu, Yan; Zhang, Ying

doi:10.1016/j.cca.2018.04.012

Cited by 34 publications

(25 citation statements)

References 27 publications

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“…Furthermore, Fib is also widely accepted as a reliable biomarker that reflects systemic inflammation and Fib can promote the synthesis of pro-inflammatory cytokines [23]. High Fib expression induced by the excess production of inflammatory cytokines may be associated with tumor aggressiveness in NSCLC patients [24]. Plasma Fib contributes to the coagulation status and promotes the survival and adhesion of tumor cells, which results in LC metastasis [25].…”

Section: Discussionmentioning

confidence: 99%

Pretreatment albumin/fibrinogen ratio as a promising predictor for the survival of advanced non small-cell lung cancer patients undergoing first-line platinum-based chemotherapy

Ying

Zhou

et al. 2019

BMC Cancer

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Background This study aimed to identify potential predictive factors for the survival of advanced non small-cell lung cancer (NSCLC) patients undergoing first-line platinum-based chemotherapy. Methods A total of 270 advanced NSCLC patients who underwent first-line platinum-based chemotherapy from June, 2011 to June, 2015 were enrolled. A receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive value of the albumin-to-fibrinogen ratio (AFR) for overall survival (OS). The predictive factors for survival were evaluated by univariate and multivariate analyses via the Cox proportional hazards regression model. The OS and progression free survival (PFS) results were determined via the Kaplan–Meier method using the log-rank analysis. Results Based on the results of the ROC curve analysis, 8.02 was accepted as the cut-off AFR value for OS. The metastasis stage (M0 vs M1a/b, HR: 1.73, 95% CI: 1.15–2.59, P = 0.020) and AFR (≤8.02 vs > 8.02, HR: 1.80, 95% CI: 1.09–2.78, P = 0.025) were two independent risk factors for PFS by multivariate Cox regression analysis. The AFR (≤8.02 vs > 8.02, HR: 1.79, 95% CI: 1.11–2.59, P = 0.029) was a significant predictive factor for OS in advanced NSCLC patients. The PFS ( P = 0.008) and OS ( P = 0.003) in the high AFR group were significantly improved compared with those in the low AFR group via the Kaplan–Meier method using the log-rank analysis. Conclusions The AFR could be a potential effective predictive factor for the survival in advanced NSCLC patients undergoing first-line platinum-based chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Pretreatment albumin/fibrinogen ratio as a promising predictor for the survival of advanced non small-cell lung cancer patients undergoing first-line platinum-based chemotherapy

Ying

Zhou

et al. 2019

BMC Cancer

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“…The findings from the present study showed some relationships between peripheral blood hematological and serological parameters, patient demographics, clinicopathologic characteristics, and patient prognosis in LSCC. There have been previous reports that high preoperative plasma levels of fibrinogen correlated with poor patient survival in esophageal squamous cell carcinoma [40,41] and advanced hypopharyngeal squamous cell carcinoma [42]. Pretreatment measurement of the NLR and the platelet-to-lymphocyte ratio (PLR) have been shown to be a useful complement to TNM staging in the prognostic assessment of patients with nasopharyngeal carcinoma (NPC) [43].…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Study of The Prognostic Significance of Preoperative Plasma Fibrinogen, Mean Platelet Volume, and the Neutrophil-to-Lymphocyte Ratio in Patients with Laryngeal Squamous Cell Carcinoma

Sheng

Zhang

et al. 2019

Med Sci Monit

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Background This study aimed to evaluate the prognostic significance of plasma fibrinogen, serum albumin, the mean platelet volume (MPV), and the neutrophil-to-lymphocyte ratio (NLR) in patients with laryngeal squamous cell carcinoma (LSCC) who underwent surgical resection. Material/Methods A retrospective study included 110 patients with LSCC who underwent surgical resection between January 2008 to June 2015. Clinicopathologic and demographic data were recorded. Preoperative levels of plasma fibrinogen, serum albumin, MPV, and NLR were measured, and all patients underwent postoperative follow-up. The Kaplan-Meier method was used to determine the impact of these factors on overall survival (OS) and disease-free survival (DFS). Results Preoperative hyperfibrinogenemia was significantly correlated with clinical stage, T stage, and tumor location in patients with LSCC (P<0.05). Serum albumin, MPV, and NLR were significantly correlated with the clinical stage and the T stage (P<0.05). The OS and DFS were significantly reduced in patients with hyperfibrinogenemia compared with patients with plasma fibrinogen <4 g/dL (P<0.05). Serum albumin of 35 g/L was not significantly correlated with OS (P>0.05). Patients with an MPV <9.5 fL had a significantly longer OS compared with patients with an MPV ≥9.5 fL (P=0.026). The DFS of patients with an NLR <2.22 was significantly longer than for those with an NLR ≥2.22. Conclusions Preoperative hyperfibrinogenemia, increased MPV and NLR were associated with reduced prognosis in patients with LSCC.

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“…Inflammatory mediators such as IL-6 are known to trigger the production of fibrinogen (10). One study reported that a higher preoperative fibrinogen level was associated with tumor development, indicating a poor prognosis in several types of malignancies (11). Although the exact reason for the association between elevated plasma fibrinogen and poor survival of patients with cancer remains unclear, several studies demonstrated that fibrinogen plays a key role in tumor progression.…”

Section: Editorialmentioning

confidence: 99%

The pretreatment circulating albumin-to-fibrinogen ratio in patients with non-small cell lung cancer: a simple, economical, and effective biomarker

et al. 2019

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Prognostic significance of pre-resection albumin/fibrinogen ratio in patients with non-small cell lung cancer: A propensity score matching analysis

Cited by 34 publications

References 27 publications

Pretreatment albumin/fibrinogen ratio as a promising predictor for the survival of advanced non small-cell lung cancer patients undergoing first-line platinum-based chemotherapy

Pretreatment albumin/fibrinogen ratio as a promising predictor for the survival of advanced non small-cell lung cancer patients undergoing first-line platinum-based chemotherapy

A Retrospective Study of The Prognostic Significance of Preoperative Plasma Fibrinogen, Mean Platelet Volume, and the Neutrophil-to-Lymphocyte Ratio in Patients with Laryngeal Squamous Cell Carcinoma

The pretreatment circulating albumin-to-fibrinogen ratio in patients with non-small cell lung cancer: a simple, economical, and effective biomarker

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