A Retrospective Study of The Prognostic Significance of Preoperative Plasma Fibrinogen, Mean Platelet Volume, and the Neutrophil-to-Lymphocyte Ratio in Patients with Laryngeal Squamous Cell Carcinoma

Sheng, Xiaoli; Zhang, Heng; Ge, Pingjiang; Chen, Liangsi; Zhang, Siyi

doi:10.12659/msm.914426

Cited by 15 publications

(10 citation statements)

References 45 publications

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“…33,34 The increase in fibrinogen in laryngeal cancer patients was related to a poor prognosis in previous studies. 35 This finding is consistent with that of our study. Moreover, fibrinogen was significantly associated with the OS of laryngeal cancer patients.…”

Section: Discussionsupporting

confidence: 94%

Prognostic Significance of a Model Based on Acetaldehyde Dehydrogenase 2 Genetic Polymorphisms in Laryngeal Carcinoma

Liang

et al. 2023

Otolaryngol.--head neck surg.

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ObjectiveBecause of the high costs associated with early‐stage laryngeal carcinoma diagnosis and prognosis prediction, this study attempts to find valuable targets to establish a novel predictive model by focusing on the aldehyde dehydrogenase 2 (ALDH2) genotype and other peripheral blood markers.Study DesignRetrospective study.SettingTertiary comprehensive hospital.MethodsFrom January 2011 to January 2021, 362 cases of laryngeal carcinoma were included and divided into 2 groups in this retrospective analysis. Information on medical history, alcohol, and tobacco consumption habits, ALDH2 genotypes, and other peripheral blood markers was collected. Endpoints of the current study included disease‐free survival and overall survival. A nomogram model for overall survival was established and evaluated using receiver operating characteristic (ROC) curves.ResultsA total of 236 patients were included in the training cohort, and the other 126 were included in the validation cohort. The median follow‐up of the patients was 9.6 years (interquartile range: 7.5‐12.5 years). Peripheral fibrinogen, hemoglobin, and ALDH2 genotypes were significantly associated with an increase in laryngeal carcinoma mortality rate on Kaplan‐Meier curves. The ROC curve showed that the effectiveness of overall survival prediction by the nomogram model was better than that of traditional clinical staging.ConclusionA prognostic nomogram of laryngeal carcinoma patients involving ALDH2 and peripheral blood markers and T and N stages was constructed and validated.

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Section: Discussionsupporting

confidence: 94%

Prognostic Significance of a Model Based on Acetaldehyde Dehydrogenase 2 Genetic Polymorphisms in Laryngeal Carcinoma

Liang

et al. 2023

Otolaryngol.--head neck surg.

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“… 3 Some laboratory inflammatory markers have been identified as prognostic markers for specific cancers, such as neutrophil granulosa cells, T lymphocytes, B lymphocytes, prominent cells, natural killer cells and mast cells, etc. 4 These inflammatory markers can produce chemokines, inflammatory mediators and cytokines, and their tumor–host interactions lead to systemic inflammatory responses. Recently, high NLR values have been proved to be an important prognostic factor in colorectal cancer, breast cancer, renal cell carcinoma and ovarian cancer.…”

Section: Introductionmentioning

confidence: 99%

Prognostic role of neutrophil-to-lymphocyte ratio to laryngeal squamous cell carcinoma: a meta-analysis

Zhao¹,

Qin²,

Qiu³

et al. 2022

Brazilian Journal of Otorhinolaryngology

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“…However, its predictive effect on prognosis has been confirmed in lung cancer, hepatocellular carcinoma, and so on [ 26 ]. FIB is also a prognostic factor for OS and disease-free survival, with a cutoff of 3.05 to 4.00 in LSCC [ 27 ]. Yanxy Han reports a significantly higher FIB in LSCC patients than in patients with benign laryngeal lesions [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

A Study of Peripheral Blood Parameters to Predict Response to Induction Chemotherapy and Overall Survival in Advanced Laryngeal Squamous Cell Carcinoma

et al. 2022

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Purpose: the purpose of this study was to screen peripheral blood parameters and construct models predicting the prognosis and induction chemotherapy (IC) response in locally advanced laryngeal squamous cell carcinoma (LSCC) patients. Methods: A total of 128 stage III/IVa LSCC patients (who required a total laryngectomy) were enrolled in a retrospective study from January 2013 to September 2020 at Beijing Tongren Hospital of Capital Medical University. Among them, 62 patients received IC (IC group), and 66 patients immediately underwent a total laryngectomy (TL) after diagnosis (surgery group). Demographic information and peripheral blood parameters were collected for further analysis. The overall survival (OS), progression-free survival (PFS), and disease-specific survival (DSS) were compared between the two groups. The prognosis and survival were also compared between patients with laryngeal function preservation (LFP) and those with TL. Results: The Receiver Operating Characteristic (ROC) curve for IC response in the IC group showed that the AUC of the blood model based on the four peripheral blood parameters of fibrinogen (FIB), platelet (PLT), high-density lipoprotein cholesterol (HDL), and albumin (ALB) was significantly higher than the TNM stage model’s AUC (0.7932 vs. 0.6568). We constructed a nomogram blood model to predict IC response (C-Index = 0.793). Regarding the OS of all patients, an ROC analysis for overall survival, the Kaplan–Meier (K-M) method with a log-rank test, and multivariate analysis indicated age, clinical stage, FIB, and hemoglobin (HGB) were independent prognostic factors for the OS of LSCC patients. The blood–clinical logistic model (AUC = 0.7979) was constructed based on the four prognosis factors, which were superior to the blood (AUC = 0.6867) or clinical models (AUC = 0.7145) alone to predict OS. We constructed a nomogram model based on age, clinical stage, FIB, and HGB to predict OS for LSCC patients (C-Index = 0.792). Besides this, there were no significant differences in OS, PFS, and DSS between IC and surgery groups or LFP and TL groups. Conclusion: Peripheral blood parameters help predict IC response and overall survival. Furthermore, induction chemotherapy significantly improves laryngeal function preservation without lowering the survival prognosis.

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A Retrospective Study of The Prognostic Significance of Preoperative Plasma Fibrinogen, Mean Platelet Volume, and the Neutrophil-to-Lymphocyte Ratio in Patients with Laryngeal Squamous Cell Carcinoma

Cited by 15 publications

References 45 publications

Prognostic Significance of a Model Based on Acetaldehyde Dehydrogenase 2 Genetic Polymorphisms in Laryngeal Carcinoma

Prognostic Significance of a Model Based on Acetaldehyde Dehydrogenase 2 Genetic Polymorphisms in Laryngeal Carcinoma

Prognostic role of neutrophil-to-lymphocyte ratio to laryngeal squamous cell carcinoma: a meta-analysis

A Study of Peripheral Blood Parameters to Predict Response to Induction Chemotherapy and Overall Survival in Advanced Laryngeal Squamous Cell Carcinoma

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