“…Third, 9 of the 23 articles were from China; selection bias may be in play because regional grouping was not considered. Additionally, most patients were male, which may reflect the nature of the disease per se, but may also reflect a gender bias [ 3 ]. These observations may explain the heterogeneity of our prognostic outcomes.…”
Section: Discussionmentioning
confidence: 99%
“…Laryngeal cancer is one of the most common cancers of the head and neck, associated with significant morbidity and mortality [ 1 , 2 ]. Internationally, approximately 1,700,000 cases of laryngeal squamous cell carcinoma (LSCC) are reported each year, and almost 90,000 patients die [ 3 ]. Despite significant advances in instruments such as flexible laryngoscopes, surgical methods, and chemoradiation therapy, the mortality rate remains high; the 5-year survival rate is 64% because about two-thirds of patients have advanced cancer at the time of diagnosis, rendering prognosis poor [ 1 ].…”
Section: Introductionmentioning
confidence: 99%
“…However, it is important to evaluate which factors are more important among various risk factors. However, such studies are insufficient [ 3 ]. Additionally, to the best of our knowledge, no meta-analysis has yet evaluated the impacts of individual risk factors (including comorbidities) on LSCC prognosis.…”
Objective: To assess the prognostic utilities of various risk factors for laryngeal squamous cell carcinoma. Methods: Six databases were searched to January 2022. Hazard ratios for overall survival and disease-free survival were collected and study characteristics were recorded. The risk of bias was evaluated using the Newcastle–Ottawa scale. Results: Twenty-eight studies involving 32,128 patients were finally included. In terms of overall survival, older age, a history of alcohol consumption, a high Charlson comorbidity index score, a high TNM stage (III and IV), a high tumor stage (III and IV), nodal involvement, poor pathological differentiation, primary chemoradiotherapy and radiotherapy were associated with increased risks of death. In terms of disease-free survival, older age (≥60 years), TNM stages III and IV, tumor stages III and IV, supraglottic tumors, and nodal involvement all increased the risk of death. Conclusions: The TNM stage importantly predicts overall survival, and tumor location predicts the disease-free survival of patients with laryngeal squamous cell carcinoma. Of patients with risk factors, the Charlson comorbidity index usefully predicts overall survival.
“…Third, 9 of the 23 articles were from China; selection bias may be in play because regional grouping was not considered. Additionally, most patients were male, which may reflect the nature of the disease per se, but may also reflect a gender bias [ 3 ]. These observations may explain the heterogeneity of our prognostic outcomes.…”
Section: Discussionmentioning
confidence: 99%
“…Laryngeal cancer is one of the most common cancers of the head and neck, associated with significant morbidity and mortality [ 1 , 2 ]. Internationally, approximately 1,700,000 cases of laryngeal squamous cell carcinoma (LSCC) are reported each year, and almost 90,000 patients die [ 3 ]. Despite significant advances in instruments such as flexible laryngoscopes, surgical methods, and chemoradiation therapy, the mortality rate remains high; the 5-year survival rate is 64% because about two-thirds of patients have advanced cancer at the time of diagnosis, rendering prognosis poor [ 1 ].…”
Section: Introductionmentioning
confidence: 99%
“…However, it is important to evaluate which factors are more important among various risk factors. However, such studies are insufficient [ 3 ]. Additionally, to the best of our knowledge, no meta-analysis has yet evaluated the impacts of individual risk factors (including comorbidities) on LSCC prognosis.…”
Objective: To assess the prognostic utilities of various risk factors for laryngeal squamous cell carcinoma. Methods: Six databases were searched to January 2022. Hazard ratios for overall survival and disease-free survival were collected and study characteristics were recorded. The risk of bias was evaluated using the Newcastle–Ottawa scale. Results: Twenty-eight studies involving 32,128 patients were finally included. In terms of overall survival, older age, a history of alcohol consumption, a high Charlson comorbidity index score, a high TNM stage (III and IV), a high tumor stage (III and IV), nodal involvement, poor pathological differentiation, primary chemoradiotherapy and radiotherapy were associated with increased risks of death. In terms of disease-free survival, older age (≥60 years), TNM stages III and IV, tumor stages III and IV, supraglottic tumors, and nodal involvement all increased the risk of death. Conclusions: The TNM stage importantly predicts overall survival, and tumor location predicts the disease-free survival of patients with laryngeal squamous cell carcinoma. Of patients with risk factors, the Charlson comorbidity index usefully predicts overall survival.
“…Neutrophils account for 50% to 80% of leukocytes, which are critical factors in cancer microenvironment. The ratio of neutrophil to lymphocyte is an independent predictor for LSCC overall survival and progression-free survival [ 31 , 32 ]. What is more, tumor-infiltrating neutrophils are found to promote LSCC progression [ 33 ].…”
Laryngeal squamous cell carcinoma (LSCC) is the main type of laryngeal cancer with poor prognosis. Incidence of LSCC increases every year, posing a great threat to human health. The underlying mechanism needs further study. Neutrophils are the most prevalent type of immune cells, which play vital roles in crosstalk between the microenvironment and cancer cells. In our study, we aim to figure out the complex regulation between neutrophils and LSCC. Our experiments showed that LSCC cells could promote the activation and mobility of neutrophils. And, in return, neutrophils enhanced the proliferation, migration, and invasion of LSCC. The subsequent results showed that IL-17 was highly expressed in neutrophil conditioned medium. Block of IL-17 could effectively inhibit the progression of LSCC induced by neutrophils. What is more, the results showed that IL-17 activated the JAK/STAT3 pathway in LSCC. Inhibition of the JAK/STAT3 pathway could significantly block neutrophil-induced LSCC progression. Our research reveals the complex interaction between neutrophils and LSCC cells, providing new ideas for the treatment of LSCC.
“…8 Many peripheral blood indices can reflect the corresponding nutrition state of the human body. Peripheral blood factors, including the neutrophillymphocyte ratio (NLR), 9,10 platelet count, 11 serum Alb systematic immune-inflammation index, 12 and peripheral T-cell subsets, 13 have been proposed as prognostic markers of laryngeal carcinoma in recent years. However, the mechanism between these indicators and the occurrence and development of laryngeal cancer has not been clarified.…”
ObjectiveBecause of the high costs associated with early‐stage laryngeal carcinoma diagnosis and prognosis prediction, this study attempts to find valuable targets to establish a novel predictive model by focusing on the aldehyde dehydrogenase 2 (ALDH2) genotype and other peripheral blood markers.Study DesignRetrospective study.SettingTertiary comprehensive hospital.MethodsFrom January 2011 to January 2021, 362 cases of laryngeal carcinoma were included and divided into 2 groups in this retrospective analysis. Information on medical history, alcohol, and tobacco consumption habits, ALDH2 genotypes, and other peripheral blood markers was collected. Endpoints of the current study included disease‐free survival and overall survival. A nomogram model for overall survival was established and evaluated using receiver operating characteristic (ROC) curves.ResultsA total of 236 patients were included in the training cohort, and the other 126 were included in the validation cohort. The median follow‐up of the patients was 9.6 years (interquartile range: 7.5‐12.5 years). Peripheral fibrinogen, hemoglobin, and ALDH2 genotypes were significantly associated with an increase in laryngeal carcinoma mortality rate on Kaplan‐Meier curves. The ROC curve showed that the effectiveness of overall survival prediction by the nomogram model was better than that of traditional clinical staging.ConclusionA prognostic nomogram of laryngeal carcinoma patients involving ALDH2 and peripheral blood markers and T and N stages was constructed and validated.
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