Prognostic Significance of Peripheral T‐Cell Subsets in Laryngeal Squamous Cell Carcinoma

Marchi, Filippo; Missale, Francesco; Incandela, Fabiola; Filauro, Marta; Mazzola, Francesco; Mora, Francesco; Paderno, Alberto; Parrinello, Giampiero; Piazza, Cesare; Peretti, Giorgio

doi:10.1002/lio2.304

Cited by 20 publications

(20 citation statements)

References 41 publications

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“…Peripheral CD8 + T cells was higher in lung cancer patients compared to the health, while CD3 + and CD4 + T cells, and CD4/CD8 ratio was signi cantly lower [22]. The relationship of lower CD4+/CD8 + ratios and recurrent disease and higher level of CD3+/CD4 + and nodal metastasis was found in laryngeal squamous cell cancer [16].…”

Section: Discussionmentioning

confidence: 80%

“…The metastasis of lung cancer is related to the increase of circulating tumor cells [14], which can be in uenced by the change of CD3+, CD4 + cells in peripheral blood [15]. A study about laryngeal squamous cell cancer indicates lower CD4+/CD8 + ratios are related to recurrent disease and a higher level of CD3 + and CD4 + is associated with nodal metastasis [16]. The increased risk of lung cancer is associated with low CD4 cell count and low CD4/CD8 ratio [17].…”

Section: Introductionmentioning

confidence: 99%

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The Relationship Between Lymphocyte Subsets and the Prognosis and Genomic Features of Lung Cancer: A Retrospective Study

Dai

Ren

et al. 2020

Preprint

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Abstract Background It has been shown that the prognosis of malignant tumors was closely related to the composition and function of immune system, which was associated with genomic features. However, the prognostic value of peripheral T lymphocyte subsets and its relationship with genomic features in lung cancer has not been analyzed extensively. Therefore, this study was intended to evaluate the relationship between lymphocyte subsets and the prognosis and genomic features of lung cancer. Methods 598 lung cancer patients with complete data were included in this study between 2011 and 2018. Kaplan-Meier method and Pearson analyses were conducted to study the prognostic value of CD3+, CD4+, CD8 + T lymphocytes and the rate of CD4/CD8. Results Patients with EGFR mutation has lower percentage of CD8 + lymphocytes than patients with EGFR wild-type (24.71 versus 26.62, respectively, P = 0.041). Patients with high CD3 + had better OS than those with low (27 versus 14 months, P = 0.002). OS of higher CD4 + and CD4/CD8 rate had longer OS than of lower (27 versus 12 months, P = 0.002; 25 versus 9 months, P = 0.008, respectively). Patients with high CD8 + had poor PFS than low group (6 versus 11 months, P = 0.009). There was a negative correlation between CD3 + and CD4 + cells and OS in smoking stage 2 female lung cancer patients (PCC = 0.626, P < 0.05; PCC = 0.534, P < 0.05, respectively). In stage 1 male lung cancer patients, CD8 + T cell is negatively correlated with OS and PFS (PCC = 0.295, P < 0.05; PCC = 0.280, P < 0.05, respectively) Conclusions Lung cancer patients with EGFR mutation had lower percentage of CD8 + lymphocytes. Lymphocyte subsets might be potential prognostic biomarkers of lung cancer, but they are affected by gender and tumor stage.

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Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

The Relationship Between Lymphocyte Subsets and the Prognosis and Genomic Features of Lung Cancer: A Retrospective Study

Dai

Ren

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Peripheral CD8+T cells was higher in lung cancer patients compared to the health, while CD3+ and CD4+T cells, and CD4/CD8 ratio was significantly lower 22 . The relationship of lower CD4+/CD8+ ratios and recurrent diseases and higher level of CD3+ and CD4+ cells and nodal metastasis was found in laryngeal squamous cell cancer 16 .…”

Section: Discussionmentioning

confidence: 81%

“…The metastasis of lung cancer is related to the increase of circulating tumor cells 14 , which can be influenced by the change of CD3+, CD4+ cells in peripheral blood 15 . A study about laryngeal squamous cell cancer indicates lower CD4/CD8 ratios are related to recurrent disease and a higher level of CD3 and CD4 is associated with nodal metastasis 16 . The increased risk of lung cancer is associated with low CD4 cell count and low CD4/CD8 ratio 17 .…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Lymphocyte Subsets and the Prognosis and Genomic Features of Lung Cancer: A Retrospective Study

Dai¹,

Ren²,

Ren³

et al. 2021

Int. J. Med. Sci.

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Background: It has been shown that the prognosis of malignant tumors was closely related to the composition and function of immune system, which was associated with genomic features. However, the prognostic value of peripheral T lymphocyte subsets and its relationship with genomic features in lung cancer has not been analyzed extensively. Therefore, this study was intended to evaluate the relationship between lymphocyte subsets and the prognosis and genomic features of lung cancer. Methods: 598 lung cancer patients with complete data were included in this study between 2011 and 2018. Kaplan-Meier method and Pearson analyses were conducted to study the prognostic value of CD3+, CD4+, CD8+ T lymphocytes and the rate of CD4/CD8. Results: Patients with EGFR mutation has lower mean percentage of CD8+ lymphocytes than patients with EGFR wild-type (24.71 versus 26.62, respectively, P =0.041). Patients with high CD3 had better OS than those with low (27 versus 14 months, P =0.002). Patients with higher CD4 and CD4/CD8 rate had longer OS than with lower (27 versus 12 months, P =0.002; 25 versus 9 months, P =0.008, respectively). Patients with high CD8 had poor PFS than low group (6 versus 11 months, P =0.009). There was a negative correlation between CD3+ and CD4+ cells and OS in smoking stage Ⅱ female lung cancer patients (PCC = 0.626, P <0.05; PCC = 0.534, P <0.05, respectively). In stage Ⅰ male lung cancer patients, CD8+T cell is negatively correlated with OS and PFS (PCC = 0.295, P <0.05; PCC = 0.280, P <0.05, respectively) Conclusions: Lung cancer patients with EGFR mutation had lower percentage of CD8+ lymphocytes. Lymphocyte subsets might be potential prognostic biomarkers of lung cancer, but they are affected by gender and tumor stage.

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“…Similar to other malignancies, neutrophils were found at elevated levels in the peripheral blood of HNSCC patients, and their frequencies were inversely correlated with the frequencies of lymphocytes (89,90). Patients with HPV-associated tumors had significantly lower levels of circulating neutrophils compared to patients with HPV-negative tumors, and the high absolute number of neutrophils correlated with poor prognosis in HPVpositive patients but not HPV-negative patients (91).…”

Section: Neutrophilsmentioning

confidence: 73%

Immunological Network in Head and Neck Squamous Cell Carcinoma—A Prognostic Tool Beyond HPV Status

et al. 2020

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Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous disease that affects more than 800,000 patients worldwide each year. The variability of HNSCC is associated with differences in the carcinogenesis processes that are caused by two major etiological agents, namely, alcohol/tobacco, and human papillomavirus (HPV). Compared to non-virally induced carcinomas, the oropharyngeal tumors associated with HPV infection show markedly better clinical outcomes and are characterized by an immunologically "hot" landscape with high levels of tumor-infiltrating lymphocytes. However, the standard of care remains the same for both HPV-positive and HPV-negative HNSCC. Surprisingly, treatment de-escalation trials have not shown any clinical benefit in patients with HPV-positive tumors to date, most likely due to insufficient patient stratification. The in-depth analysis of the immune response, which places an emphasis on tumor-infiltrating immune cells, is a widely accepted prognostic tool that might significantly improve both the stratification of HNSCC patients in de-escalation trials and the development of novel immunotherapeutic approaches.

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Prognostic Significance of Peripheral T‐Cell Subsets in Laryngeal Squamous Cell Carcinoma

Cited by 20 publications

References 41 publications

The Relationship Between Lymphocyte Subsets and the Prognosis and Genomic Features of Lung Cancer: A Retrospective Study

The Relationship Between Lymphocyte Subsets and the Prognosis and Genomic Features of Lung Cancer: A Retrospective Study

The Relationship between Lymphocyte Subsets and the Prognosis and Genomic Features of Lung Cancer: A Retrospective Study

Immunological Network in Head and Neck Squamous Cell Carcinoma—A Prognostic Tool Beyond HPV Status

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