The Relationship Between Lymphocyte Subsets and the Prognosis and Genomic Features of Lung Cancer: A Retrospective Study

Abstract

<jats:title>Abstract</jats:title> <jats:p>Background It has been shown that the prognosis of malignant tumors was closely related to the composition and function of immune system, which was associated with genomic features. However, the prognostic value of peripheral T lymphocyte subsets and its relationship with genomic features in lung cancer has not been analyzed extensively. Therefore, this study was intended to evaluate the relationship between lymphocyte subsets and the prognosis and genomic features of lung cancer. Methods 598 lung cancer patients with complete data were included in this study between 2011 and 2018. Kaplan-Meier method and Pearson analyses were conducted to study the prognostic value of CD3+, CD4+, CD8 + T lymphocytes and the rate of CD4/CD8. Results Patients with EGFR mutation has lower percentage of CD8 + lymphocytes than patients with EGFR wild-type (24.71 versus 26.62, respectively, <jats:italic>P</jats:italic> = 0.041). Patients with high CD3 + had better OS than those with low (27 versus 14 months, <jats:italic>P</jats:italic> = 0.002). OS of higher CD4 + and CD4/CD8 rate had longer OS than of lower (27 versus 12 months, <jats:italic>P</jats:italic> = 0.002; 25 versus 9 months, <jats:italic>P</jats:italic> = 0.008, respectively). Patients with high CD8 + had poor PFS than low group (6 versus 11 months, <jats:italic>P</jats:italic> = 0.009). There was a negative correlation between CD3 + and CD4 + cells and OS in smoking stage 2 female lung cancer patients (PCC = 0.626, P &lt; 0.05; PCC = 0.534, P &lt; 0.05, respectively). In stage 1 male lung cancer patients, CD8 + T cell is negatively correlated with OS and PFS (PCC = 0.295, P &lt; 0.05; PCC = 0.280, P &lt; 0.05, respectively) Conclusions Lung cancer patients with EGFR mutation had lower percentage of CD8 + lymphocytes. Lymphocyte subsets might be potential prognostic biomarkers of lung cancer, but they are affected by gender and tumor stage.</jats:p>

Association of Lymphocyte Subsets in Advanced Non-Small Cell Lung Cancer Patients with the Efficacy and Prognosis of Immune Checkpoint Inhibitor Therapy: A Retrospective Study

“…Results showed that NK cells were higher in males, proportion of CD4 + T cells and CD4 + /CD8 + ratio was lower in patients ≥65 years of age, CD8 + T cells were higher in peripheral blood for patients with adenocarcinoma, percentage of Tregs was higher in stage IV patients with distant metastasis, percentage of CD8 + T cells was lower and CD4 + /CD8 + ratio was higher in patients with EGFR mutations. This is consistent with the ndings of Mazzaschi et al [12,13,14].…”

The Effect of Microwave Ablation Combined with Anti-PD-1 Monoclonal Antibody on T Cell Subsets and Long-Term Prognosis in Patients Suffering from Non-Small-Cell Lung Cancer

“…CD4+ T lymphocytes, as auxiliary T cells, can not only play a direct killing role on tumor cells but also have immune memory function, playing a secondary immune role. CD8+ T lymphocytes are cytotoxic T lymphocytes, which can negatively regulate tumor immune response and can be used to evaluate the patient's autoimmune function [13,14]. In the process of the development of NSCLC, apoptosis of tumor-specific T cells and PD-1dependent and PD-1-independent mechanisms of mediation are closely related.…”

A validated nomogram integrating baseline peripheral T-lymphocyte subsets and NK cells for predicting survival in stage I–IIIA non-small cell lung cancer after resection

“…All enrolled patients received treatment involving traditional Chinese medicine. Previously, we conducted several clinical studies (9,30) confirming that traditional Chinese medicine prolonged DFS in lung cancer patients, especially those after radical resection of non-advanced lung adenocarcinoma. The intervention of traditional Chinese medicine reduced the progressive disease rate, and thus the number of outcome events was reduced correspondingly.…”

“…The cancer cells may escape from the immune attack in the presence of immune function and pathological changes when aberrant alternation in the quantity and function of the T cell subsets happens (29). The high percentages of peripheral CD3 + , CD4 + T cells and CD4/ CD8 ratio were associated with longer OS in lung cancer patients (30). The increased risk of lung cancer is related to low CD4 cell count and low CD4/CD8 ratio (31).…”