Prognostic significance of p53 codon 72 polymorphism in lung carcinomas

Wang, Yi‐Ching; Lee, H. S.; Chen, S. K.; Chang, Yuan Yen; Chen, Chih-Yi

doi:10.1016/s0959-8049(98)00369-4

Cited by 81 publications

(52 citation statements)

References 14 publications

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“…A recent meta-analysis also provides evidence that the Pro allele increases the risk of gastric cancer in Asians . Gao et al, (2009) (Hiyama et al, 2002;Sul et al, 2006), lung cancer Wang et al, 1999), breast cancer Papadakis et al, 2000), bladder cancer (Pandith et al, 2010). However, these results are not consistent, as many studies reported differently.…”

Section: Discussionmentioning

confidence: 94%

p53 Codon 72 Polymorphism Interactions with Dietary and Tobacco Related Habits and Risk of Stomach Cancer in Mizoram, India

Malakar¹,

Devi²,

Phukan³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 94%

p53 Codon 72 Polymorphism Interactions with Dietary and Tobacco Related Habits and Risk of Stomach Cancer in Mizoram, India

Malakar¹,

Devi²,

Phukan³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…For p53 Pro72Arg SNP, Wang et al (1999) reported that lung cancer patients with the Pro/ Pro genotype had a worse prognosis compared with those with Arg/Pro genotypes, especially for patients with squamous cell lung cancer (P ¼ 0.013), male patients (P ¼ 0.028) and those aged 60-69 years (P ¼ 0.052). In patients with early stage lung cancer, patients with Pro/Pro and Arg/Arg genotypes had a tendency for a worse prognosis than those with the Arg/ Pro genotype (P ¼ 0.057).…”

Section: Genetic Polymorphisms In Natural History Of Diseasementioning

confidence: 99%

Genetic susceptibility to tobacco-related cancer

et al. 2004

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Although cigarette smoking is the dominant risk factor for several epithelial cancers, only a small fraction of individuals with tobacco exposure develop cancer. The underlying hypothesis is that genetic factors may render certain smokers more susceptible to cancer than others. Genetic alterations in critical regulatory pathways may predispose cells to carcinogenesis. These pathways include regulation of xenobiotic metabolism; control of genomic stability, including DNA repair mechanisms, cell-cycle checkpoints, apoptosis and telomere length; and control of microenvironmental factors, such as matrix metalloproteinases, inflammation and growth factors. In addition, epigenetic events, such as promoter hypermethylation and loss of imprinting, are also involved in carcinogenesis. In this review, we will summarize recent advances in genetic susceptibility to tobacco-related cancer. Emphasizing on risk assessment, we will describe how genetic variations in the above-mentioned genetic pathways modify the tobacco-related cancer risk. In addition, we will discuss how genetic variations may assist in predicting clinical outcome, such as the natural history of cancer and treatment response. The measurements of genetic susceptibility by both genotypic and phenotypic assays are covered in the text. Finally, we present a number of current concerns that need to be addressed as the exciting field of molecular cancer epidemiology advances rapidly.

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“…There are several differences among the p53 variants in their ability to bind components of the transcriptional machinery, to activate transcription, to induce apoptosis, and to repress the transformation of primary cells (7). This polymorphism has been associated with the susceptibility of several human cancers (8 -12) and prognosis (13). Patients with the Pro/Pro genotype are more likely to develop lung cancer than those with other genotypes (14 -16), particularly patients who are smokers.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of TP53 Codon 72 Polymorphism in Advanced Gastric Adenocarcinoma

Zhang¹,

Laurence²,

Hollowood³

et al. 2004

Clinical Cancer Research

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Purpose: A common polymorphism of the tumor suppressor gene TP53 at codon 72 has been associated with human cancer susceptibility. The prognostic role of the polymorphism was assessed in 102 patients with advanced gastric adenocarcinoma.Experimental Design: We followed up 102 consecutive Caucasian patients with advanced gastric adenocarcinoma for >5 years and determined the status of the TP53 codon 72 polymorphism in DNA samples extracted from archived gastric tissues.Results: The frequency of the arginine homozygous allele was positively correlated to patient age at baseline (P ‫؍‬ 0.002). However, the age-related increase in the percentage of codon 72 arginine p53 was not correlated to the prognosis for gastric cancer patients. Multivariable analysis in patients who had surgery showed that baseline age may be inversely associated with patient survival (odds ratio, 1.1; 95% confidence interval, 1.0 -1.2; P ‫؍‬ 0.02). Furthermore, alcohol consumption may be associated with reduced survival (P ‫؍‬ 0.06).Conclusions: These findings indicate that codon 72 arginine p53 may not be associated with a prolonged survival in patients with advanced gastric adenocarcinoma, but further study is needed to assess whether this polymorphism is associated with a late onset or slow progress of early gastric adenocarcinoma.

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Prognostic significance of p53 codon 72 polymorphism in lung carcinomas

Cited by 81 publications

References 14 publications

p53 Codon 72 Polymorphism Interactions with Dietary and Tobacco Related Habits and Risk of Stomach Cancer in Mizoram, India

p53 Codon 72 Polymorphism Interactions with Dietary and Tobacco Related Habits and Risk of Stomach Cancer in Mizoram, India

Genetic susceptibility to tobacco-related cancer

Prognostic Value of TP53 Codon 72 Polymorphism in Advanced Gastric Adenocarcinoma

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