Prognostic Significance of Œstrogen Uptake by Human Breast-Cancer Tissue

Braunsberg, Hannelore; James, V. H. T.; Irvine, W. T.; James, Frances; Jamieson, C. W.; Sellwood, R A; Carter, A.E.; Hulbert, M.

doi:10.1016/s0140-6736(73)90001-9

Cited by 30 publications

(5 citation statements)

References 8 publications

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“…(Jensen et al, 1971). Similar reports on tumor regression and its relationship to estrogen receptor have been reported by several other independent study groups (Savlov et al, 1974;Mass et al, 1972;Braunsberg et al, 1973).…”

Section: Introductionsupporting

confidence: 84%

Estrogen and estrogen receptors of breast cancer

Sahadevan

Perlia

Economou

et al. 1975

Journal of Surgical Oncology

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Human breast cancer can be divided into a group that contains specific receptor sites for estrogen and a group without such specific estrogen-binding sites. The presence of specific estrogen receptors in some tumors indicating hormonal dependency has been shown to be of predictive value for endocrine treatment. This would greatly improve therapeutic planning for patients with breast cancer. Tumor tissue from 52 patients was investigated for content of both cytosol estrogen and estrogen receptor. In addition, the total tumor estrogen was also determined in 14 of these tumors. The results of this investigation show two distinct groups: one group containing both estrogen receptor and estrogen and a second group with no receptor but with measurable amount of estrogen. Tumors with estrogen receptors have higher tissue levels of estrogen than tumors without specific estrogen receptor. Even in the absence of estrogen recptor, however, most tumor tissue examined contained a measurable amount of estrogen.

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Section: Introductionsupporting

confidence: 84%

Estrogen and estrogen receptors of breast cancer

Sahadevan

Perlia

Economou

et al. 1975

Journal of Surgical Oncology

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“…Evidence for a similar correlation in human breast cancer was reported by Jensen et al (1972) and Maass et al (1972). An increased in-vivo uptake of injected radiolabelled oestrogens by human breast cancers was also shown in patients who subsequently responded to endocrine therapy (Folca et al, 1961;Braunsberg et al, 1973).…”

Section: Introductionsupporting

confidence: 80%

Oestrogen Receptor in Human Breast Cancer Tissue and Response to Endocrine Therapy

Engelsman¹,

Persijn²,

Korsten³

et al. 1973

BMJ

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“…The difference in average interval between cases that did not show variation (9.6 months) and those that did vary (19. 3 months) suggests that variation may be more likely to occur with later metastases. However, there was considerable overlap in the range of intervals.…”

mentioning

confidence: 99%

Estrogen receptor protein (ERP) in multiple tumor specimens from individual patients with breast cancer

Rosen

Menendez‐Botet

Urban

et al. 1977

Cancer

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We have studied 29 patients from whom two or more spatially and temporally separate samples of breast carcinoma were obtained for ERP analysis. Differences in ERP were obtained in 24% of all cases studied. The greatest degree of variation was found when comparing a primary tumor with a subsequent metastasis (38%). Among eight patients with ERP negative (-) primary tumors, six had ERP (-) and two ERP positive (+) metastases. Among 11 patients with ERP (+) primaries eight had ERP (+) and three ERP (-) metastases. Variations were found in 20% of multiple nonsimultaneous metastases from individual patients. The difference in average interval between cases that did not show variation (9.6 months) and those that did vary (19.3 months) suggests that variation may be more likely to occur with later metastases. However, there was considerable overlap in the range of intervals. These findings underscore the need to biopsy readily accessible recurrences rather than to rely on the results of prior specimens. There was no apparent consistent relationship of these variations to age, site of specimen, interval between specimens or the histologic features of the tissues submitted for analysis. Two patients with an ERP (+) primary tumor had ERP (-) metastases after interval therapy. Similar variations were observed in patients who did not have interval therapy. The data do not permit any definite conclusions as to the effect of chemotherapy or radiation on the ERP properties of mammary carcinoma. Cancer 39 : 2 194-2200, 1977. STROGEN RECEPTOR PROTEIN ASSAY OF E breast carcinoma provides a helpful guide for predicting response to hormonal therapy in patients with metastatic breast carcinoma. l7 Nearly two-thirds of patients with an ERP positive tumor specimen have been reported to respond favorably while less than 10% of patients with ERP negative tumors experienced similar improvement. la Failure to obtain higher response rates in favorable cases could reflect differences in the ERP properties among tumor cells, 24332 the importance of other hormonal receptors , 13915 or other variations in metabolic

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Prognostic Significance of Œstrogen Uptake by Human Breast-Cancer Tissue

Cited by 30 publications

References 8 publications

Estrogen and estrogen receptors of breast cancer

Estrogen and estrogen receptors of breast cancer

Oestrogen Receptor in Human Breast Cancer Tissue and Response to Endocrine Therapy

Estrogen receptor protein (ERP) in multiple tumor specimens from individual patients with breast cancer

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