Prognostic significance of Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma

Abstract

BackgroundOct4 and Sox2 are two major transcription factors related to the stem cell self-renewal and differentiation. The aim of this study was to examine the association between Oct4 and Sox2 expression levels with both the clinicopathological characteristics and prognoses of patients with hypopharyngeal squamous cell carcinoma.MethodTumor tissue samples from 85 patients with hypopharyngeal squamous cell carcinoma were collected, and the clinical follow-up data of these patients were recorded, and expression status of Oct4 and Sox2 were examined in these tissue samples by immunohistochemistry (IHC).ResultsOct4 expression was found to be an independent predictive factor for overall survival (p = 0.004) in patients with hypopharyngeal squamous cell carcinoma and was independently related to loco-regional control (p = 0.001). Although Sox2 expression status showed no significant association with overall survival (p = 0.166), disease-free survival (p = 0.680) or loco-regional control (p = 0.383), when using a subgroup analysis, the subgroup with both high Oct4 and Sox2 expression had the best prognosis (p = 0.000). Sox2 expression could be a potential prognostic predictor for patients with hypopharyngeal squamous cell carcinoma. Simultaneous analyses of Oct4 and Sox2 expression could be more effective in evaluating the prognoses of patients with hypopharyngeal squamous cell carcinoma.ConclusionOct4 expression is an independent predictive factor for patients with hypopharyngeal squamous cell carcinoma, suggesting that Oct4 expression may be a useful indicator for predicting the prognosis of hypopharyngeal squamous cell carcinoma.

Association of differential β‐catenin expression with Oct‐4 and Nanog in oral squamous cell carcinoma and their correlation with clinicopathological factors and prognosis

“…Consistent with the findings of Ge et al [35] and Chiou et al [3], nuclear expression of Similar to Oct-4, Nanog is a pluripotent marker essential to maintain the self renewal of embryonic stem cells. Recently, the expression of Nanog was found in several tumors including oral squamous cell carcinoma [18][19][20]3].…”

The prognostic value of combination of CD90 and OCT4 for hepatocellular carcinoma after curative resection

“…Normally, expression of OCT4 is con ned to pluripotent cells in the developing embryo [18,19]. Recently, OCT4 expression had been observed in cancer cells of some malignancies, such as breast and prostate cancer, bladder cancer and HCC [20][21][22][23]. Latest studies demonstrated that OCT4 plays crucial roles in the malignant behavior of embryonic stem cells (ESCs) [24].…”

High sex determining region Y-box 2 expression is a negative predictor of occult lymph node metastasis in early squamous cell carcinomas of the oral cavity

“…4,5,12 In lung cancer, SOX2 overexpression is associated with favourable prognosis, whereas the relevance of SOX2 expression for prognosis of HNSCC is controversial. [13][14][15] Sentinel node biopsy (SNB) of the N0 neck in early oral SCC has been shown in several studies to reliably detect occult neck metastasis with negative predictive values >95%. To clarify a potential prognostic relevance for occult metastasis of SOX2 protein expression, we consequently analysed a very well defined patient cohort with early oral SCC (T1/T2-stage) undergoing sentinel lymph node biopsy.…”