Prognostic significance of mucinous component in colorectal carcinoma

Abstract

Colorectal mucinous carcinomas present at a more advanced stage, predominantly in men, with higher right colon location rate, and a worse overall 5-year survival rate than the non-mucinous colorectal cancers.

TNM Stages and Prognostic Features of Colorectal and Mucinous Adenocarcinoma Patients: a Meta Analysis

“…There are 3759 English literatures in original search, after exclusion and screening, 28 English literatures (Cusack et al, 1996;Sun et al, 1996;Wu et al, 1996;Enriquez et al, 1998;Cerottini et al, 1999;Consorti et al, 2000;Nozoe et al, 2000;Kanemitsu et al, 2003;Chen et al, 2004;Du et al, 2004;Papadopoulos et al, 2004;Kang et al, 2005;You et al, 2006;Grillo-Ruggieri et al, 2007;Hill et al, 2007;Lee et al, 2007;Farhat et al, 2008;Pande et al, 2008;Catalano et al, 2009;Min et al, 2009;Song et al, 2009;Xie et al, 2009;Sultan et al, 2010;Catalano et al, 2011;Jivapaisarnpong et al, 2011;Hyngstrom et al, 2012;Langner et al, 2012;Yamaguchi et al, 2012) and 2 Chinese literatures (Songqing et al, 2002;Miao et al, 2005) meet the requirements. In the 30 literatures, 21 literatures can be used for Meta analysis of the relationship of mucinous adenocarcinoma and TNM staging, including 444489 cases, in which mucinous adenocarcinoma were 45050 cases, accounting for 10.1% of all cases; 21 literatures can be used for Meta analysis of relationship of mucinous adenocarcinoma and prognosis, including 450804 cases, in which mucinous adenocarcinoma were 45354 cases, accounting for 10.1% of all cases.…”

“…Due to the heterogeneity (I 2 =88%; P<0.001), we removed the large heterogeneity literatures, including Du et al (2004), Hyngstrom et al (2012), Kane mitsu et al (2003), Kang et al (2005), Lee et al (2007), Papadopoulos et al (2004), then the heterogeneity was reduced significantly (I 2 =33%; P=0.1), the analysis results were consistent with previous overall analysis, the HR value was 1.48 (CI: 1.35-1.62; P<0.001), suggesting that the meta-analysis results are accurate and reliable (Figure 2). …”

“…The definition of mucinous adenocarcinoma was that the mucus is more than 50% in adenocarcinoma according to World Health Organization (WHO) (Jass et al, 1989), and the mucinous adenocarcinoma was 1.5%-25.4% of all colorectal cancer (Papadopoulos et al, 2004;Pande et al, 2008). With the deeply study of biological behavior and pathological features of colorectal cancer, we recognized the pathological types and prognosis were closely related.…”

Effect of mucin production on survival in colorectal cancer: A case-control study

“…There is evidence that mucinous colorectal cancer (MCRC) may be a distinct biological and genetic entity compared with non-mucinous adenocarcinoma (NMCRC) [2,3] . Thus patients with MCRC may be younger [4,5] , their tumors are more likely to be right-sided [6][7][8] , and they present at a more advanced stage [3,4,6,8] . In addition, these tumors may have distinct mutations and cytogenetic abnormalities [2,9] and may be less likely to respond to chemotherapy [10][11][12] .…”

“…The reasons for the conflicting reports are not clear. In many studies, there was no control for, age, sex, tumor stage or location [4,6,7,10] . In addition, the prognostic significance of having an extracellular mucinous component that is much larger than 50% is not known.…”