TNM Stages and Prognostic Features of Colorectal and Mucinous Adenocarcinoma Patients: a Meta Analysis

Abstract

Aim: The significance of the mucinous adenocarcinoma in TNM staging and prognosis for colorectal tumor patients is still controversial. The aim was to provide a meta-analysis for TNM staging and prognostic features of colorectal tumors. Methods: 30 individual case-control studies were finally included into this meta-analysis, involving a total of 444,489 cancer cases and 45,050 mucinous adenocarcinomas, of relations with TNM staging and prognostic features. Results: Compared to non-mucinous adenocarcinoma patients, the TNM IV stage accounted for a larger percentage of mucinous adenocarcinomas (OR=1.48, 95%CI 1.28-1.71, POR<0.001) and the prognosis was significantly poor (HR=1.06, 95%CI 1.04-1.08, P<0.001). After heterogeneity testing, the results was similar to the holistic approach outcome (HR=1.48, 95%CI 1.35-1.62, P<0.001). Conclusion: Compared to patients with non-mucinous adenocarcinomas, mucinous adenocarcinoma patients with later TNM staging make up a big percentage, and mucinous adenocarcinoma is an independent risk factor for poor prognosis.

Matrix metalloproteinase 9 -1562C/T polymorphism increased protein levels in patients with colorectal cancer in a sample from southeastern Brazil

“…Similarly, Zeng et al (1996) found that MMP-9 levels were 5-fold greater in CRC compared to the normal mucosa (Zeng et al, 1996). Other studies also found a similar relationship between MMP-9 and metastasis (Yamada et al, 2010;Chen et al, 2012;Herszényi et al, 2012). The contradictory results regarding MMP-9 expression and its relationship with invasion, lymph node involvement, and distant metastasis were because of the different sources of the samples.…”

“…Interestingly, signet ring cells were present almost exclusively in females (90%; P = 0.0177). Although previous studies found no clear relationship between the presence of mucus and survival, most studies agree that these patients have worse prognosis and shorter survival compared to patients with non-mucinous tumors (Henrique-Filho et al, 2004;Chen et al, 2012;Numata et al, 2012).…”

“…Adenocarcinoma with a mucinous component represents approximately 23% of tumors (Langers et al, 2008;Chen et al, 2012). According to the literature, this component, regardless of tumor differentiation status, implies a worse prognosis.…”

Prognostic Significance of Mucinous Histologic Subtype on Oncologic Outcomes in Patients With Colorectal Cancer

“…Currently, mucinous histology does not influence treatment decision-making for this cancer [11]. However, evidence has suggested that a MCC is a biologically distinct disease requiring special clinical consideration and treatment strategy [121314]. This study aims to investigate the clinicopathological features of MCCs and to identify the relationship between this histology and patients' oncologic outcomes.…”

Resection of Liver Metastases From Colorectal Mucinous Adenocarcinoma

“…[13][14][15][16][17][18] They have also been associated with a worse prognosis. 15,[19][20][21] However, all studies of mucinous adenocarcinomas have focused on either nonmetastatic or unresectable stage IV colorectal cancers. No study has evaluated the impact of mucinous characteristics on candidates for LR of CRLM.…”