Prognostic significance of mucinous carcinoma of colon and rectum: A prospective case-control study

Prognostic Implications of Mucinous Differentiation in Metastatic Colorectal Carcinoma Can Be Explained by Distinct Molecular and Clinicopathologic Characteristics

“…We report an overall incidence of 14.8% in a large cohort of almost 1900 patients. These results concur with previous estimates of 15% in a US-based report [33] and 10-20% in other western populations [34,35]. …”

Mucinous subtype as prognostic factor in colorectal cancer: a systematic review and meta-analysis

“…These results were not analysed stage by stage; therefore, it is possible they only reflect the fact that MAC presented in these studies in a more advanced stage. Other studies could not demonstrate a difference in disease recurrence or curative resection rate in MAC 4 21 23 24 44. It was not possible to perform a meta-analysis for the outcome parameters recurrence rate and curative resection rate due to a lack of data in the included reports.…”

“…Some authors have indeed shown a worse survival in mucinous cancers,21 22 while others did not find any adverse prognostic effect 23 24. Interestingly, mucinous tumours were recently shown to be associated with a poorer response to adjuvant chemotherapy25 26 and chemoradiotherapy 27…”

Management of Colorectal Carcinoma in Children and Young Adults

“…[2][3][4] In a recent review of 77 children with CRC who presented to St Jude Children's Research Hospital, patients had experienced symptoms for a median of 3 months and most were anemic. 1,26 However, while vigilance for pediatric CRC remains important, adult-type screening exams (eg, colonoscopy, routine fecal occult blood testing, and sigmoidoscopy) are not likely to be cost-effective and will generally identify many false positives in the absence of known risk factors. As in most other series (summarized in Saab and Furman 4 ), 66 of 77 patients (86%) at St Jude presented with advanced-stage disease, 48 (62%) had mucinous histology, 33 (43%) had >10% signet-ring cells, and the 10-year event-free survival estimate overall was only 17.7% ± 5.1%.…”