Mucinous subtype as prognostic factor in colorectal cancer: a systematic review and meta-analysis

Verhulst, Johanna; Ferdinande, Liesbeth; Demetter, Pieter; Ceelen, Wim

doi:10.1136/jclinpath-2011-200340

Cited by 228 publications

(238 citation statements)

References 72 publications

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“…In another study conducted by Kanemistu et al [22], MA patients with either complete or incomplete surgical resection had worse outcomes compared to non-mucinous types. Moreover, MA was associated with a 2–8% increase in risk of death in Verhulst et al’s meta-analysis [23].…”

Section: Discussionmentioning

confidence: 92%

“…Of note, patients with colonic MA tend to be younger, tend to present with advanced stage, and more likely to have right-sided tumors, peritoneal metastasis, and incomplete resection of the colonic tumor [22,23,26,27]. Microsatellite instability (MSI) of more than 40% frequently occurs in right-sided colonic cancer and carries better prognostic outcomes compared to microsatellite stable (MSS) tumors [11,26].…”

Section: Discussionmentioning

confidence: 99%

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Factors associated with short recurrence-free survival in completely resected colon cancer

Alnimer

Ghamrawi

Aburahma

et al. 2017

Journal of Community Hospital Internal Medicine Perspectives

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Background: Several factors could affect disease recurrence in surgically resected colon cancer. While the role of certain factors such as cancer stage and grade is well established, the role of other factors (e.g., histological subtypes) is yet to be determined. Objective:Therefore, we conducted a study to evaluate the impact of several factors in recurrence-free survival (RFS) in patients who were disease free following surgical resection of the colon cancer. Design/Methods: Data were collected for patients with Stage I–III colon cancer who underwent complete surgical resection of the tumor between January 2010 and December 2015 in our institution. A total of 90 subjects met the inclusion criteria and were included in the study. The following factors were collected at the time of surgical resection of the colonic tumor: patient’s age, gender, colon cancer stage, grade and histological subtype, body mass index, hemoglobin A1c, and smoking history. Results: A total of 28 patients (31%) developed recurrence and had a mean follow-up time of 19.8 months (range: 2–54.4 months). Median RFS was 54.4 months with a 5-year RFS of 49%. Advanced colonic cancer stage and mucinous histological subtype were associated with shorter RFS with an HR of 2.37, 95% CI = 1.38–4.06, and 95% CI = 1.02–5.90, respectively. Current smokers or those who quit less than 15 years earlier tended to have worse RFS with an HR of 2.47, 95% CI = 0.98–6.27. Conclusion: Advanced colon cancer stage and mucinous histological subtype are independent risk factors for cancer recurrence and shorter RFS in completely resected colonic tumor.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Factors associated with short recurrence-free survival in completely resected colon cancer

Alnimer

Ghamrawi

Aburahma

et al. 2017

Journal of Community Hospital Internal Medicine Perspectives

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“…A recent meta-analysis of mucinous cancers of the colon and rectum showed a worse prognosis for mucinous cancers compared with nonmucinous types, even when corrected for stage at presentation [10]. Previously, suggestions had been made that any difference in clinical outcomes between mucinous and nonmucinous carcinomas were attributed to a more advanced stage at presentation.…”

Section: Clinical Outcomes and Survivalmentioning

confidence: 99%

“…One of the largest studies examining the outcomes of mucinous tumours investigated 16,991 patients and found that just over 18 % of all mucinous tumours were found in the rectum compared with 29 % of non-mucinous tumours [9]. A recent meta-analysis of outcomes in mucinous colon cancer, which included some studies with rectal tumours, reported that mucinous tumours were more frequently found proximal to the splenic flexure compared to non-mucinous adenocarcinoma [10]. Conversely, mucinous tumours are more common than non-mucinous in the proximal colon.…”

Section: Epidemiology and Clinical Characteristicsmentioning

confidence: 99%

Mucinous carcinoma of the rectum: a distinct clinicopathological entity

Chand

Swift

et al. 2013

Tech Coloproctol

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Purpose The definition of mucinous tumours relies on quantification of the amount of mucus produced by neoplastic cells within the rectum. This has changed over the years to include varying degrees of mucin production. The inconsistency of diagnosis has led to conflicting reports in the literature regarding clinical outcomes and treatment response. A universally accepted definition and improved imaging and surgical techniques in the last decade are now challenging the traditional view of these tumours. The aim of this review was to present the current evidence on the clinicopathological characteristics of mucinous tumours of the rectum. Methods A systematic review was conducted using Preferred Reporting for Systematic Reviews and Meta-Analyses guidelines. A literature search was performed using the Ovid SP to search both EMBASE and MEDLINE databases, Google Scholar and PubMed to find all studies relating to mucinous carcinoma of the rectum. The search dates were between 1 January 1965 and 1 March 2013. Results Mucinous tumours comprise 5-20 % of all rectal cancers and commonly present at a more advanced stage and in younger patients. They are readily identified on MRI, and the diagnosis is confirmed on histological analysis, demonstrating more than 50 % of extracellular mucin within the tumour complex. They carry an overall worse prognosis compared to adenocarcinoma of the same stage. The response to oncological treatment remains controversial. Conclusion Mucinous tumours of the rectum are less well understood than non-mucinous adenocarcinoma. This is due to the inconsistent histopathological definitions of the past making comparison of clinical outcome data difficult. They remain challenging to treat and are associated with a poor prognosis. A universally accepted definition and the role of imaging techniques such as MRI to accurately detect mucinous tumours are likely to lead to a better understanding of these cancers.

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“…Some studies believed that mucinous histologic type itself is an important prognostic factor affecting the progression of tumor and outcome of patients with colorectal carcinoma. And the survival rate of patients with mucinous adenocarcinoma could be inferior to the patients with non-mucinous adenocarcinoma (NMC) (Kanemitsu et al, 2003;Verhulst et al, 2012;Biffi et al, 2013;Hugen et al, 2013), while some other studies did not find any adverse prognostic effect (Leopoldo et al, 2007;Farhat et al, 2008;Xie et al, 2009;Langner et al, 2012;Yamaguchi et al, 2012).…”

Section: Rectal Carcinoma Patientsmentioning

confidence: 99%

Prognostic Significance of the Mucin Component in Stage III Rectal Carcinoma Patients

Wang¹,

Zhang²,

Yang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Mucinous subtype as prognostic factor in colorectal cancer: a systematic review and meta-analysis

Cited by 228 publications

References 72 publications

Factors associated with short recurrence-free survival in completely resected colon cancer

Factors associated with short recurrence-free survival in completely resected colon cancer

Mucinous carcinoma of the rectum: a distinct clinicopathological entity

Prognostic Significance of the Mucin Component in Stage III Rectal Carcinoma Patients

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