Prognostic significance of mean platelet volume in diabetic patients with ST-elevation myocardial infarction

Lekston, Andrzej; Hudzik, Bartosz; Hawranek, Michał; Szkodziński, Janusz; Gorol, Jarosław; Wilczek, Krzysztof; Gąsior, Mariusz; Poloński, Lech

doi:10.1016/j.jdiacomp.2014.05.002

Cited by 25 publications

(21 citation statements)

References 33 publications

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“…30) Although the pooled analysis of four ISAR trials 19) and a subgroup analysis of the CADILLAC trial 18) confirmed that a higher baseline PC was a predictor of adverse prognosis in patients undergoing PCI, other studies found no significant association between baseline PC and adverse prognosis in patients with STEMI undergoing PCI. [11][12][13][14]22) Our study confirmed again that high MPV was an independent predictor of adverse prognosis for patients with STEMI undergoing P-PCI, but high PC was not.…”

Section: Mpv/pc Ratio Predicate Prognosis In Stemisupporting

confidence: 67%

“…15) They noted that MPV was a strong, independent predictor of impaired angiographic reperfusion and 6-month mortality in patients with STEMI undergoing PCI. 15) This observation has since been confirmed by several other studies [10][11][12][13][14]16,17) and has been extended by the observation that elevated MPV at admission was an independent predictor of large intracoronary thrombus burden.…”

Section: Mpv/pc Ratio Predicate Prognosis In Stemimentioning

confidence: 55%

“…6,8) Increased MPV was confirmed to be related with coronary artery disease (CAD). 9) Further, recent researches have shown that increased MPV was associated with a worse short-term [10][11][12][13][14] and long-term 11,[15][16][17] prognosis, as well as angiographic thrombus burden 13) and impaired myocardial reperfusion 12,14,15) in patients with STEMI undergoing P-PCI. And platelet count (PC) has been determined as an important predictor of adverse events in patients with CAD undergoing PCI.…”

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confidence: 99%

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Predictive Value of Mean Platelet Volume/Platelet Count for Prognosis in Acute Myocardial Infarction

Tian

Song

et al. 2018

Int. Heart J.

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SummaryIncreased mean platelet volume (MPV) has been associated with adverse clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI). We aim to assess whether MPV/platelet count (MPV/PC) ratio is a useful marker to predict long-term prognosis in patients with STEMI undergoing PCI. Moreover, the prognostic accuracy of MPV/PC ratio is compared with MPV. 962 consecutive patients with STEMI treated with P-PCI were considered. According to the admission MPV/PC values, the population was divided into two groups: high MPV/PC group (n = 320, MPV/PC !0.055) and low MPV/PC group (n = 642, MPV/PC < 0.055). Multivariate analysis showed that high MPV/PC was an independent predictor of major adverse cardiovascular event (MACE; hazard ratio [HR]: 1.121, 95% confidence interval [CI]: 1.056-1.190, P < 0.01), all-cause mortality (HR: 1.109, 95% CI: 1.016-1.209, P = 0.020), cardiac mortality (HR: 1.141, 95% CI: 1.038-1.253, P = 0.006), nonfatal myocardial reinfarction (HR: 1.148, 95% CI: 1.044-1.262, P = 0.004), and unplanned repeat revascularization (HR: 1.073, 95% CI: 1.007-1.144, P = 0.030), respectively. MPV/PC ratio has good accuracy for predicting MACE (the area under the receiver-operating characteristic curve: 0.764), and the cut-off value was 0.054 with a sensitivity of 0.813 and a specificity of 0.662. The discriminatory performance of MPV/PC ratio was better than MPV for predicting MACE (MPV/PC ratio versus MPV: z = 2.285, P = 0.022), in patients with STEMI undergoing P-PCI. MPV/PC ratio is able to but better than MPV to predict long-term adverse outcomes in patients with STEMI undergoing P-PCI.(Int Heart J Advance Publication)

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Section: Mpv/pc Ratio Predicate Prognosis In Stemisupporting

confidence: 67%

Section: Mpv/pc Ratio Predicate Prognosis In Stemimentioning

confidence: 55%

mentioning

confidence: 99%

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Predictive Value of Mean Platelet Volume/Platelet Count for Prognosis in Acute Myocardial Infarction

Tian

Song

et al. 2018

Int. Heart J.

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“…Platelets of patients with DM are characterized by dysregulation of several signaling pathways, resulting in increased platelet reactivity [6]. Increased platelet size and activity may play a role in the observed higher risk for developing ST-segment elevation myocardial infarction (STEMI) and worse outcomes in patients with DM [7].…”

Section: Introductionmentioning

confidence: 99%

“…MPV is an important factor for helping predict the prognosis of patients with CAD [6,[11][12][13]. Few studies have examined MPV in patients with stable CAD (SCAD) and DM.…”

Section: Introductionmentioning

confidence: 99%

Two-year prognostic value of mean platelet volume in patients with diabetes and stable coronary artery disease undergoing elective percutaneous coronary intervention

Jiang

Song

et al. 2013

Cardiol J.

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Background: Mean platelet volume (MPV) is a marker of platelet size and activity, and is associated with a poor prognosis of cardiovascular disease. Studies have shown a relationship between diabetes mellitus (DM) and MPV. This study examined the relationship between admission MPV and 2-year cardiac mortality in patients with DM and stable coronary artery disease (SCAD) undergoing elective percutaneous coronary intervention (PCI). Methods: A total of 1389 patients were enrolled and divided into two groups according to MPV as follows: lower MPV (n = 908, MPV ≤ 10.9 fL) and higher MPV (n = 481, MPV > 10.9 fL . Receiver operating characteristic analysis showed a good diagnostic value for MPV at predicting long-term cardiac mortality (area under the curve: 0.735, p = 0.01). Elevated MPV was a significant risk factor for 2-year cardiac mortality (hazard ratio: 2.091, p = 0.030) in multivariable Cox regression analysis. Conclusions: Mean platelet volume is a strong, independent prognostic factor in PCI-treated patients with DM and SCAD. (Cardiol J 2019; 26, 2: 138-146)

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Platelet mean volume, distribution width, and count in type 2 diabetes, impaired fasting glucose, and metabolic syndrome: a meta‐analysis

Zaccardi

Rocca²,

Pitocco

et al. 2014

Diabetes Metabolism Res

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Prognostic significance of mean platelet volume in diabetic patients with ST-elevation myocardial infarction

Cited by 25 publications

References 33 publications

Predictive Value of Mean Platelet Volume/Platelet Count for Prognosis in Acute Myocardial Infarction

Predictive Value of Mean Platelet Volume/Platelet Count for Prognosis in Acute Myocardial Infarction

Two-year prognostic value of mean platelet volume in patients with diabetes and stable coronary artery disease undergoing elective percutaneous coronary intervention

Platelet mean volume, distribution width, and count in type 2 diabetes, impaired fasting glucose, and metabolic syndrome: a meta‐analysis

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