Prognostic Significance of Low Body Mass Index and Betel-Quid Use in the 5-Year Survival Rates of Esophageal Squamous Cell Carcinoma Patients

Pan, Yu‐Hwa; Hsu, Ting-You; Lin, Jui-Ying; Ho, Chia-Jung; Kuan, Chiung-Ying; Chou, Wen‐Chi; Lai, Cheng‐Hung; Chang, Pei‐Hung; Yeh, Kun‐Yun

doi:10.1080/01635581.2019.1588983

Cited by 10 publications

(7 citation statements)

References 34 publications

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“…Mounting evidence has demonstrated that inflammatory and nutritional indices are significantly associated with clinicopathological parameters and prognosis in EC patients ( 3 , 4 , 9 , 10 ). Given the above, retrospective analysis to determine associations between pre-therapeutic inflammatory and nutritional indices and survival outcomes in patients with ESCC who received dCRT was performed.…”

Section: Discussionmentioning

confidence: 99%

“…There is still no consensus about the most useful and best nutritional index for the prognostic evaluation of patients with locally advanced ESCC who are treated with dCRT. Previous studies have demonstrated BMI to be useful for predicting survival outcomes of patients with some cancers ( 11 – 13 ), including ESCC ( 3 , 4 ). However, EC is a type of tumor entity in which being overweight is rare ( 4 , 27 ).…”

Section: Discussionmentioning

confidence: 99%

“…Body mass index (BMI) is a risk factor for EC ( 3 , 4 ). Previous studies have indicated that BMI can potentially represent comprehensive information on body composition status, especially in cancer patients ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

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A Nutrition-Related Factor-Based Risk Stratification for Exploring the Clinical Benefits in the Treatment of Patients With Locally Advanced Esophageal Squamous Cell Carcinoma Receiving Definitive Chemoradiotherapy: A Retrospective Cohort Study

Qiu

et al. 2022

Front. Nutr.

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ObjectiveNo study has reported the risk stratification of BMI and PNI in patients with locally advanced esophageal squamous cell carcinoma (ESCC) undergoing definitive chemoradiotherapy (dCRT). This study aimed to construct a risk stratification to guide the treatment of ESCC following dCRT.MethodsA total of 1,068 patients with locally advanced ESCC who received dCRT were retrospectively analyzed. The impacts of clinicopathological factors on overall survival (OS) and progression-free survival (PFS) were analyzed. Besides, the novel prognostic indices of pre-therapeutic nutritional index (PTNI) and prognostic index (PI) were developed.ResultsThe median follow-up period of OS and PFS were 22.9 and 17.4 months, respectively. The high body mass index (BMI) group had better 5-year OS and PFS (36.4 and 34.0%) than the low BMI group (18.8 and 17.2%). The high prognostic nutritional index (PNI) group also had better 5-year OS and PFS (33.4 and 30.9%) than the low PNI group (17.5 and 17.2%). Multivariate Cox regression analysis showed that BMI and PNI were independent prognostic factors for OS and PFS. Based on nutritional indices, patients were categorized into the low-risk (PTNI = 1), medium-risk (PTNI = 2), and high-risk (PTNI = 3) groups with 5-year OS rates of 38.5, 18.9, 17.5%, respectively (p < 0.001) and 5-year PFS rates of 35.8, 17.6, 16.8%, respectively (p < 0.001). Besides, we also constructed a prognostic index (PI) for OS and PFS which was calculated based on statistically significant factors for predicting OS and PFS. The results revealed that the high-risk group had worse OS and PFS than the low-risk group (p < 0.001). Finally, RCS analysis demonstrated a non-linear relationship between the PNI, BMI, and survival for patients with ESCC. The death hazard of PNI and BMI sharply decreased to 41.8 and 19.7.ConclusionThe decreased pre-therapeutic BMI and PNI levels were associated with a worse survival outcome. BMI and PNI are readily available and can be used to stratify risk factors for locally advanced ESCC patients undergoing dCRT. The novel risk stratification may help to evaluate patients’ pre-therapeutic status and guide dCRT for locally advanced ESCC patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Nutrition-Related Factor-Based Risk Stratification for Exploring the Clinical Benefits in the Treatment of Patients With Locally Advanced Esophageal Squamous Cell Carcinoma Receiving Definitive Chemoradiotherapy: A Retrospective Cohort Study

Qiu

et al. 2022

Front. Nutr.

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“…Moreover, there were several studies indicated that PNI was not an independent factor for prognosis in esophageal cancer. 18,25 Sun et al 18 conducted a retrospective study including 502 esophageal cancer patients and found low PNI was associated with poor OS, but it did not display reliably as an independent predictor. Pan et al 25 estimated the relationship between various varied malnutrition criteria and survival in cell ESCC patients, and concluded that low BMI but not PNI at diagnosis was an independent prognostic factor for worse survival of ESCC patients.…”

mentioning

confidence: 99%

“…18,25 Sun et al 18 conducted a retrospective study including 502 esophageal cancer patients and found low PNI was associated with poor OS, but it did not display reliably as an independent predictor. Pan et al 25 estimated the relationship between various varied malnutrition criteria and survival in cell ESCC patients, and concluded that low BMI but not PNI at diagnosis was an independent prognostic factor for worse survival of ESCC patients. As the PNI represents nutrition and immune status, but Alb and Hb did not show significant prognostic effect.…”

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confidence: 99%

Prognostic Significance of Preoperative Prognostic Nutritional Index for Overall Survival and Postoperative Complications in Esophageal Cancer Patients

Qi¹,

Song²,

Cheng³

et al. 2021

CMAR

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Risk prediction of esophageal squamous cell carcinoma recurrence in patients who underwent esophagectomy after receiving neoadjuvant treatment: a nationwide retrospective study in Japan

et al. 2023

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Prognostic Significance of Low Body Mass Index and Betel-Quid Use in the 5-Year Survival Rates of Esophageal Squamous Cell Carcinoma Patients

Cited by 10 publications

References 34 publications

A Nutrition-Related Factor-Based Risk Stratification for Exploring the Clinical Benefits in the Treatment of Patients With Locally Advanced Esophageal Squamous Cell Carcinoma Receiving Definitive Chemoradiotherapy: A Retrospective Cohort Study

A Nutrition-Related Factor-Based Risk Stratification for Exploring the Clinical Benefits in the Treatment of Patients With Locally Advanced Esophageal Squamous Cell Carcinoma Receiving Definitive Chemoradiotherapy: A Retrospective Cohort Study

Prognostic Significance of Preoperative Prognostic Nutritional Index for Overall Survival and Postoperative Complications in Esophageal Cancer Patients

Risk prediction of esophageal squamous cell carcinoma recurrence in patients who underwent esophagectomy after receiving neoadjuvant treatment: a nationwide retrospective study in Japan

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