Prognostic Significance of Preoperative Prognostic Nutritional Index for Overall Survival and Postoperative Complications in Esophageal Cancer Patients

Qi, Qingqing; Song, Qingxu; Cheng, Yufeng; Wang, Nana

doi:10.2147/cmar.s333190

Cited by 30 publications

(25 citation statements)

References 35 publications

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“…PNI was developed to assess the preoperative nutritional immune status and postoperative complications in surgical patients and has since been demonstrated to be a reliable prognostic factor for numerous malignancies, such as gastric cancer [ 16 ], intrahepatic cholangiocarcinoma [ 29 ], esophageal cancer [ 30 ], and nasopharyngeal carcinoma [ 31 ]. In the field of sepsis, Wu et al reported that after adjusting for confounding variables, PNI was asserted to be an independent prognostic factor for all-cause mortality at 30 days [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Value of Prognostic Nutritional Index and Neutrophil-to-Lymphocyte Ratio in Prediction of the Development of Sepsis-Induced Kidney Injury

et al. 2022

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Background. Sepsis-related acute kidney injury (S-AKI) is a frequent complication of hospitalized patients and is linked to increased morbidity and mortality. Early prediction and detection remain conducive to optimizing treatment strategies and limiting further insults. This study was aimed at evaluating the potential predictive value of the combined prognostic nutrition index (PNI) and neutrophil-to-lymphocyte ratio (NLR) to predict the risk of AKI in septic patients. Methods. In this retrospective study, 1238 adult patients with sepsis who were admitted to the First Affiliated Hospital of Xi’an Jiaotong University from January 2015 to June 2021 were enrolled. Patients were divided into two groups: the non-AKI group ( n = 731 ) and the S-AKI group ( n = 507 ). Univariate and multivariate logistic regression analyses were performed to screen the independent predictive factors of S-AKI. A receiver operating characteristic (ROC) curve was used to evaluate the predictive value of PNI and NLR. Results. Multivariate logistic regression analysis indicated that age, chronic liver disease, cardiovascular disease, respiratory rate (RR), white blood cells (WBC), blood urea nitrogen (BUN), creatinine (CRE), international normalized ratio (INR), neutrophil-to-lymphocyte ratio (NLR), and prognostic nutrition index (PNI) were independent prognostic factors of S-AKI. In the three models, the adjusted OR of PNI for S-AKI was 0.802 (0.776-0.829), 0.801 (0.775-0.829), and 0.717 (0.666-0.772), while that of NLR was 1.094 (1.078-1.111), 1.097 (1.080-1.114), and 1.044 (1.016-1.072), respectively. In addition, the area under the ROC curve of the PNI plus NLR group was significantly greater than that of the CRE plus BUN group (0.801, 95% CI: 0.775-0.827 vs. 0.750, 95% CI: 0.722-0.778, respectively; P < 0.001 ). Conclusions. PNI and NLR have been identified as readily available and independent predictors in septic patients with S-AKI. PNI, in combination with NLR, is of vital significance for early warning and efficient intervention of S-AKI and is superior to combined BUN and CRE.

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Section: Discussionmentioning

confidence: 99%

Clinical Value of Prognostic Nutritional Index and Neutrophil-to-Lymphocyte Ratio in Prediction of the Development of Sepsis-Induced Kidney Injury

et al. 2022

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“…Eight studies involving 3,267 patients explored the relationship between SII and OS (23,(25)(26)(27)(28)(29)(30)(31). The pooled…”

Section: The Association Between Sii and Os Of Esophageal Cancer Pati...mentioning

confidence: 99%

The prognostic value of systemic immune-inflammation index in surgical esophageal cancer patients: An updated meta-analysis

Zhang

Lü

et al. 2022

Front. Surg.

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PurposeTo identify the prognostic role of systemic immune-inflammation index (SII) in esophageal cancer patients receiving operation.MethodsThe PubMed, EMBASE, Web of Science, Cochrane Library, WanFang and CNKI electronic databases were searched up to February 17, 2022 for relevant studies. The hazard ratios (HRs) and 95% confidence intervals (CIs) were combined to assess the association between SII and prognosis in surgical esophageal cancer patients. The primary outcome was overall survival (OS) and secondary outcomes were progression-free survival (PFS) and cancer-specific survival (CSS). All statistical analyses were conducted by STATA 15.0 software.ResultsA total of nine retrospective studies involving 3,565 participates were included. The pooled results indicated that high SII was significantly related with poor OS (HR = 1.58, 95% CI: 1.23–2.02, P < 0.001). However, subgroup analysis based on pathological type demonstrated that high SII was an independent predictor for poor OS only in esophageal squamous cell carcinoma (ESCC) patients (HR = 1.72, 95% CI: 1.34–2.21, P < 0.001). Besides, SII was also significantly associated with poor PFS (HR = 1.94, 95% CI: 1.61–2.35, P < 0.001) and CSS (HR = 1.44, 95% CI: 1.04–1.99, P = 0.027) in ESCC patients.ConclusionThe SII could serve as an independent prognostic factor in surgical ESCC patients and higher SII was related with worse survival. However, more prospective high-quality studies are still needed to verify above findings.

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“…Intraoperative transfusion was recorded in 15 patients (9.9%). The median LOS after operation was 17 days (IQR, [12][13][14][15][16][17][18][19][20][21][22][23][24][25]. The detailed baseline characteristics and perioperative data were showed in Table 1.…”

Section: Baseline Characteristics and Perioperative Datamentioning

confidence: 99%

The predictive value of prognostic nutritional index on early complications after robot-assisted radical cystectomy

Wang

Gao²,

Liu³

et al. 2022

Front. Surg.

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ObjectiveThe purpose of the study was to evaluate the predictive value of prognostic nutritional index (PNI) on early complications (within 30-day) after robot-assisted radical cystectomy (RARC) and urinary diversion.Patients and methodsPatients underwent RARC and urinary diversion between November 2018 and December 2021 in our centre were screened in this retrospective study. Baseline characteristics and perioperative data were recorded. Early complications after surgery were classified according to Clavien-Dindo system. Univariate and multivariate logistic analysis were performed to decide the potential factors associated with post-RARC complications. The receiver operating characteristic (ROC) curve was conducted to determine the predictive value of PNI on early overall and major complications after RARC.ResultsOverall 139 men and 13 women with a median age of 69 years and mean BMI of 24.4 kg/m2 were included in this study. As for urinary diversion, most patients (n = 111, 73%) received cutaneous ureterostomy, 36 patients (23.7%) underwent orthotopic neobladder and 5 patients (3.3%) received ileal conduit. The incidence of postoperative complication rate was 44.7%, which included 82.2% minor complications and 17.8% major complications. Further univariate and multivariate logistic analyses demonstrated that hypertension (OR = 2.96, 95% CI: 1.24–7.07, P = 0.015), PNI (OR = 0.73, 95% CI: 0.62–0.86, P < 0.001), and CCI (OR = 1.44, 95% CI: 1.01–2.06, P = 0.047) were independent risk factors of early complications after RARC. Moreover, PNI (OR = 0.72, 95% CI: 0.60–0.86, P < 0.001) was also the predictor of major complications after RARC. The ROC curve demonstrated that PNI (AUC = 0.829; AUC = 0.840) has a great predictive value in early overall and major complications after RARC.ConclusionPNI can be an early alert for RARC patients thus aiding in closer monitoring and postoperative management.

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Prognostic Significance of Preoperative Prognostic Nutritional Index for Overall Survival and Postoperative Complications in Esophageal Cancer Patients

Cited by 30 publications

References 35 publications

Clinical Value of Prognostic Nutritional Index and Neutrophil-to-Lymphocyte Ratio in Prediction of the Development of Sepsis-Induced Kidney Injury

Clinical Value of Prognostic Nutritional Index and Neutrophil-to-Lymphocyte Ratio in Prediction of the Development of Sepsis-Induced Kidney Injury

The prognostic value of systemic immune-inflammation index in surgical esophageal cancer patients: An updated meta-analysis

The predictive value of prognostic nutritional index on early complications after robot-assisted radical cystectomy

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