Prognostic Significance of EGFR and p53 Expression, and Angiogenesis in Laryngeal Squamous Cell Carcinoma.

Watanabe, Hidehiko; Suzuki, Tomoo; Ito, Yatsuji; Mizuta, Keisuke; Sawai, Shigeo; Miyata, Hideo

doi:10.3950/jibiinkoka.102.243

Cited by 5 publications

(3 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…33 Watanabe et al found EGFR status to be an independent predictor of local recurrence-free survival but only in patients with T2, T3, or T4 laryngeal neoplasms. 34 Recent randomized clinical trials combining C225 anti-EGFR antibodies (Cetuximab) with radiotherapy have shown promising locoregional control and reduction in mortality for locally advanced HNSCC. 35 In the current study, other molecular markers such as EGFR and p53 did not correlate with local relapse or overall survival.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of vascular endothelial growth factor protein levels in T1‐2 N0 laryngeal cancer treated with primary radiation therapy

Yang¹,

Haffty²

2006

Cancer

View full text Add to dashboard Cite

BACKGROUND.The purpose of this study was to assess the prognostic value of vascular endothelial growth factor protein levels in a large cohort of patients with T1‐T2 N0 laryngeal cancer treated with primary radiation therapy (XRT).METHODS.Primary tumor specimens from a cohort of 123 patients with T1‐T2 N0 laryngeal cancer treated with XRT between 1975 and 2000 were constructed into a tissue microarray. Clinical prognostic factors included age, sex, T classification, and tumor subsite. Molecular prognostic factors included vascular endothelial growth factor, epidermal growth factor receptor, and p53 expression, determined by using immunohistochemistry on tissue microarrays. The association between vascular endothelial growth factor status, covariables, and outcome was assessed.RESULTS.With a median follow‐up of 9.9 years, 32 (26%) were diagnosed with local relapse (5‐year local relapse‐free rate, 70.4%). T2 tumor stage (31.7%) was a significant predictor of local relapse (relative risk [RR], 1.71; 95% confidence interval [CI], 1.21–2.43; P<.05). Positive expression of vascular endothelial growth factor, epidermal growth factor receptor, and p53 were: 8.5%, 58.7%, and 36.4%, respectively. In univariate analysis, vascular endothelial growth factor positivity was a significant predictor of overall survival (RR = 1.62; 95% CI, 0.99–2.42; P = .05). In multivariate analysis, positive vascular endothelial growth factor status maintained significant correlation with overall survival (RR, 2.79; 95% CI, 1.49–4.95; P = .002).CONCLUSIONS.Vascular endothelial growth factor positivity appeared to be a significant predictor of overall survival in a multivariate model. Further evaluation of vascular endothelial growth factor‐positive laryngeal cancers treated with primary XRT is warranted. Cancer 2007;109:566–573. © 2006 American Cancer Society.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic significance of vascular endothelial growth factor protein levels in T1‐2 N0 laryngeal cancer treated with primary radiation therapy

Yang¹,

Haffty²

2006

Cancer

View full text Add to dashboard Cite

show abstract

“…It has been shown that the overexpressed receptors correlate with more advanced tumors, poor survival, and higher risk of lymph node metastasis. (Rafferty et al 2001;Takes et al 2001;Ling et al 2000;Gale et al 2000;Watanabe et al 1999;Almadori et al 1999;Maurizi et al 1996).…”

Section: Introductionmentioning

confidence: 97%

Tissue microarray analysis of EGFR and HER2 oncogene copy number alterations in squamous cell carcinoma of the larynx

Koynova

Tsenova

Jankova

et al. 2004

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

show abstract

“…Specifically, HER1 (epidermal growth factor receptor [EGFR]) is a relevant player in head and neck squamous cell carcinogenesis, as it is expressed in over 90% of head and neck squamous cell carcinomas (SCCs), and overexpression of EGFR correlates with more advanced tumors, poor survival, and higher risk of lymph node metastasis 8–14. Data about the other members of the HER family (HER2, 3, 4) in head and neck SCC are less definite and sometimes contradictory 15–22.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical expression patterns of the HER4 receptors in normal mucosa and in laryngeal squamous cell carcinomas: Antioncogenic significance of the HER4 protein in laryngeal squamous cell carcinoma

et al. 2012

View full text Add to dashboard Cite

The choice of postremission therapy for acute myeloid leukemia (AML) patients is now based on the blasts' cytogenetic and molecular profile. However, the potential benefit of autologous hematopoietic stem cell transplantation (auto‐HSCT) according to the NPM1/FLT3‐ITD status has been poorly studied in AML patients with a normal karyotype (NK). Therefore, we evaluated the NPM1/FLT3‐ITD molecular status in 135 NK‐AML patients treated by allogeneic HSCT (allo‐HSCT), auto‐HSCT, or chemotherapy as consolidation therapy within the GOELAMS LAM‐2001 trial. In univariate analyzes, 4‐year leukemia‐free survival (LFS) and overall survival (OS) were significantly higher for NPM1+/FLT3‐ITD− patients compared with patients presenting another molecular profile (61 vs. 43% and 72 vs. 48%, P = 0.02 and P = 0.01, respectively). In the NPM1+/FLT3‐ITD− subgroup, there was no benefit for allo‐HSCT or auto‐HSCT vs. chemotherapy (4‐year LFS: 71, 56, and 60%; 4‐year OS: 73, 71, and 60%, respectively; P = NS). For patients with other NPM1/FLT3‐ITD molecular profiles, allo‐HSCT was found to be the best consolidation therapy, whereas auto‐HSCT was associated with a better outcome when compared with chemotherapy (allo‐HSCT‐, auto‐HSCT‐, and chemotherapy‐related 4‐year LFS: 68, 44, and 36%, P = 0.004; 4‐year OS: 68, 52, and 29%, respectively, P = 0.02). Our study indicates that allo‐HSCT and auto‐HSCT provide similar outcomes compared with chemotherapy as consolidation for NPM1+/FLT3‐ITD− NK‐AML patients. For NK‐AML patients with an adverse molecular profile, auto‐HSCT could represent an alternative therapeutic approach when no human leukocyte antigen–matched allogeneic donor is available. Am. J. Hematol. 2012. © 2012 Wiley Periodicals, Inc.

show abstract

Prognostic Significance of EGFR and p53 Expression, and Angiogenesis in Laryngeal Squamous Cell Carcinoma.

Cited by 5 publications

References 37 publications

Prognostic significance of vascular endothelial growth factor protein levels in T1‐2 N0 laryngeal cancer treated with primary radiation therapy

Prognostic significance of vascular endothelial growth factor protein levels in T1‐2 N0 laryngeal cancer treated with primary radiation therapy

Tissue microarray analysis of EGFR and HER2 oncogene copy number alterations in squamous cell carcinoma of the larynx

Immunohistochemical expression patterns of the HER4 receptors in normal mucosa and in laryngeal squamous cell carcinomas: Antioncogenic significance of the HER4 protein in laryngeal squamous cell carcinoma

Contact Info

Product

Resources

About