These results suggest that EGFR amplification is a relatively rare event in larynx carcinogenesis that obviously does not predispose to tumor progression.
Colorectal cancer is one of the most common neoplastic
diseases and a leading cause of cancer-related deaths.
Overexpression of epidermal growth factor receptor
(EGFR) is commonly associated with this cancer. The aim
of our study was to determine the frequency of epidermal
growth factor receptor gene amplification and gain
in a large number of colorectal carcinomas, arranged in a
tissue microarray, in order to assess their role in colorectal
cancer development. A tissue microarray of 498 patients
with colorectal tumors was constructed, and 239
samples for EGFR copy number changes were successfully
analyzed by fluorescence in situ hybridization. No
amplification of EGFR was detected in our cohort of patients
with colorectal tumors, and the EGFR gene was
upregulated in only 2 tumors (0.84%). Therefore, the development
of colon cancer in patients cannot be explained
by copy number changes of the EGFR gene.
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