Prognostic Significance of Diabetes Mellitus in Locally Advanced Non-small Cell Lung Cancer

Imai, Hisao

doi:10.2974/kmj.67.87

Cited by 8 publications

(15 citation statements)

References 36 publications

(62 reference statements)

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“…Type 1 DM (T1DM) and type 2 (T2DM) were not differentiated in these publications. Four studies were from Asia [17][18][19][20] and 13 were from western countries. [21][22][23][24][25][26][27][28][29][30][31][32][33] Most studies were published within the last 10 years and the sample sizes ranged from 146 to 10378.…”

Section: Study Description and Quality Assessmentmentioning

confidence: 99%

“…[21][22][23][24][25][26][27][28][29][30][31][32][33] Most studies were published within the last 10 years and the sample sizes ranged from 146 to 10378. Seven of the studies 17,19,24,25,27,29,31) investigated the outcomes of patients undergoing surgical treatment, while six studies 18,21,23,26,30,33) focused on those receiving non-surgical treatments like chemotherapy or radiotherapy and three studies 20,22,32) recruited patients receiving both of them. All but one study were retrospective cohort studies while the only exception was designed as a prospective cohort.…”

Section: Study Description and Quality Assessmentmentioning

confidence: 99%

“…All but one study were retrospective cohort studies while the only exception was designed as a prospective cohort. 31) In all, 13 of the studies [17][18][19][20][24][25][26][27][29][30][31][32][33] ascertained the diagnosis of preexisting DM in reference to medical records or documented use of anti-diabetic drugs, three retrieved the diagnostic information from local registry system. 21,22,28) In total, 13 studies adopted multivariate regression models to calculate HR while four studies chose univariate models.…”

Section: Study Description and Quality Assessmentmentioning

confidence: 99%

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The Effect of Diabetes Mellitus on Prognosis of Patients with Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis

Yao

Bian

et al. 2020

ATCS

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Purpose: To quantitatively evaluate the effect of preexisting diabetes mellitus (DM) on the outcomes of patients with non-small-cell lung cancer (NSCLC). Materials and Methods: Observational studies comparing the prognosis of NSCLC patients with and without diabetes were identified from PubMed, EMBASE, and The Cochrane Central Register of Controlled Trials (CENTRAL). We searched for studies that published in English from inception to March 30, 2019, using search terms related to diabetes and NSCLC. Pooled hazard ratio (HR) and 95% confidence interval (CI) were calculated by a random-effect model and subgroup analyses were performed. Results: In all, 17 of 1475 identified studies were finally included in the meta-analysis. The result revealed that preexisting diabetes had a significantly negative impact on the overall survival (OS) of patients with NSCLC (HR: 1.31, 95% CI: 1.12-1.54), especially in patients undergoing surgical treatment (HR: 1.46, 95% CI: 1.02-2.09) in comparison with those receiving only non-surgical treatment (HR: 1.33, 95% CI: 0.87-2.03). In addition, preexisting diabetes was more likely to be associated with a worse prognosis among Asian NSCLC patients than Western patients. Sensitivity analysis indicated that the main result was robust, and no evidence of publication bias was found. Conclusion: Preexisting DM has a negative impact on diabetic NSCLC patients' prognosis.

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Section: Study Description and Quality Assessmentmentioning

confidence: 99%

Section: Study Description and Quality Assessmentmentioning

confidence: 99%

Section: Study Description and Quality Assessmentmentioning

confidence: 99%

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The Effect of Diabetes Mellitus on Prognosis of Patients with Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis

Yao

Bian

et al. 2020

ATCS

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“…The literature reports that diabetes mellitus has a significant impact on the prognosis of gastric cancer, colorectal cancer, breast cancer and other malignant tumors . However, there are few studies on the impact of diabetes mellitus on lung cancer, and there are differences in their findings . At present, most of the studies on lung cancer with diabetes mellitus are on patients with advanced disease who are receiving chemoradiotherapy, while there are relatively few studies on patients with lung cancer and diabetes mellitus undergoing surgery in the early and middle stages .…”

Section: Discussionmentioning

confidence: 99%

Long‐term survival analysis of patients with non‐small cell lung cancer complicated with type 2 diabetes mellitus

Wang

Xiong

et al. 2020

Thoracic Cancer

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Background: This study aimed to investigate the effect of type 2 diabetes mellitus on survival of patients with non-small cell lung cancer (NSCLC). Methods: We retrospectively analyzed NSCLC patients who had undergone radical lung cancer surgery from January 2011 to December 2014 in the Anhui Medical University affiliated Anhui Provincial Hospital. Kaplan-Meier plots, log-rank tests, and Cox proportional hazards regression models were used to describe the effect of type 2 diabetes mellitus on the overall survival of patients with NSCLC. Results: A total of 769 patients with NSCLC were enrolled, including 126 in the diabetic mellitus group and 643 in the nondiabetic mellitus group. The one, three, and five-year survival for patients with and without diabetes mellitus were 86.1% versus 89.6%, 49.5% versus 62.4%, and 33.3% versus 40.6%, respectively. The Cox model showed that type 2 diabetes mellitus was a poor independent prognostic factors for NSCLC patients. In addition, metformin is a good independent prognostic factor for patients with non-small cell lung cancer with type 2 diabetes mellitus. Conclusions: NSCLC patients without type 2 diabetes mellitus have an increased survival rate compared with those with type 2 diabetes mellitus. Methods Sample setting and study populationThis retrospective study was conducted with approval of the Institutional Review

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“…Type 1 diabetes is regarded to be associated with an increased risk of lung cancer [84], despite several conflicting retrospective studies on lung cancer prognosis among diabetic patients [85,86]. On the basis of two large cohorts from Shanghai, it was reported that the risk of lung cancer was observed in both men and women, with a HR of 0.87 and 0.92, respectively [87].…”

Section: Epidemiologymentioning

confidence: 99%

Diabetes and Lung Disease: A Neglected Relationship

Khateeb¹,

Fuchs²,

Khamaisi³

2018

Rev Diabet Stud

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BACKGROUND: Diabetes mellitus is a systemic disorder associated with inflammation and oxidative stress which may target many organs such as the kidney, retina, and the vascular system. The pathophysiology, mechanisms, and consequences of diabetes on these organs have been studied widely. However, no work has been done on the concept of the lung as a target organ for diabetes and its implications for lung diseases. AIM: In this review, we aimed to investigate the effects of diabetes and hypoglycemic agent on lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis, pulmonary hypertension, and lung cancer. We also reviewed the potential mechanisms by which these effects may affect lung disease patients. RESULTS: Our results suggest that diabetes can affect the severity and clinical course of several lung diseases. CONCLUSIONS: Although the diabetes-lung association is epidemiologically and clinically well-established, especially in asthma, the underlying mechanism and pathophysiology are not been fully understood. Several mechanisms have been suggested, mainly associated with the proinflammatory and proliferative properties of diabetes, but also in relation to micro-and macrovascular effects of diabetes on the pulmonary vasculature. Also, hypoglycemic drugs may influence lung diseases in different ways. For example, metformin was considered a potential therapeutic agent in lung diseases, while insulin was shown to exacerbate lung diseases; this suggests that their effects extend beyond their hypoglycemic properties.

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Prognostic Significance of Diabetes Mellitus in Locally Advanced Non-small Cell Lung Cancer

Abstract: Background: To investigate the prognostic significance of patient characteristics and clinical laboratory test results in locally advanced non-small cell lung cancer (NSCLC), and in particular the impact of diabetes mellitus (DM) on the survival of patients who underwent chemoradiotherapy.

Cited by 8 publications

References 36 publications

The Effect of Diabetes Mellitus on Prognosis of Patients with Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis

The Effect of Diabetes Mellitus on Prognosis of Patients with Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis

Long‐term survival analysis of patients with non‐small cell lung cancer complicated with type 2 diabetes mellitus

Diabetes and Lung Disease: A Neglected Relationship

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