The Effect of Diabetes Mellitus on Prognosis of Patients with Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis

Bi, Guoshu; Yao, Guangyu; Bian, Yunyi; Li, Xue; Zhang, Yi; Lu, Tao; Fan, Hong

doi:10.5761/atcs.ra.19-00170

Cited by 25 publications

(21 citation statements)

References 47 publications

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“…Significant overlap occurs between symptoms of these diseases and lung cancer, including cough, dyspnea and chest tightness [44]. Another common comorbidity, unrelated to tobacco use, was diabetes, sharing the same risk factors with lung cancer, such as age, diet and smoking [36,45]. Our findings highlight the most prevalent comorbidities among lung cancer patients and the pattern of correlations between the most common comorbidities.…”

Section: Discussionmentioning

confidence: 69%

The role of multimorbidity in short-term mortality of lung cancer patients in Spain: a population-based cohort study

et al. 2021

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Aim Chronic diseases often occur simultaneously and tend to be associated with adverse health outcomes, but limited research has been undertaken to understand their role in lung cancer mortality. Therefore, this study aims to describe the prevalence and patterns of having one (comorbidity) or ≥ 2 chronic diseases (multimorbidity) among lung cancer patients in Spain, and to examine the association between comorbidity or multimorbidity and short-term mortality risk at six months after cancer diagnosis. Methods In this population-based cohort study, data were drawn from two Spanish population-based cancer registries, Girona and Granada, and electronic health records. We identified 1259 adult lung cancer patients, diagnosed from 1st January 2011 to 31st December 2012. We identified the most common patterns of individual comorbidities and their pairwise correlations. We used a flexible parametric modelling approach to assess the overall short-term mortality risk 6 months after cancer diagnosis by levels of comorbidity after adjusting for age, sex, smoking status, province of residence, surgery, cancer stage, histology, and body mass index. Results We found high prevalence of comorbidity in lung cancer patients, especially among the elderly, men, those diagnosed with advanced-stage tumours, smokers, and obese patients. The most frequent comorbidities were chronic obstructive pulmonary disease (36.6%), diabetes (20.7%) and heart failure (16.8%). The strongest pairwise correlation was the combination of heart failure with renal disease (r = 0.20, p < 0.01), and heart failure with diabetes (r = 0.16, p < 0.01). Patients with either one or two or more comorbidities had 40% higher overall mortality risk than those without comorbidities (aHR for comorbidity: 1.4, 95%CI: 1.1–1.7; aHR for multimorbidity: 1.4, 95%CI: 1.1–1.8), when relevant confounding factors were considered. Conclusions The presence of comorbid diseases, rather than the number of comorbidities, was associated with increasing the risk of short-term lung cancer mortality in Spain. Comorbidity was a consistent and independent predictor of mortality among lung cancer patients, six months after diagnosis. The most common comorbid conditions were age-, obesity- and tobacco-related diseases. Our findings highlight the need to develop targeted preventive interventions and more personalised clinical guidelines to address the needs of lung cancer patients with one or more comorbidities in Spain.

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Section: Discussionmentioning

confidence: 69%

The role of multimorbidity in short-term mortality of lung cancer patients in Spain: a population-based cohort study

et al. 2021

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“…At the level of cysts, 34 out of 61 cysts (55.7%) were in the left lung, and most of the cysts occurred in the left lower lobe (42.6%). This contrasts with studies that found more right lung involvement, most commonly in the right lower lobe, either in studies that excluded giant cysts [ 7 ], or those that included them [ [13] , [14] , [16] , [17] ]. Onal et al [ 7 ] investigated the relation between cyst location and rupture in pediatrics and they excluded patients with multiple cysts in one lung.…”

Section: Discussionmentioning

confidence: 79%

“…According to Usluer et al, giant cysts have a higher tendency for rupture, which is a dangerous complication and can lead to anaphylaxis or suffocation [ 4 , 12 ]. Giant cysts usually result from delayed diagnosis or treatment [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Rupture of pulmonary hydatid cyst in pediatrics: A cross-sectional study

Hamouri

Odat

Syaj

et al. 2021

Annals of Medicine and Surgery

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“…Finally, it is important to discuss the role of comorbid diabetes where RAGE expression is increased (Kay et al, 2016) and its impact on cancer outcomes. In non-small cell lung cancer, patients with comorbid diabetes experience lower survival rates (Bi et al, 2020) and poorer outcomes following lung resection (Komatsu et al, 2020). These observations appear consistent across a variety of cancers.…”

Section: Discussionmentioning

confidence: 99%

Analysis of RAGE Proteome and Interactome in Lung Adenocarcinoma Using PANTHER and STRING Databases

Downs

2021

Biological Research For Nursing

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Adenocarcinoma accounts for about 40% of all lung cancers. Histological studies indicate a loss of expression of the Receptor for Advanced Glycation End-products (RAGE) in lung adenocarcinoma cells compared to neighboring non-malignant tissue. Gene silencing of RAGE in human lung adenocarcinoma cells was performed and then cells were subjected to LC-MS/MS ( n = 3, FDR < 1%). Differentially expressed proteins were analyzed using the PANTHER Classification System and STRING Interactome, identifying functions and protein-protein interaction networks. We observed expression of dominant-negative (DN−) RAGE, an isoform lacking the critical intracellular signaling tail observed in the full length (FL−) RAGE. Proteomic analysis suggests DN-RAGE likely plays a crucial role in cell polarity, metastases, and in cell-cell or cell-matrix complexes through focal adhesion or adherens junction formation. DN-RAGE may also regulate the expression of FL-RAGE and may provide a “switch” that could transition from a pro-inflammatory to a migratory cell as vimentin expression increased along with a reduction in cell polarity proteins. STRING interactome analysis identified seven protein–protein interaction networks involved in the regulation of gene expression, cell organization, cytoskeletal changes, sub-membrane plaque formation, as well as cytokinesis, cell shape, and motility. Suggesting expression of DN-RAGE may contribute to metastases and the development of advanced cancer.

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The Effect of Diabetes Mellitus on Prognosis of Patients with Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis

Cited by 25 publications

References 47 publications

The role of multimorbidity in short-term mortality of lung cancer patients in Spain: a population-based cohort study

The role of multimorbidity in short-term mortality of lung cancer patients in Spain: a population-based cohort study

Rupture of pulmonary hydatid cyst in pediatrics: A cross-sectional study

Analysis of RAGE Proteome and Interactome in Lung Adenocarcinoma Using PANTHER and STRING Databases

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