Prognostic significance of CD147 in patients with glioblastoma

Abstract

CD147, also known as extracellular matrix metalloproteinase inducer, is a widely distributed cell surface glycoprotein that belongs to the immunoglobulin superfamily. CD147 has been proved to be enriched on the surface of many tumor cells, promoting tumor growth, invasion and metastasis by its stimulation effect on adjacent fibroblasts to produce matrix metalloproteinases. In this study, we aimed to explore the expression pattern of CD147 in glioblastoma (GBM) and investigate whether it could be used to assess subsequent prognosis of patients. For that, we recruited a total of 206 patients with pathologically confirmed GBM and 36 normal control brain tissue specimens. The expression of CD147 in GBM and normal tissues was investigated by immunohistochemistry assay. Genetic factors including MGMT and IDH1 mutation were also investigated to justify the prognostic significance of CD147. Results showed that CD147 expression was increased in GBM compared with that in normal tissues. Kaplan-Meier analysis showed that increased CD147 expression was associated with poor overall survival of patients with GBM. Moreover, Cox's proportional hazards model revealed that CD147 expression was an independent and significant prognostic marker of overall survival in GBM patients. These results proved that CD147 expression was relatively abundant in GBM and can be potentially used to predict prognosis and treatment response in GBM patients.

The Biological Function and Clinical Utilization of CD147 in Human Diseases: A Review of the Current Scientific Literature

“…CD147 is central in the promotion of tumor invasion, growth/progression and metastasis because it up-regulates MMPs secreted from adjacent fibroblasts [98] through mostly unknown mechanisms. MMPs stimulated by CD147 degrade the extracellular matrix [99] and underlie tumorigenesis, while many of the proinflammatory cytokines and other mediators production stimulated by CD147 have also been directly linked to cancer [52,76].…”

“…Indeed, CD147 has been suggested as a prognostic marker in endometrial cancer [65], gastric cancer [96], glioblastoma [98], HCC [78], lupus nephritis [130], UCB [94] and other diseases. Patients with high CD147 expression have a poor prognosis [104], while multivariate analysis revealed that the expression of CD147 is an independent prognostic factor for patients with NSCLC [81,176].…”

“…CD147 may also represent a potential predictor of the degree of malignancy in OSCC [86] and tumor metastasis in HSCC [116]. Boye et al [177] suggest that CD147 could be used in the selection of stage III patients for adjuvant therapy for colorectal cancer, and Yang et al [98] showed that CD147 expression is associated with poor overall survival in patients with glioblastoma and suggest that CD147 may be used to detect treatment response in glioblastoma patients. Together, recent findings suggest that low CD147 expression may be a predictor of favorable prognosis and a prognostic indicator of malignant tumors [76].…”

Elevated CD147 expression is associated with shorter overall survival in non-small cell lung cancer

“…CD147 can also degrade the basement membrane and consequently promote tumor invasion. It is reported that CD147 is highly expressed in various malignant tumors and is associated with survival outcomes [10–16]. Previous studies also investigated the relationship between CD147 and NSCLC prognosis, however, those results were controversial [17–26].…”

CD147 as a Novel Prognostic Biomarker for Hepatocellular Carcinoma: A Meta-Analysis

“…Earlier studies demonstrated that the CD147 molecule was highly expressed on the surface of various cancer cells, including cancers of the liver, lung, breast, kidney, colon, prostate, and esophagus [12]. There is emerging evidence indicating that CD147 plays a central role in the progression of many cancers due to increased adhesion, migration, invasion, and matrix metalloproteinases [13–16]. Importantly, increased expression of cancer-associated CD147 predicts aggressive behavior and poor prognosis [12, 17–20].…”