Prognostic significance of Body Mass index in patients with localized renal cell carcinoma

Abstract

Objective: To investigate the relationship between the pretreatment body mass index (BMI) and the clinical outcomes in patients with localized stage I - III renal cell carcinoma (RCC) surgically treated. Materials and Methods: From January 2000 to December 2012, 798 patients with stage I - III RCC were recruited from First Affiliated Hospital and Cancer Center of Sun Yat - Sen University. Patients were divided into two groups of BMI < 25 kg / m2 or BMI ≥ 25 kg / m2 according to the World Health Organization classifications for Asian populations. The differences in the long-term survival of these two BMI groups were analyzed. Results: The 5 - year failure - free survival rates for BMI < 25 kg / m2 and BMI ≥ 25 kg / m2 groups were 81.3% and 93.3%, respectively (P = 0.002), and the 5 - year overall survival rates were 82.5% and 93.8%, respectively (P = 0.003). BMI was a favored prognostic factor of overall survival and failure - free survival in a Cox regression model. Conclusions: Pretreatment body mass index was an independent prognostic factor for Chinese patients surgically treated, localized stage I - III RCC.

Survival Rate of Kidney Cancer in the Asian Countries: A Systematic Review and Meta-Analysis study

“…The included studies got published from 1998 to 2022. Based on geographical locations, fteen studies were conducted in Korea (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34), fourteen in China (35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48), six in Japan (49)(50)(51)(52)(53)(54), one in Singapore (55), four in Thailand (56-59), one in India (60) and one in Sri Lanka (61). Characteristics of the included studies are illustrated in Table 1.…”

Electrocatalysis enabled transformation of earth-abundant water, nitrogen and carbon dioxide for a sustainable future

“…Recently, an enhanced electrocatalytic performance of Mo 2 C was demonstrated by embedding Mo 2 C nanoparticles in nitrogen-doped carbon nanosheet/graphene (Mo 2 C@N-DC/G) aerogel films. 156 The carbon nanomaterial has a high surface area which prevents the aggregation of Mo 2 C nanocrystals, as well as protects the metal catalysts from acid corrosion, enhances the stability in an acidic medium and simultaneously serves as ''electron highways'' for rapid electron transfer. 157 Moreover, the heteroatom N dopant modifies the surface chemistry with different defects and alters the electronic structure of the catalysts, leading to optimized adsorption energy of the key intermediates on the surface.…”