Prognostic Significance of 18F-FDG PET/CT Metabolic Parameters and Tumor Galectin-1 Expression in Patients With Surgically Resected Lung Adenocarcinoma

Zheng, Hong-Na; Cui, Yan; Li, Xuena; Du, Bulin; Li, Yaming

doi:10.1016/j.cllc.2019.04.002

Cited by 7 publications

(6 citation statements)

References 33 publications

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“…Schulkens et al (19) identified that galectin-1 was a significant prognostic factor for OS and progression-free survival (PFS) by performing extensive galectin expression profiling in a cohort of 87 non-small cell lung cancer patients. Zheng et al (20) presented that positive expression of tumor galectin-1 could predict worse OS and PFS in a cohort of 96 surgically resected lung adenocarcinoma patients. In our study, we also found that overexpression of tumor galectin-1 had the trend of worse OS, and significantly worse LRPFS and DMFS in a cohort of 41 lung adenocarcinoma patients after radiation therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Zheng et al. ( 20 ) presented that positive expression of tumor galectin-1 could predict worse OS and PFS in a cohort of 96 surgically resected lung adenocarcinoma patients. In our study, we also found that overexpression of tumor galectin-1 had the trend of worse OS, and significantly worse LRPFS and DMFS in a cohort of 41 lung adenocarcinoma patients after radiation therapy.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic Significance of Galectin-1 but Not Galectin-3 in Patients With Lung Adenocarcinoma After Radiation Therapy

Huang

Chuang

et al. 2022

Front. Oncol.

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IntroductionTo investigate the role of tumor galectin-1 and galectin-3 in patients with lung adenocarcinoma after definitive radiation therapy.MethodsA total of 41 patients with localized lung adenocarcinoma undergoing thoracic radiation therapy without concurrent chemotherapy were enrolled. Their paraffin-embedded lung tissues were sent for immunohistochemical staining for galectin-1 and galectin-3. The clinical treatment outcomes, including overall (OS), locoregional progression-free (LRPFS), and distant metastasis-free (DMFS) survivals, were evaluated. Univariable and multivariable Cox regression analyses were applied.ResultsOverexpression of tumor galectin-1 and galectin-3 were found in 26.8% and 19.5% of patients, respectively. Overexpression of tumor galectin-1 was the most significant prognosticator to predict worse LRPFS in both univariable (p = 0.007) and multivariable analyses (p = 0.022). Besides, patients with overexpression of tumor galectin-1 had a trend of worse OS (p = 0.066) than those with low expression in multivariable analysis, and worse DMFS (p = 0.035) in univariable analysis. The overexpression of tumor galectin-3 had no significant effect on survival outcomes.ConclusionsThe overexpression of tumor galectin-1, but not galectin-3, is associated with poor LRPFS of patients with lung adenocarcinoma after thoracic radiation therapy. Future research on the mechanism of galectin-1 affecting radiation response in lung adenocarcinoma may be worth exploring.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Galectin-1 but Not Galectin-3 in Patients With Lung Adenocarcinoma After Radiation Therapy

Huang

Chuang

et al. 2022

Front. Oncol.

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“…To this purpose, a number of reports have recently evaluated the complementarity and/or associations between imaging and histopathological features in HNSCC [10][11][12][13][14][15], as well as in different malignancies, i.e. breast cancer, lung adenocarcinoma and glioma [16][17][18]. The ultimate goal of this is to determine which parameters or their combinations could be appropriately used in clinical practice for a more precise diagnosis and treatment of these cancers.…”

Section: Introductionmentioning

confidence: 99%

Correlation between histogram-based DCE-MRI parameters and 18F-FDG PET values in oropharyngeal squamous cell carcinoma: Evaluation in primary tumors and metastatic nodes

et al. 2020

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Objectives To investigate the correlation between histogram-based Dynamic Contrast-Enhanced magnetic resonance imaging (DCE-MRI) parameters and positron emission tomography with 18 F-fluorodeoxyglucose (18 F-FDG-PET) values in oropharyngeal squamous cell carcinoma (OPSCC), both in primary tumors (PTs) and in metastatic lymph nodes (LNs). Methods 52 patients with a new pathologically-confirmed OPSCC were included in the present retrospective cohort study. Imaging including DCE-MRI and 18 F-FDG PET/CT scans were acquired in all patients. Both PTs and the largest LN, if present, were volumetrically contoured. Quantitative parameters, including the transfer constants, K trans and K ep , and the volume of extravascular extracellular space, v e , were calculated from DCE-MRI. The percentiles (P), P10, P25, P50, P75, P90, and skewness, kurtosis and entropy were obtained from the histogram-based analysis of each perfusion parameter. Standardized uptake values (SUV), SUV max , SUV peak , SUV mean , metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were calculated applying a SUV threshold of 40%. The correlations between all variables were investigated with the Spearman-rank correlation test. To exclude false positive results under multiple testing, the Benjamini-Hockberg procedure was applied.

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“…Zheng et al reported that Gal-1 expression was correlated with tumor volume and glycolysis-related markers (GLUT-1 and hexokinase II), which may serve as an independent prognostic marker in lung adenocarcinoma [ 89 ]. Park et al showed that Toll-like receptor 4 (TLR4) increases Gal-1-mediated ADAM metallopeptidase domain 10 (ADAM10) and ADAM17, which promotes lactate (2-hydroxypropanoic acid) production [ 79 ].…”

Section: The Roles Of Galectins In Cancer Metabolism Reprogrammingmentioning

confidence: 99%

“…Furthermore, Apicella et al showed that tumor-associated stromal cells, such as cancer-associated fibroblasts, could take up lactate to stimulate production and to increase tumor cell resistance to therapy [ 125 ], indicating that Gal promotes lactate production and may create a more acidic microenvironment for tumor cells. In addition, cancer cell-mediated lactate production triggers hypoxia-inducible factor 1α (HIF-1α) expression under hypoxic conditions [ 126 ] and the expression of glucose transporters but also the regulated expression of Gal-1 [ 89 ], which may form a regulatory loop between tumor cells and tumor-associated cells. Gal-1 is highly expressed in lymphoma, and its concentration was correlated with lactate dehydrogenase (LDH) expression [ 127 ].…”

Section: The Roles Of Galectins In Cancer Metabolism Reprogrammingmentioning

confidence: 99%

Galectins in Cancer and the Microenvironment: Functional Roles, Therapeutic Developments, and Perspectives

Chang

Chan

et al. 2021

Biomedicines

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Changes in cell growth and metabolism are affected by the surrounding environmental factors to adapt to the cell’s most appropriate growth model. However, abnormal cell metabolism is correlated with the occurrence of many diseases and is accompanied by changes in galectin (Gal) performance. Gals were found to be some of the master regulators of cell–cell interactions that reconstruct the microenvironment, and disordered expression of Gals is associated with multiple human metabolic-related diseases including cancer development. Cancer cells can interact with surrounding cells through Gals to create more suitable conditions that promote cancer cell aggressiveness. In this review, we organize the current understanding of Gals in a systematic way to dissect Gals’ effect on human disease, including how Gals’ dysregulated expression affects the tumor microenvironment’s metabolism and elucidating the mechanisms involved in Gal-mediated diseases. This information may shed light on a more precise understanding of how Gals regulate cell biology and facilitate the development of more effective therapeutic strategies for cancer treatment by targeting the Gal family.

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Prognostic Significance of 18F-FDG PET/CT Metabolic Parameters and Tumor Galectin-1 Expression in Patients With Surgically Resected Lung Adenocarcinoma

Cited by 7 publications

References 33 publications

Prognostic Significance of Galectin-1 but Not Galectin-3 in Patients With Lung Adenocarcinoma After Radiation Therapy

Prognostic Significance of Galectin-1 but Not Galectin-3 in Patients With Lung Adenocarcinoma After Radiation Therapy

Correlation between histogram-based DCE-MRI parameters and 18F-FDG PET values in oropharyngeal squamous cell carcinoma: Evaluation in primary tumors and metastatic nodes

Galectins in Cancer and the Microenvironment: Functional Roles, Therapeutic Developments, and Perspectives

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