Correlation between histogram-based DCE-MRI parameters and 18F-FDG PET values in oropharyngeal squamous cell carcinoma: Evaluation in primary tumors and metastatic nodes

Vidiri, Antonello; Gangemi, Emma; Ruberto, Emanuela; Pasqualoni, Rosella; Sciuto, Rosa; Sanguineti, Giuseppe; Farneti, Alessia; Benevolo, Maria; Rollo, Francesca; Sperati, Francesca; Spasiano, Filomena; Pellini, Raul; Marzi, Simona

doi:10.1371/journal.pone.0229611

Cited by 8 publications

(17 citation statements)

References 46 publications

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“…The possible impact of HPV status on DCE-MRI parameters was also investigated. Consistent with earlier literature, any difference in vascularity was reported based on HPV status for primary tumors and lymph nodes [36,42,43].…”

Section: Discussionsupporting

confidence: 87%

Multiparametric MRI Evaluation of Oropharyngeal Squamous Cell Carcinoma. A Mono-Institutional Study

Piludu

Marzi

Gangemi

et al. 2021

JCM

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The aim of this paper is to define the pre-treatment radiological characteristics of oropharyngeal squamous cell carcinoma (OPSCC) using morphological and non-morphological magnetic resonance imaging (MRI), based on HPV status, in a single-institution cohort. In total, 100 patients affected by OPSCC were prospectively enrolled in the present study. All patients underwent 1.5T MR with standard sequences, including diffusion-weighted imaging with and intravoxel incoherent motion (IVIM-DWI) technique and a dynamic contrast-enhanced (DCE) MRI. For all patients, human papillomavirus (HPV) status was available. No statistically significant differences in the volume of primary tumors (PTs) and lymph nodes (LNs) were observed based on HPV status. When comparing the two patient groups, no significant differences were found for the PT radiologic characteristics (presence of well-defined borders, exophytic growth, ulceration, and necrosis) and LN morphology (solid/cystic/necrotic). Tumor subsite, smoking status, and alcohol intake significantly differed based on HPV status, as well as ADC and Dt values of both PTs and LNs. We detected no significant difference in DCE-MRI parameters by HPV status. Based on a multivariate logistic regression model, the combination of clinical factors, such as tumor subsite and alcohol habits, with the perfusion-free diffusion coefficient Dt of LNs, may help to accurately discriminate OPSCC by HPV status.

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Section: Discussionsupporting

confidence: 87%

Multiparametric MRI Evaluation of Oropharyngeal Squamous Cell Carcinoma. A Mono-Institutional Study

Piludu

Marzi

Gangemi

et al. 2021

JCM

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“…For the reference standard, the main concern was the use of different HPV determination methods for different patients or the exclusive use of p16 immunohistochemistry for HPV determination [ 20 , 21 , 22 , 23 , 26 , 31 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. The main concern for patient selection was the lack of information on consecutive or random patient selection and the exclusion of patients with lower-stage OPSCC [ 20 , 25 , 27 , 35 , 36 , 37 , 38 , 39 , 45 , 46 , 47 ]. Regarding the index test, the main concern was the lack of pre-specification of thresholds or independent validation [ 21 , 25 , 26 , 27 , 31 , 39 , 40 , 41 , 46 , 47 , 48 ].…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-one studies had a retrospective cohort study design [2,[19][20][21][22]25,26,28,29,31,32,35,[37][38][39]42,44,45,[47][48][49], and seven studies had a prospective cohort study design [23,27,40,41,43,46,50]. Of the twentyeight included papers, five papers focused on structural MRI sequences that were used in routine clinical examinations [19][20][21][22][23], nineteen focused on DWI sequences [2,25,[27][28][29]31,32,35,36,38,39,41,42,[44][45][46][47]...…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Eleven studies used 1.5T MRI scanners [19,25,27,28,38,43,[45][46][47]49,50], nine studies used 3.0T MRI scanners [20,22,26,29,32,37,40,41,44], and eight studies used a combination of 1.5T and 3.0T MRI scanners [2,21,23,31,35,39,42,48]. Of the twenty-eight studies, nineteen investigated OPSCC exclusively [19][20][21][22][23]27,29,31,32,37,38,40,42,[44][45][46][47][48][49], three studies investigated oral cavity (OC)SCC as well as OPSCC [2,26,28], and ...…”

Section: Study Characteristicsmentioning

confidence: 99%

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MRI for Differentiation between HPV-Positive and HPV-Negative Oropharyngeal Squamous Cell Carcinoma: A Systematic Review

Chen,

Lauwers,

Verduijn

et al. 2024

Cancers

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Human papillomavirus (HPV) is an important risk factor for oropharyngeal squamous cell carcinoma (OPSCC). HPV-positive (HPV+) cases are associated with a different pathophysiology, microstructure, and prognosis compared to HPV-negative (HPV−) cases. This review aimed to investigate the potential of magnetic resonance imaging (MRI) to discriminate between HPV+ and HPV− tumours and predict HPV status in OPSCC patients. A systematic literature search was performed on 15 December 2022 on EMBASE, MEDLINE ALL, Web of Science, and Cochrane according to PRISMA guidelines. Twenty-eight studies (n = 2634 patients) were included. Five, nineteen, and seven studies investigated structural MRI (e.g., T1, T2-weighted), diffusion-weighted MRI, and other sequences, respectively. Three out of four studies found that HPV+ tumours were significantly smaller in size, and their lymph node metastases were more cystic in structure than HPV− ones. Eleven out of thirteen studies found that the mean apparent diffusion coefficient was significantly higher in HPV− than HPV+ primary tumours. Other sequences need further investigation. Fourteen studies used MRI to predict HPV status using clinical, radiological, and radiomics features. The reported areas under the curve (AUC) values ranged between 0.697 and 0.944. MRI can potentially be used to find differences between HPV+ and HPV− OPSCC patients and predict HPV status with reasonable accuracy. Larger studies with external model validation using independent datasets are needed before clinical implementation.

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“…[54][55][56] Several studies evaluated the relationships between DCE-MRI and 18F-FDG-PET/CT parameters in primary HN tumors and metastatic LNs. [57][58][59][60] Vidiri et al 61 studied 52 patients with a new pathologically confirmed OP-SCC using DCE-MRI and 18F-FDG-PET/CT imaging methods. The group researched the PTs and the largest LN using quantitative DCE-MRI parameters including the transfer constants, K trans and k ep , and the volume of EES, V e (Fig.…”

Section: Correlation Between Dce-mri Parameters and 18f-fdg In Oropha...mentioning

confidence: 99%

MRI Dynamic Contrast Imaging of Oral Cavity and Oropharyngeal Tumors

Sideras

Singh

2021

Topics in Magnetic Resonance Imaging

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In the past decade, dynamic contrast-enhanced magnetic resonance imaging has had an increasing role in assessing the microvascular characteristics of various tumors, including head and neck cancer. Dynamic contrast-enhanced magnetic resonance imaging allows noninvasive assessment of permeability and blood flow, both important parametric features of tumor hypoxia, which is in turn a marker for treatment resistance for head and neck cancer. In this article we will provide a comprehensive review technique in evaluating tumor proliferation and application of its parameters in differentiating between various tumor types of the oral cavity and how its parameters can correlate between epidermal growth factor receptor and human papillomavirus which can have an implication in patient's overall survival rates. We will also review how the parameters of this method can predict local tumor control after treatment and compare its efficacy with other imaging modalities. Lastly, we will review how its parameters can be used prospectively to identify early complications from treatment.

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Correlation between histogram-based DCE-MRI parameters and 18F-FDG PET values in oropharyngeal squamous cell carcinoma: Evaluation in primary tumors and metastatic nodes

Cited by 8 publications

References 46 publications

Multiparametric MRI Evaluation of Oropharyngeal Squamous Cell Carcinoma. A Mono-Institutional Study

Multiparametric MRI Evaluation of Oropharyngeal Squamous Cell Carcinoma. A Mono-Institutional Study

MRI for Differentiation between HPV-Positive and HPV-Negative Oropharyngeal Squamous Cell Carcinoma: A Systematic Review

MRI Dynamic Contrast Imaging of Oral Cavity and Oropharyngeal Tumors

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