Prognostic significance and functional implication of immune activating receptor NKG2D in gastric cancer

Lin, Feng; Dai, Congqi; Ge, Xiaoxiao; Tang, Wenbo; Lin, Ying; Wang, Yan; Li, Jin

doi:10.1016/j.bbrc.2017.04.104

Cited by 10 publications

(7 citation statements)

References 32 publications

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“…In a recent study, Kim et al revealed that decreasing NOVA1 expression in tumor tissue was related to tumor progression and poor prognosis via immune dysfunction of T cells and macrophages [ 54 ]. And Th12 [ 55 ], Th17 [ 37 , 56 ], Th1 [ 57 ], CX3C chemokines [ 58 ], diversity index of mucosal resident T lymphocyte [ 59 ], myeloid derived suppressing cells [ 60 ], immune activating receptor NKG2D [ 61 ], CCR7 [ 62 ], and IL-10 [ 63 ] are also involved in the progression and prognosis of GCs.…”

Section: Other Cells and Molecule Related T Cell Immunity In Gcsmentioning

confidence: 99%

The Progress of T Cell Immunity Related to Prognosis in Gastric Cancer

Wei

Shen

Shrestha

et al. 2018

BioMed Research International

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Gastric cancer is the fifth most common malignancy all over the world, and the factors that can affect progress and prognosis of the gastric cancer patients are various, such as TNM stages, invasive depth, and lymph node metastasis ratio. T cell immunity is important component of human immunity system and immunity responding to tumor and dysfunction or imbalance of T cell immunity will lead to serious outcomes for body. T cell immunity includes many different types of cells, CD4+ T cell, CD8+ T cell, memory cell, and so on, and each of them has special function on antitumor response or tumor immune escape which is revealed in lung cancer, colorectal cancer, breast cancer, ovarian cancer, and so on. But its correlation with gastric cancer is not clear. Our review was preformed to explore the relationship between the progress and prognosis of gastric cancer (GC) and T cell immunity. According to recent researches, T cell immunity may have an important role in the progress and prognosis of GCs, but its function is affected by location, category, related molecule, and interaction between the cells, and some effects still are controversial. More researches are needed to clarify this correlation.

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Section: Other Cells and Molecule Related T Cell Immunity In Gcsmentioning

confidence: 99%

The Progress of T Cell Immunity Related to Prognosis in Gastric Cancer

Wei

Shen

Shrestha

et al. 2018

BioMed Research International

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“…The NKG2D‐NKG2DL interaction plays a key immunomodulatory role and can be used as a prognostic indicator in patients with GC 30 . NKG2DL is usually expressed only when cells are infected or cancerous.…”

Section: Discussionmentioning

confidence: 99%

Linc‐ROR inhibits NK cell‐killing activity by promoting RXRA ubiquitination and reducing MICB expression in gastric cancer patients

Niu,

Li,

Jiang

et al. 2024

J of Cellular Biochemistry

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Linc‐ROR plays an important role in gastric cancer (GC) development and progression. This study sought to determine how the aberrant expression of Linc‐ROR impacts GC progression and immune evasion, and to identify new targets for GC therapy. GC cells overexpressing Linc‐ROR and GSAGS cells were cocultured with NK‐92 cells, respectively, and Linc‐ROR expression was determined using reverse transcription polymerase chain reaction. Linc‐ROR overexpression experiments were used to measure the expression of MICB, a tumor protein that is recognized by natural killer (NK) cells. Bioinformatics analysis identified retinoid X receptor α (RXRA) and YY1 as MICB‐specific transcription factors. Cotransfection and ubiquitinated drug experiments found that Linc‐ROR promoted the ubiquitination and degradation of RXRA. Linc‐ROR was upregulated in GC tissue and high expression was associated with tumor escape from NK‐92 cell‐mediated immunity. Linc‐ROR overexpression inhibited the expression of MICB on the cell surface by degrading RXRA. These findings indicate that Linc‐ROR promotes the binding of RXRA and E3 ligase UBE4B, reducing RXRA and MICB expression, and limiting NK cell‐killing activity. Linc‐ROR is a critical long noncoding RNA with a tumor‐promoting function in GC and thus may serve as a potential therapeutic target.

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“…High NKG2D mRNA level is significantly associated with death risk reduction in patients with gastric cancer. Treatment with chimeric NKG2D-expressing T cells is a potential immunotherapy for gastric cancers with peritoneal metastasis [94,95]. Paradoxically, in certain advanced cancers, tumor progression is connected with high levels of NKG2D despite overexpression of NKG2DLs on the surface of cancer cells [96].…”

Section: Cancers and Cancer Immunotherapymentioning

confidence: 99%

NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications

Siemaszko

Marzec-Przyszlak

Bogunia‐Kubik

2021

Cells

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Natural Killer (NK) cells are natural cytotoxic, effector cells of the innate immune system. They can recognize transformed or infected cells. NK cells are armed with a set of activating and inhibitory receptors which are able to bind to their ligands on target cells. The right balance between expression and activation of those receptors is fundamental for the proper functionality of NK cells. One of the best known activating receptors is NKG2D, a member of the CD94/NKG2 family. Due to a specific NKG2D binding with its eight different ligands, which are overexpressed in transformed, infected and stressed cells, NK cells are able to recognize and attack their targets. The NKG2D receptor has an enormous significance in various, autoimmune diseases, viral and bacterial infections as well as for transplantation outcomes and complications. This review focuses on the NKG2D receptor, the mechanism of its action, clinical relevance of its gene polymorphisms and a potential application in various clinical settings.

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Prognostic significance and functional implication of immune activating receptor NKG2D in gastric cancer

Cited by 10 publications

References 32 publications

The Progress of T Cell Immunity Related to Prognosis in Gastric Cancer

The Progress of T Cell Immunity Related to Prognosis in Gastric Cancer

Linc‐ROR inhibits NK cell‐killing activity by promoting RXRA ubiquitination and reducing MICB expression in gastric cancer patients

NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications

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