Prognostic role of the pre-treatment platelet-lymphocyte ratio in pancreatic cancer: a meta-analysis

Xu, Zhengshui; Zhang, Fa-Peng; Zhang, Yin; Ouyang, Yaofu; Yu, Xiaowen; Wang, Wenlong; Wang, Xu; Luo, Zhiqiang

doi:10.18632/oncotarget.20871

Cited by 16 publications

(14 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many authors have analyzed the role of inflammation and inflammatory factors in predicting survival in various tumors, including pancreatic cancer. Pretreatment neutrophil to lymphocyte ratio [11,18], lymphocyte to monocyte ratio [19], and PLR [20][21][22] were identified as possible factors associated with OS in pancreatic cancer patients. However, the mechanisms responsible for PLR being related to outcomes in cancer patients are still not entirely understood, while factors related to inflammation are known for their role in carcinogenesis.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Preoperative Platelet to Lymphocyte Ratio as a Prognostic Factor for Resectable Pancreatic Cancer: A Systematic Review and Meta-Analysis

Riauka

Ignatavičius

Barauskas³

2020

Dig Surg

View full text Add to dashboard Cite

Introduction: Various inflammatory markers have been investigated for a prognostic role in patients with resectable pancreatic cancer. However, the value of preoperative platelet to lymphocyte ratio (PLR) remains controversial. We performed a systematic review and meta-analysis of PLR as a preoperative prognostic factor for resectable pancreatic cancer. Material and Methods: Systematic literature search was conducted for studies assessing PLR influence as a preoperative prognostic factor in resectable pancreatic cancer patients. Random-effects model was applied for pooling hazard ratios and 95% confidence intervals related to overall survival (OS) and disease-free survival (DFS). Results: Fourteen articles with 2,743 patients were included in the study. According to the analysis, high PLR had no correlation with decreased OS. Due to high heterogeneity among studies, subgroup analysis was performed. Better OS was associated with low PLR in Asian patients, patients with mixed type of operation performed, and patients with preoperative PLR ≤150. Low PLR was associated with significantly better DFS. Conclusions: PLR is a predictive factor of better DFS in patients with resectable pancreatic cancer. However, available evidence does not support PLR as a reliable prognostic factor for OS.

show abstract

Section: Discussion/conclusionmentioning

confidence: 99%

Preoperative Platelet to Lymphocyte Ratio as a Prognostic Factor for Resectable Pancreatic Cancer: A Systematic Review and Meta-Analysis

Riauka

Ignatavičius

Barauskas³

2020

Dig Surg

View full text Add to dashboard Cite

show abstract

“…However, the precise role of these immunologic parameters in PDAC remains controversial. In recent meta‐analyses, these parameters have been reported to be useful in predicting the prognosis of pancreatic cancer, although there are some contradictions . However, as far as we know, there are no studies focusing on the total lymphocyte count in left‐sided pancreatic cancer.…”

Section: Introductionmentioning

confidence: 99%

Association of preoperative total lymphocyte count with prognosis in resected left‐sided pancreatic cancer

Rho

Hwang

Chong

et al. 2019

ANZ Journal of Surgery

View full text Add to dashboard Cite

Background: Immunologic factors such as neutrophil-lymphocyte ratio and platelet-lymphocyte ratio play an important role in predicting the oncologic outcome of patients in pancreatic ductal adenocarcinoma (PDAC). It is hypothesized that host immunity represented by total lymphocyte count at diagnostic stage would influence oncologic outcome in left-sided PDAC. Methods: Between January 1992 and August 2017, total of 112 patients who underwent distal pancreatectomy for left-sided PDAC were included and analysed. Results: At the time of the diagnosis, total lymphocyte count at diagnosis of left-sided PDAC was 1.8 AE 0.7 10 3 /μL (mean value AE standard deviation). Among different cut-off values, 1.7 showed most powerful significant differences in long-term oncologic outcomes. The patients with preoperative lymphocyte count (≤1.7) was associated with early recurrence (median 8.4 months versus 18.1 months, P = 0.011) and shorter survival (median 18.6 months versus 35.9 months, P = 0.028). Patients with preoperative total lymphocyte count over 1.7 showed higher white blood cell count (P < 0.001), platelet count (P = 0.039), neutrophil count (P = 0.004) and monocyte count (P = 0.001). However, more interestingly, neutrophil-lymphocyte ratio (P < 0.001) and platelet-lymphocyte ratio (P < 0.001) were found to be significantly higher in those with total lymphocyte count less than 1.7. Lymphocyte to monocyte ratio was inversely related to preoperative total lymphocyte count (P < 0.001). Only age was identified to be significantly different (P = 0.007). However, other clinicopathological parameters generally known to be related to tumour aggressiveness, were not different between two groups. Conclusion: In conclusion, preoperative total lymphocyte at diagnostic stage is simple, and good prognostic factor in left-sided pancreatic cancer.

show abstract

“…They have been shown to be associated with various inflammatory and cardiovascular diseases, and cancer. Furthermore, these parameters are now being evaluated as prognostic indicators for pre-treatment in some inflammatory diseases and cancer 17-19. However, the relationship between N/L, P/L, and PMO has not yet been fully elucidated.…”

mentioning

confidence: 99%

Platelet/lymphocyte ratio is an independent predictor for osteoporosis

Eroğlu

Karataş²

2019

SMJ

View full text Add to dashboard Cite

Objectives: To investigate the intercourse between the platelet/lymphocyte (P/L) and neutrophil/lymphocyte ratio (N/L), and vitamin D (Vit-D) levels in low bone mineral density (BMD) of women. Methods: Two hundred fifty-two postmenopausal female outpatients who were admitted to the obstetrics and gynecology and physical therapy clinics between July 2016 and December 2017 were retrospectively analyzed. The patients were grouped in relation to their T-score (normal [n=92], osteopenia [n=112], and PMO [n=48]). The serum levels of P/L, N/L, Vit-D, BMD and complete blood count of the patients were retrospectively examined. Results: The median P/L was significantly higher and Vit-D levels were significantly lower in the PMO group (130.75 [52.89-385] versus 123.05 [54-232.5], p =0.02 and 15.4 [4-34] versus 20.1 [4-47], p =0.003). While BMD and P/L were negatively correlated, a positive correlation between BMD and Vit-D was found. Vitamin D levels were negatively correlated with P/L ( p <0.001) and N/L ( p =0.04). Older age (≥65 years), Vit-D deficiency and P/L values >125.06 were found as independent prognostic factors for PMO in regression analysis. Conclusion: Higher P/L seems to be a quite simple marker to help predict postmenopausal PMO. As seen in our study, having low levels of Vit-D is crucial for PMO.

show abstract

Prognostic role of the pre-treatment platelet-lymphocyte ratio in pancreatic cancer: a meta-analysis

Cited by 16 publications

References 37 publications

Preoperative Platelet to Lymphocyte Ratio as a Prognostic Factor for Resectable Pancreatic Cancer: A Systematic Review and Meta-Analysis

Preoperative Platelet to Lymphocyte Ratio as a Prognostic Factor for Resectable Pancreatic Cancer: A Systematic Review and Meta-Analysis

Association of preoperative total lymphocyte count with prognosis in resected left‐sided pancreatic cancer

Platelet/lymphocyte ratio is an independent predictor for osteoporosis

Contact Info

Product

Resources

About