Prognostic Role of MicroRNA-181a/b in Hematological Malignancies: A Meta-Analysis

Abstract

BackgroundEmerging evidence has shown that miRNAs participate in human carcinogenesis as tumor suppressors or oncogenes, and have prognostic value for patients with cancers. In recent years, the miR-181 family was found dysregulated in a variety of human cancers and significantly associated with clinical outcome of cancerous patients. MiR-181a and miR-181b (miR-181a/b) were the most investigated members in the family. However, the results of miR-181a/b from different studies were inconsistent. Therefore, we performed a meta-analysis to summarize all the results from available studies, aiming to delineate the prognostic role of miR-181a/b in human cancers.MethodsThe identified articles were retrieved from the two main on-line databases, PubMed and EMBASE. We extracted and estimated the hazard ratios (HRs) for overall survival (OS), which compared the high and low expression levels of miR-181a/b in patients of the available studies. Each individual HR was used to calculate the pooled HR.ResultsEleven studies of 1252 patients were selected into the final meta-analysis after a strict filtering and qualifying process. Fixed model or random model method was chosen depending on the heterogeneity between the studies. The subgroup analysis showed that high expressed miR-181a/b could prolong OS in patients with hematological malignancies rather than low expression level (HR = 0.717, P<0.0001). But the expression of miR-181a/b was not significantly relative to OS in patients with various cancers (HR = 0.861, p = 0.356).ConclusionOur study indicates that the expression level of miR-181a/b is significantly associated with OS in hematological malignancies and can be an important clinical prognostic factor for those patients.

High IDH1 expression is associated with a poor prognosis in cytogenetically normal acute myeloid leukemia

“…In this study, microRNA profiling study was carried out, which revealed that the down‐regulation of miR‐181a, miR‐181d and miR‐181b of the miR‐181 family, proposed as tumor suppressors, was associated with the high expression of IDH1 . However, down‐regulation of miR‐181 family was correlated with hematologic development and poor outcome even though no report showed that expression level of IDH1 was regulated by miR‐181 family . Zhu et al .…”

Up-regulated MicroRNA-181a induces carcinogenesis in Hepatitis B virus-related hepatocellular carcinoma by targeting E2F5

“…Their target genes include numerous regulators of biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, development, and immunity [7,8]. Therefore, miRNAs are implicated in multiple biological processes and aberrant miRNA expression contributes to tumorigenesis and cancer progression [9].…”

“…In recent years, the miR-181 family was found dysregulated in a variety of human cancers and significantly associated with clinical outcome of cancerous patients [8]. It has been reported that miR-181a significantly overexpressed in a wide variety of cancers, such as gastric cancer [11] and oral squamous cell carcinoma [12].…”

Evaluation of miR-27a, miR-181a, and miR-570 Genetic Variants with Gallbladder Cancer Susceptibility and Treatment Outcome in a North Indian Population

“…miRNAs recognize target mRNAs via base pair interactions, which ultimately act as endogenous repressors of target genes, including tumor suppressor genes, e.g., p53, BRCA1-2, and PTEN [35]. Many recent studies are evident of the fact that genetic variants in miRNA affect the progression as well as the prognosis of various malignancies [30,[36][37][38][39]. The present study aimed to determine the role of common genetic variants of miRNA, i.e., miR-27a (rs895819) (A[G), miR-570 (rs4143815) (G[C), and miR-181a (rs12537) (C[T), in susceptibility as well as prognosis of GBC patients in a northern Indian population.…”