Prognostic role of copeptin after stroke: A systematic review and meta-analysis of observational studies

Choi, Kyu Sun; Kim, Hyun Jung; Chun, Hyoung Joon; Kim, Jae Min; Yi, Hyeong Joong; Cheong, Jin Hwan; Kim, Choong Hyun; Oh, Sea Cheon; Ko, Yong; Kim, Young Soo; Bak, Koang Hum; Ryu, Je Il; Kim, Wonhee; Lim, Taeho; Ahn, Hyeong Sik; Ahn, Il Min; Lee, Seon Heui

doi:10.1038/srep11665

Cited by 33 publications

(24 citation statements)

References 38 publications

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“…Also, Kyu-Sun et al [17] postulated that early measurement of plasma copeptin could provide better prognostic information for patients with acute stroke and help in decision making for therapeutic interventions.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Hypothalamic Copeptin in Acute Ischemic Stroke

2016

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Background: Some studies showed that copeptin, a hypothalamic hormone derived from the precursor of vasopressin, may be useful in the prediction of outcome of ischemic cerebral stroke. The aim of this work was to search if there is any correlation between serum copeptin, in the first day of ischemic stroke, and its clinical severity, radiological findings and also its predictive value of functional outcome in these patients.

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Section: Discussionmentioning

confidence: 99%

Prognostic Value of Hypothalamic Copeptin in Acute Ischemic Stroke

2016

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“…Our results suggest that copeptin blood levels taken on a 7-day follow-up have a slightly stronger association with outcome compared to admission results for mortality and adverse clinical outcome prediction. In contrast, a meta-analysis of Choi et al in a different setting showed that early measurement of plasma copeptin in the patients with acute stroke provides better prognostic information about the functional outcome and mortality [46]. Because differences in our study sample were small, further research is needed to define the optimal usage of this marker in the GP setting.…”

Section: Discussionmentioning

confidence: 55%

“…Still, the marker was useful for risk stratification independently of renal function [45]. Also, Choi et al found a standardised mean difference by study region with significant differences in copeptin blood levels, but a positive consistent association of copeptin with poor prognosis [46].…”

Section: Discussionmentioning

confidence: 99%

Copeptin predicts 10-year all-cause mortality in community patients: a 10-year prospective cohort study

Odermatt

Bolliger

Hersberger

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background: Copeptin, the C-terminal part of the arginine vasopressin (AVP) precursor peptide, is secreted in response to stress and correlates with adverse clinical outcomes in the acute-care hospital setting. There are no comprehensive data regarding its prognostic value in the community. We evaluated associations of copeptin levels with 10-year mortality in patients visiting their general practitioner (GP) for a respiratory infection included in a previous trial. Methods: This is a post hoc analysis including data from 359 patients included in the PARTI trial. Copeptin was measured in batch-analysis on admission and after 7 days. We calculated Cox regression models and area under the receiver operating characteristic curve (AUC) to assess an association of copeptin with mortality and adverse outcome. Follow-up data were collected by GP, patient and relative tracing through phone interviews 10 years after trial inclusion. Results: After a median follow-up of 10.0 years, mortality was 9.8%. Median admission copeptin levels (pmol/L) were significantly elevated in non-survivors compared to survivors (13.8, IQR 5.9-27.8; vs. 6.3 IQR 4.1-11.5; p < 0.001). Admission copeptin levels were associated with 10-year all-cause mortality [age-adjusted hazard ratio 1.7 (95% CI, 1.2-2.5); p < 0.001, AUC 0.68]. Results were similar for discharge copeptin levels. Copeptin also predicted adverse outcomes defined as death, pulmonary embolism and major adverse cardiac and cerebrovascular events. Conclusions: In a sample of community-dwelling patients visiting their GP for a respiratory infection, copeptin levels were associated with 10-year all-cause mortality. In conjunction with traditional risk factors, this marker may help to better direct preventive measures in this population.

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“…17 The results from studies on adults [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] and neonates [18][19][20][21][22][23] suggest that copeptin is involved in several pathological conditions and may be used as a marker/predictor of various stress disorders both in adults (eg, central nervous system diseases, diabetes mellitus, metabolic syndrome, sepsis, stroke, infections, and kidney diseases) [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] and in infants/neonates (eg, asphyxia, chorioamnionitis, sepsis, and birth acidosis). [18][19][20][21][22][23] These results suggest a role for copeptin as a diagnostic and prognostic tool in adults with stroke 5,9,...…”

mentioning

confidence: 99%

“…[2][3][4] Copeptin levels also increase in cardiovascular diseases (such as ischemic stroke, acute myocardial infarction, heart failure, and intracerebral hemorrhage) and traumatic brain injury. [4][5][6][7][8] In patients with ischemic stroke, copeptin levels predict functional outcome and mortality at 12 months. 9,10 Furthermore, copeptin levels predict recurrent cerebrovascular events after a transient ischemic attack.…”

mentioning

confidence: 99%