Prognostic Role of Blood KL-6 in Rheumatoid Arthritis-Associated Interstitial Lung Disease

Kim, H.; Choi, Kyung‐Sik; Jacob, Joseph; Song, Jin Woo

doi:10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a1436

Cited by 6 publications

(8 citation statements)

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“…with RA In Korea, several studies were performed to identify the prognosis and outcomes of ILD in patients with RA. ILD itself increased mortality of RA patients [42], and age over 65 at the time of ILD diagnosis, Usual interstitial pneumonia pattern [43], and higher Kerbs von den Lungen-6 (KL-6) level [44] were revealed as poor prognostic factors for survival of RA-ILD patients. However, it is scarce that the prevalence of ILD is identified among representative patients with RA in Korea.…”

Section: ) Prevalence Of Interstitial Lung Disease In Patientsmentioning

confidence: 99%

Epidemiology of Rheumatoid Arthritis in Korea

Kim

Sung

2021

J Rheum Dis

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Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterised by symmetrical involvement of the joints, associated extra-articular manifestations and functional disability. In Korea, several epidemiologic studies reporting prevalence and incidence rates of RA have been conducted using large databases such as claims databases, national surveys, prospective cohort databases or electronic health records; according to these data sources, the estimated prevalence ranged from 0.27% to 1.85%. The prevalence of extra-articular manifestations such as interstitial lung disease (ILD) and Sjögren's syndrome (SS) were also reported, but an issue of external validity of the study results persisted. In this review, we detail the epidemiology of Korean RA patients, focusing on the prevalence of RA and the frequency of systemic extra-articular manifestations including ILD and SS reported in previous studies. In addition, we discuss the current methodological issues which are inherent in Korean epidemiologic studies for patients with RA with understanding of the characteristics of each database.

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Section: ) Prevalence Of Interstitial Lung Disease In Patientsmentioning

confidence: 99%

Epidemiology of Rheumatoid Arthritis in Korea

Kim

Sung

2021

J Rheum Dis

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“…It is expected that future data will be able to predict disease progression of RA-ILD based on the initial biomarker levels. In previous studies, it was found that the frequency of UIP among RA-ILD increased according to KL-6 level, and this was related to mortality [16]. Our study has several limitations.…”

Section: Discussionmentioning

confidence: 70%

“…A recent study found that serum KL-6 is related to the severity of connective tissue disease-associated interstitial lung disease (CTD-ILD) [15]. Other recent studies showed that when KL-6 was elevated above a certain level, the frequency of the usual interstitial pneumonia (UIP) pattern among RA-ILD was high [16], and it was also related to mortality [16,17]. In addition, when compared with the RA-non-ILD group, the KL-6 level was elevated in the RA-ILD group, and positive correlation with the fibrosis score of chest CT was also proven [18].…”

Section: Introductionmentioning

confidence: 99%

Association of Serum Biomarkers With Pulmonary Involvement of Rheumatoid Arthritis Interstitial Lung Disease: From KORAIL Cohort Baseline Data

Moon

Lee²,

Yoon

et al. 2021

J Rheum Dis

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Objective. The increase in mortality in rheumatoid arthritis (RA) patients with interstitial lung disease (ILD) is well known. However, there are few studies on serum markers that can evaluate acute exacerbation or prognosis in RA-ILD patients. The purpose of this study was to identify the association between biomarkers and lung lesions in patients with RA-ILD. Methods. We analyzed 153 patients with serum samples in a prospective, multicenter cohort of Korean RA-ILD patients. The serum levels of biomarkers, matrix metalloproteinase (MMP-7), surfactant protein-D (SP-D), and Krebs von den Lungen-6 (KL-6) were measured and correlated with forced vital capacity (FVC), diffusing capacity for carbon monoxide (DLCO) and the results of computed tomography (CT). CT results were interpreted semi-quantitatively according to the extent of lung lesions (

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“…19,20 KL-6 is being intensively investigated as a circulating biomarker in the context of ILD, 21,22 ILD associated with connective tissue diseases (CTD-ILD), 16,23,24 ILD associated with systemic sclerosis 19,25 and ILD associated with RA. 20,[26][27][28] In this study, we assessed the levels of KL-6 in 89 RA patients; 25 patients without ILD and 64 patients with ILD and evaluated the performance of KL-6 in diagnosis of ILD. Results revealed higher levels of serum KL-6 in RA patients with ILD compared to those without ILD.…”

Section: Discussionmentioning

confidence: 99%

Krebs von den Lungen‐6, a promising marker in evaluating the severity of interstitial lung disease in Egyptian rheumatoid arthritis patients

Hammoda¹,

Salah-ElDin²,

El-Gharbawy³

2021

EJI

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Krebs von den Lungen-6 (KL-6) is one of the mucins associated with interstitial lung disease. We aimed to assess the value of KL-6 as a marker for detecting the presence of interstitial lung disease in Egyptian rheumatoid arthritis patients and to evaluate its ability to assess severity in different grades of interstitial lung disease. The study included 89 rheumatoid arthritis patients; 64 patients with interstitial lung disease and 25 patients without interstitial lung disease. Serum levels of KL-6 were assessed using enzyme linked immunosorbent assay. Levels of KL-6 were higher in patients with interstitial lung disease compared to patients without interstitial lung disease (P< 0.001). KL-6 levels were significantly higher in grade 4 patients than those in grades 1 and 2. Also, KL-6 levels were significantly higher in grade 3 patients than those in grades 1 and 2. Kl-6 levels were also higher in grade 2 patients compared to grade 1 patients. Finally, no difference was observed between grade 4 patients and grade 3 patients. KL-6 levels were significantly higher in usual interstitial pneumonia pattern compared other patterns (P=0.015). In conclusion, KL-6 is a potential circulating biomarker that may have a substantial role in detecting the presence and evaluating the severity of interstitial lung disease among rheumatoid arthritis patients.

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Prognostic Role of Blood KL-6 in Rheumatoid Arthritis-Associated Interstitial Lung Disease

Cited by 6 publications

References 0 publications

Epidemiology of Rheumatoid Arthritis in Korea

Epidemiology of Rheumatoid Arthritis in Korea

Association of Serum Biomarkers With Pulmonary Involvement of Rheumatoid Arthritis Interstitial Lung Disease: From KORAIL Cohort Baseline Data

Krebs von den Lungen‐6, a promising marker in evaluating the severity of interstitial lung disease in Egyptian rheumatoid arthritis patients

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