Association of Serum Biomarkers With Pulmonary Involvement of Rheumatoid Arthritis Interstitial Lung Disease: From KORAIL Cohort Baseline Data

Moon, Jee Youn; Lee, Jeong Seok; Yoon, Young Im; Chang, Sung Hae; Lee, Yeon Ah; Ha, You Jung; Kang, Eun Ha; Park, Yong Bum; Lee, Hwajeong; Choe, Jung Yoon; Lee, Eun Young

doi:10.4078/jrd.2021.28.4.234

Cited by 10 publications

(3 citation statements)

References 31 publications

(52 reference statements)

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“…Additionally, MMP-7 levels correlated with the semi-quantitative grade of CT. Thus, the authors suggested that MMP-7 can be used to measure the functional and anatomical status of lungs in patients with RA-ILD [147].…”

Section: Emtmentioning

confidence: 99%

Etiology and Pathogenesis of Rheumatoid Arthritis-Interstitial Lung Disease

Kim,

Yang,

Kim

2023

IJMS

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Interstitial lung disease (ILD) is one of the most serious extra-articular complications of rheumatoid arthritis (RA), which increases the mortality of RA. Because the pathogenesis of RA-ILD remains poorly understood, appropriate therapeutic strategies and biomarkers have not yet been identified. Thus, the goal of this review was to summarize and analyze the reported data on the etiology and pathogenesis of RA-ILD. The incidence of RA-ILD increases with age, and is also generally higher in men than in women and in patients with specific genetic variations and ethnicity. Lifestyle factors associated with an increased risk of RA-ILD include smoking and exposure to pollutants. The presence of an anti-cyclic citrullinated peptide antibody, high RA disease activity, and rheumatoid factor positivity also increase the risk of RA-ILD. We also explored the roles of biological processes (e.g., fibroblast–myofibroblast transition, epithelial–mesenchymal transition, and immunological processes), signaling pathways (e.g., JAK/STAT and PI3K/Akt), and the histopathology of RA involved in RA-ILD pathogenesis based on published preclinical and clinical models of RA-ILD in animal and human studies.

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Section: Emtmentioning

confidence: 99%

Etiology and Pathogenesis of Rheumatoid Arthritis-Interstitial Lung Disease

Kim,

Yang,

Kim

2023

IJMS

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“…Biomarkers, such as serum ACPAS, MMP7, and CXCL10, and some heat shock proteins have been identified. In the KORAIL Cohort Baseline Data study, not only MMP7, but also SP-D and KL-6 were found to be useful for evaluating the functional and anatomical status of lung involvement in patients with RA-ILD [ 57 ]. However, these biomarkers are currently not used in clinical practice [ 58 , 59 ].…”

Section: Clinical Aspects Of Ra-ildmentioning

confidence: 99%

Recent Advances in Basic and Clinical Aspects of Rheumatoid Arthritis-associated Interstitial Lung Diseases

Lee

Kim

2022

J Rheum Dis

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Rheumatoid arthritis (RA) is a common autoimmune disease that mainly affects the joints and systemic organs, such as the skin, eyes, heart, gastrointestinal tract, and lungs. In particular, among various pulmonary involvements, interstitial lung disease (ILD) is closely related to the selection of anti-rheumatic drugs and the long-term prognosis of patients with RA. Although the exact pathogenesis of RA-ILD is not well defined, several mechanistic pathways, similar to those of idiopathic pulmonary fibrosis, have been elucidated recently. Conversely, RA-related autoantibodies, including anti-cyclic citrullinated peptide antibody, are detectable in circulation and in the lungs, even in the absence of articular symptoms. RA-ILD can also predate years before the occurrence of joint symptoms. This evidence supports the fact that local dysregulated mucosal immunity in the lung causes systemic autoimmunity, resulting in clinically evident polyarthritis of RA. Because the early diagnosis of RA-ILD is important, imaging tests, such as computed tomography and pulmonary function tests, are being used for early diagnosis, but there is no clear guideline for the early diagnosis of RA-ILD and selection of optimal disease-modifying anti-rheumatic drugs for the treatment of patients with RA with ILD. In addition, the efficacy of nintedanib, a new anti-fibrotic agent, for RA-ILD treatment, has been investigated recently. This review collectively discusses the basic and clinical aspects, such as pathogenesis, animal models, diagnosis, and treatment, of RA-ILD.

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“…The classification criteria for systemic sclerosis (SSc) include ILD [ 7 ]. Although classification criteria for SSc includes ILD as one item as classification criteria, however, other autoimmune diseases, such as rheumatoid arthritis (RA), inflammatory myositis, primary Sjögren’s syndrome (pSS), and systemic lupus erythematosus (SLE) can also present with ILD [ 3 , 8 ]. Nailfold capillaroscopy (NFC) can detect abnormalities in microcirculation, and abnormal findings of NFC are mainly found in patients with SSc [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Nailfold capillaroscopy findings of interstitial pneumonia with autoimmune features

Lee,

Min,

Kim

et al. 2023

Korean J Intern Med

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Background/Aims: We evaluated nailfold capillaroscopy (NFC) of interstitial pneumonia with autoimmune features (IPAF) and compared it with that of patients with connective tissue disease-interstitial lung disease (CTD-ILD) and idiopathic interstitial pneumonia (IIP).Methods: Patients with newly diagnosed as ILD were evaluated using NFC. Baseline demographic, clinical, serological, and high-resolution CT findings were collected. NFC was semi-quantitatively scored with six domains ranging from 0 to 18. In addition, the overall patterns (scleroderma/non-scleroderma patterns) were determined.Results: A total of 81 patients (31 with CTD-ILD, 18 with IPAF, and 32 with IIP) were included. The non-specific interstitial pneumonia pattern was the most common ILD pattern in the CTD-ILD and IPAF groups, whereas the usual interstitial pneumonia pattern was the most common in the IIP group. The semi-quantitative score of the CTD-ILD group was higher than that of the IPAF or IIP groups (5.8 vs 4.2 vs 3.0, p < 0.001, respectively). Giant capillaries and haemorrhages were more frequently present in the CTD-ILD and IPAF groups than in the IIP group. A scleroderma pattern was present in 27.8% of the IPAF group, whereas none of the IIP patients showed a scleroderma pattern.Conclusions: NFC findings may be useful in classifying patients with ILD into CTD-ILD/IPAF/IIP.

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Association of Serum Biomarkers With Pulmonary Involvement of Rheumatoid Arthritis Interstitial Lung Disease: From KORAIL Cohort Baseline Data

Cited by 10 publications

References 31 publications

Etiology and Pathogenesis of Rheumatoid Arthritis-Interstitial Lung Disease

Etiology and Pathogenesis of Rheumatoid Arthritis-Interstitial Lung Disease

Recent Advances in Basic and Clinical Aspects of Rheumatoid Arthritis-associated Interstitial Lung Diseases

Nailfold capillaroscopy findings of interstitial pneumonia with autoimmune features

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