Prognostic risk factors of early gastric cancer—a western experience

Haist, Thomas; Pritzer, H.; Pauthner, Michael; Fisseler‐Eckhoff, Annette; Lorenz, D.

doi:10.1007/s00423-016-1395-2

Cited by 8 publications

(12 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The degree of tumor differentiation is a predictive and prognosis biomarker for patients with gastric cancer [ 29 ], which can be distinguished quantitatively by dual-energy spectral CT (DESCT). Pan et al [ 12 ] evaluated the clinical usefulness of DESCT in the classification and staging of gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Detection of gastric cancer and its histological type based on iodine concentration in spectral CT

Wang

et al. 2018

Cancer Imaging

View full text Add to dashboard Cite

BackgroundComputed tomography (CT) imaging is the most common imaging modality for the diagnosis and staging of gastric cancer. The aim of this study is was to prospectively explore the ability of quantitative spectral CT parameters in the detection of gastric cancer and its histologic types.MethodsA total of 87 gastric adenocarcinoma (43 poorly and 44 well-differentiated) patients and 36 patients with benign gastric wall lesions (25 inflammation and 11 normal), who underwent dual-phase enhanced spectral CT examination, were retrospectively enrolled in this study. Iodine concentration (IC) and normalized iodine concentration (nIC) during arterial phase (AP) and portal venous phase (PP) were measured thrice in each patient by two blinded radiologists. Moreover, intraclass correlation coefficient (ICC) was used to assess the interobserver reproducibility. Differences of IC and nIC values between gastric cancer and benign lesion groups were compared using Mann-Whitney U test. Furthermore, the gender, age, location, thickness and histological types of gastric adenocarcinoma were analyzed by Mann-Whitney U test or Kruskal-Wallis H test. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic efficacy of IC and nIC values, and the optimal cut-off value was calculated with Youden J.ResultsAn excellent interobserver agreement (ICC > 0.6) was achieved for IC. Notably, the values of ICAP, ICPP, nICAP and nICPP were significantly higher in gastric cancer group (Z = 5.870, 3.894, 2.009 and 10.137, respectively; P < 0.05) than those in benign lesion group. Additionally, the values of ICAP, ICPP, nICAP and nICPP were significantly higher in poorly differentiated gastric adenocarcinoma group (Z = 4.118, 5.637, 6.729 and 2.950, respectively; P < 0.005) than those in well-differentiated gastric adenocarcinoma group. There were no statistically significant differences in the values of ICAP, ICPP, nICAP and nICPP between age, gender, tumor thickness and tumor location. Furthermore, the area under the curve (AUC) values of ICAP, nICAP, ICPP and nICPP were 0.745, 0.584, 0.662, and 0.932, respectively, for gastric cancer detection; while 0.756, 0.919, 0.851 and 0.684, respectively, in discriminating poorly differentiated gastric adenocarcinoma.ConclusionIC values exhibited great potential in the preoperative and non-invasive diagnosis of gastric cancer and its histological types. In particular, nICPP is more effective for the identification of gastric cancer, whereas nICAP is more effective in discriminating poorly differentiated gastric adenocarcinoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Detection of gastric cancer and its histological type based on iodine concentration in spectral CT

Wang

et al. 2018

Cancer Imaging

View full text Add to dashboard Cite

show abstract

“…et al [ 23 ] Brazil 2014 26 16.7% 42.9% Not available Fukuhara S. et al [ 10 ] USA 2014 104 7.1% 35.4% Lymphovascular invasion, non-Asian race and younger age. Haist T. et al [ 22 ] Germany 2016 124 1.9% 22.5% Depth of invasion, lymphovascular invasion. Ahmad R. et al [ 18 ] USA 2016 67 4.3% 31.8% Lymphovascular invasion and positive nodal status by endoscopic ultrasound.…”

Section: Discussionmentioning

confidence: 99%

“…Up to this date, evidence of a correlation between lymphatic invasion and worse survival results have been demonstrated only by studies performed in Asia, with Western studies confirming these findings. Haist et al analyzed lymphatic invasion and survival result correlation in a Western cohort, however they did not display a significant effect of lymphatic invasion on longtime survival results [ 22 ]. Consequently, our study became the first of such Western reports to present lymphovascular invasion as an independent prognostic factor associated with worse long-term survival results.…”

Section: Discussionmentioning

confidence: 99%

“…More than 15 lymph nodes were removed for 72% of the patients and only 9% of cases included less than ten dissected lymph nodes. Also, patients with insufficient lymphanodectomy were not excluded from our study to avoid discrepancies as we compared our study results to five other studies from Western countries, where patients with less than 15 examined lymph nodes were included [ 18 , 20 , 22 – 24 ]. Moreover if only patients with ≥15 resected LN would have been analyzed, the percentage of lymph node metastasis would not be much higher than in the whole series (T1a cancer - 5,1% vs 5,6%, T1b cancer 31,9% vs 36%).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Risk factors for lymph node metastasis in early gastric cancer patients: Report from Eastern Europe country– Lithuania

Baušys

Vysniauskaite

et al. 2017

BMC Surg

View full text Add to dashboard Cite

BackgroundCurrent risk factors for lymph node metastasis in early gastric cancer have been primarily determined in Asian countries; however their applicability to Western nations is under discussion. The aim of our study was to identify risk factors associated with lymph node metastasis in Western cohort patients from the Eastern European country - Lithuania.MethodsA total of 218 patients who underwent open gastrectomy for early gastric cancer were included in this retrospective study. After histolopathological examination, risk factors for lymph node metastasis were evaluated. Overall survival was evaluated and factors associated with long-term outcomes were analyzed.ResultsLymph node metastases were present in 19.7% of early gastric cancer cases. The rates were 5/99 (4.95%) for pT1a tumors and 38/119 (31.9%) for pT1b tumors. Submucosal tumor invasion, lymphovascular invasion, and high grade tumor differentiation were identified as independent risk factors for lymph node metastasis. Submucosal tumor invasion and lymphovascular invasion were also associated with worse 5-year survival results.ConclusionOur study established submucosal tumor invasion, lymphovascular invasion, and high grade tumor differentiation as risk factors for lymph node metastasis.

show abstract

“…Contrary to the above findings, most of the reports, including a large meta-analysis by Petrelli et al involving 50 studies and 128,268 patients with gastric cancer, showed that a location in the upper third part of the stomach was connected with an increased risk of tumor-related death and poorer 5-year survival rate (15,33,(38)(39)(40).…”

Section: Discussionmentioning

confidence: 71%

Clinicopathological Prognostic Factors Determining Outcomes of Treatment in Gastric Cancer Surgery

Kulig

Pach

Majewska

et al. 2022

In Vivo

View full text Add to dashboard Cite

Background/Aim: The purpose of this study was to examine the impact of clinicopathological prognostic factors on tumor resectability, perioperative complications, and 5year survival rates in patients with gastric cancer treated surgically. Patients and Methods: A cohort of 834 patients operated on for gastric cancer between 2007 and 2016 was analyzed. Results: Patients over 70 years of age manifested a significantly higher rate of overall complications, systemic complications, surgical complications, perioperative mortality, and a worse 5-year survival. The diffuse type according to the Lauren classification was an independent prognostic factor for perioperative mortality. TNM stage significantly influenced resectability and 5-year survival rates. Furthermore, the presence of distant metastases (M1 stage) significantly increased the rates of overall complications, systemic complications, and perioperative mortality. Conclusion: Although TNM stage was the most important prognostic factor for resectability, perioperative complications and 5-year survival, other clinicopathological prognostic factors, such as age, and Lauren type also significantly affected treatment outcomes in gastric cancer surgery.

show abstract

Prognostic risk factors of early gastric cancer—a western experience

Cited by 8 publications

References 38 publications

Detection of gastric cancer and its histological type based on iodine concentration in spectral CT

Detection of gastric cancer and its histological type based on iodine concentration in spectral CT

Risk factors for lymph node metastasis in early gastric cancer patients: Report from Eastern Europe country– Lithuania

Clinicopathological Prognostic Factors Determining Outcomes of Treatment in Gastric Cancer Surgery

Contact Info

Product

Resources

About