Risk factors for lymph node metastasis in early gastric cancer patients: Report from Eastern Europe country– Lithuania

Baušys, Rimantas; Baušys, Augustinas; Vysniauskaite, Indre; Maneikis, Kazimieras; Klimas, D.; Lukšta, Martynas; Strupas, Kęstutis; Stratilatovas, Eugenijus

doi:10.1186/s12893-017-0304-0

Cited by 27 publications

(28 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The location of tumor was categorized as cardia, corpus/fundus, and antrum/angularis/pylorus. Tumor size which means the maximum diameter of tumor was recorded with continuous variable, then converted to a classification variable with the threshold value < 2.20 cm and ≥ 2.20 cm, analyzed by optimal binning, which was consistent with previous studies [14,16]. The macroscopic feature was classified into three groups: elevated type (types I and IIa), flat type (type IIb), or depressed type (types IIc and III).…”

Section: Clinicopathologic Characteristicsmentioning

confidence: 91%

“…But the probability of LNM is still evaluated by the general guidelines and surgeon's experience without quantified standards in clinical practice nowadays. Although several studies have tried to explore the risk factors of LNM in EGC, most items involved, such as lymphovascular invasion and depth of tumor invasion, were unavailable preoperatively [13,14]. The comprehensive analysis of gastroscopic findings, tumor markers, and radiology images, rather than individual analyses, is the most promising way to improve clinical management [15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development and validation of a nomogram for preoperative prediction of lymph node metastasis in early gastric cancer

et al. 2020

View full text Add to dashboard Cite

Background: The status of lymph nodes in early gastric cancer is critical to make further clinical treatment decision, but the prediction of lymph node metastasis remains difficult before operation. This study aimed to develop a nomogram that contained preoperative factors to predict lymph node metastasis in early gastric cancer patients. Methods: This study analyzed the clinicopathologic features of 823 early gastric cancer patients who underwent gastrectomy retrospectively, among which 596 patients were recruited in the training cohort and 227 patients in the independent validation cohort. Significant risk factors in univariate analysis were further identified to be independent variables in multivariable logistic regression analysis, which were then incorporated in and presented with a nomogram. And internal and external validation curves were plotted to evaluate the discrimination of the nomogram. Results: Totally, six independent predictors, including the tumor size, macroscopic features, histology differentiation, P53, carbohydrate antigen 19-9, and computed tomography-reported lymph node status, were enrolled in the nomogram. Both the internal validation in the training cohort and the external validation in the validation cohort showed the nomogram had good discriminations, with a C-index of 0.82 (95%CI, 0.78 to 0.86) and 0.77 (95%CI, 0.60 to 0.94) respectively. Conclusions: Our study developed a new nomogram which contained the most common and significant preoperative risk factors for lymph node metastasis in patients with early gastric cancer. The nomogram can identify early gastric cancer patients with the high probability of lymph node metastasis and help clinicians make more appropriate decisions in clinical practice.

show abstract

Section: Clinicopathologic Characteristicsmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Development and validation of a nomogram for preoperative prediction of lymph node metastasis in early gastric cancer

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Shen L et al [18] reported that LNM was observed in 12.20% of EGC patients. In another study [22], LNM was reported in 19.7% of EGC cases. The reported rates range from 5.7-20% of patients [23][24][25][26][27][28].…”

Section: Discussionmentioning

confidence: 85%

The predictive prognostic factors and risk factors of lymph node metastasis in patients with early gastric cancer

Zu¹,

Wang²,

Ma³

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Determining the prognosis of early gastric cancer (EGC) is very important for the selection of preoperative treatment strategies. The purpose of this paper was to investigate the clinicopathological features and prognostic factors in EGC and the related risk factors of lymph node metastasis (LNM). Methods: From March 2007 through December 2010, 1004 patients who underwent gastrectomy at Harbin Medical University were retrospectively identified; 120 patients were diagnosed with EGC. The clinicopathological features and prognostic factors were analysed by univariate and multivariate analyses. Multivariate logistic regression analysis was used to discern risk factors for LNM in EGC. Results: The incidence of EGC was 11.96%. A univariate analysis showed that age, preoperative haemoglobin (Hb) level, prealbumin level, tumour size and LNM were significant prognostic factors. A multivariate analysis showed that the preoperative Hb level and LNM were independent prognostic factors. A multivariate logistic regression analysis revealed that age, Ca-199 level and macroscopic tumour type were independent risk factors for LNM in EGC. Conclusions: Preoperative Hb level and LNM were both independent prognostic factors for EGC. These factors may help surgeons implement appropriate treatment strategies during the perioperative period.

show abstract

“…However, good outcomes in the follow-up group according to DSS and recurrence rates should be treated carefully due to different background characteristics of the study groups. Some major risk factors for LNM (lymphatic invasion or deeper submucosal invasion) were significantly more frequent in the additional radical surgery group [ 18 , 19 ], and these differences may influence the study results. Furthermore, Suzuki et al [ 20 ] recently published results from the similar study and showed a clear superiority of additional surgery after non-curative ESD compared to follow-up.…”

Section: Discussionmentioning

confidence: 99%

Safety of expanded criteria for endoscopic resection of early gastric cancer in a Western cohort

Baušys

Maneikis

et al. 2018

BMC Surg

Self Cite

View full text Add to dashboard Cite

BackgroundEndoscopic resection is widely accepted treatment option for early gastric cancer if tumors meet the standard or expanded indications. However, the safety of expanded criteria is still under investigation. Furthermore, discussion, if any additional treatment is necessary for patients who underwent endoscopic resection but exceeded expanded criteria, is rising. This study aimed to evaluate the safety of extended indications for endoscopic resection of early gastric cancer in a Western cohort. Also, we aimed to analyze the lymph node metastasis rate in tumors which exceeds the extended criteria.MethodsTwo hundred eighteen patients who underwent surgery for early gastric cancer at National Cancer Institute, Vilnius, Lithuania between 2005 and 2015 were identified from a prospective database. Lymph node status was examined in 197 patients who met or exceeded extended indications for endoscopic resection.ResultsLymph node metastasis was detected in 1.7% of cancers who met extended indications and in 30.2% of cancers who exceeded expanded indications. Lymphovascular invasion and deeper tumor invasion is associated with lymph node metastasis in cancers exceeding expanded indications.ConclusionsExpanded criteria for endoscopic resection of early gastric cancer in Western settings is not entirely safe because these tumors carry the risk of lymph node metastasis.

show abstract

Risk factors for lymph node metastasis in early gastric cancer patients: Report from Eastern Europe country– Lithuania

Cited by 27 publications

References 31 publications

Development and validation of a nomogram for preoperative prediction of lymph node metastasis in early gastric cancer

Development and validation of a nomogram for preoperative prediction of lymph node metastasis in early gastric cancer

The predictive prognostic factors and risk factors of lymph node metastasis in patients with early gastric cancer

Safety of expanded criteria for endoscopic resection of early gastric cancer in a Western cohort

Contact Info

Product

Resources

About